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Photoreceptor cells and RPE contribute to the development of diabetic retinopathy.
Prog Retin Eye Res. 2021 07; 83:100919.PR

Abstract

Diabetic retinopathy (DR) is a leading cause of blindness. It has long been regarded as vascular disease, but work in the past years has shown abnormalities also in the neural retina. Unfortunately, research on the vascular and neural abnormalities have remained largely separate, instead of being integrated into a comprehensive view of DR that includes both the neural and vascular components. Recent evidence suggests that the most predominant neural cell in the retina (photoreceptors) and the adjacent retinal pigment epithelium (RPE) play an important role in the development of vascular lesions characteristic of DR. This review summarizes evidence that the outer retina is altered in diabetes, and that photoreceptors and RPE contribute to retinal vascular alterations in the early stages of the retinopathy. The possible molecular mechanisms by which cells of the outer retina might contribute to retinal vascular damage in diabetes also are discussed. Diabetes-induced alterations in the outer retina represent a novel therapeutic target to inhibit DR.

Authors+Show Affiliations

Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA.Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA; Veterans Administration Medical Center Research Service, Cleveland, OH, USA; Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA, USA; Veterans Administration Medical Center Research Service, Long Beach, CA, USA. Electronic address: kernt@uci.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

33188897

Citation

Tonade, Deoye, and Timothy S. Kern. "Photoreceptor Cells and RPE Contribute to the Development of Diabetic Retinopathy." Progress in Retinal and Eye Research, vol. 83, 2021, p. 100919.
Tonade D, Kern TS. Photoreceptor cells and RPE contribute to the development of diabetic retinopathy. Prog Retin Eye Res. 2021;83:100919.
Tonade, D., & Kern, T. S. (2021). Photoreceptor cells and RPE contribute to the development of diabetic retinopathy. Progress in Retinal and Eye Research, 83, 100919. https://doi.org/10.1016/j.preteyeres.2020.100919
Tonade D, Kern TS. Photoreceptor Cells and RPE Contribute to the Development of Diabetic Retinopathy. Prog Retin Eye Res. 2021;83:100919. PubMed PMID: 33188897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Photoreceptor cells and RPE contribute to the development of diabetic retinopathy. AU - Tonade,Deoye, AU - Kern,Timothy S, Y1 - 2020/11/12/ PY - 2020/08/08/received PY - 2020/10/27/revised PY - 2020/10/31/accepted PY - 2022/07/01/pmc-release PY - 2020/11/15/pubmed PY - 2020/11/15/medline PY - 2020/11/14/entrez KW - Diabetes KW - Diabetic retinopathy KW - Outer retina KW - Photoreceptors KW - Phototransduction KW - RPE KW - Vasculature KW - Visual cycle SP - 100919 EP - 100919 JF - Progress in retinal and eye research JO - Prog Retin Eye Res VL - 83 N2 - Diabetic retinopathy (DR) is a leading cause of blindness. It has long been regarded as vascular disease, but work in the past years has shown abnormalities also in the neural retina. Unfortunately, research on the vascular and neural abnormalities have remained largely separate, instead of being integrated into a comprehensive view of DR that includes both the neural and vascular components. Recent evidence suggests that the most predominant neural cell in the retina (photoreceptors) and the adjacent retinal pigment epithelium (RPE) play an important role in the development of vascular lesions characteristic of DR. This review summarizes evidence that the outer retina is altered in diabetes, and that photoreceptors and RPE contribute to retinal vascular alterations in the early stages of the retinopathy. The possible molecular mechanisms by which cells of the outer retina might contribute to retinal vascular damage in diabetes also are discussed. Diabetes-induced alterations in the outer retina represent a novel therapeutic target to inhibit DR. SN - 1873-1635 UR - https://www.unboundmedicine.com/medline/citation/33188897/Photoreceptor_cells_and_RPE_contribute_to_the_development_of_diabetic_retinopathy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1350-9462(20)30091-4 DB - PRIME DP - Unbound Medicine ER -