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Preparation and characterization of nanostarch-based green hard capsules reinforced by cellulose nanocrystals.
Int J Biol Macromol. 2021 Jan 15; 167:1241-1247.IJ

Abstract

The green hard capsules were prepared with corn nano-starch (CNS) and cellulose nanocrystal (CNC) in this study, the glycerol and carrageenan were used as plasticizer and gelling agent in the CNS/CNC gel solution, respectively. The capsule-films with different CNC content were prepared by casting method, and the dipping method was used in preparation of the corresponding capsules. The compatibility of CNS/CNC capsules was analyzed by Fourier Transform Infrared spectroscopy (FTIR) and X-Ray Diffraction (XRD), and the morphology of the capsules was analyzed by Scanning Electron Microscopy (SEM). The results showed that the tensile strength of the CNS based capsule-film was significantly improved with the addition of CNC. When the content of CNC was 6.0%, the tensile strength increased by 238.10%. The transparency of the capsule with different CNC contents was slightly reduced, but was greater than 87.0%. The loss on drying of CNS/CNC capsule was between 12.87% and 15.03%, and it could be completely dissolved in the artificial gastric juice within 6.0 min, which was in accordance with the provisions of Chinese Pharmacopoeia (2015).

Authors+Show Affiliations

Hunan Provincial Engineering Research Center for Food Processing of Aquatic Biotic Resources, School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, Hunan Province 410114, People's Republic of China. Electronic address: chenqijie@csust.edu.cn.Hunan Provincial Engineering Research Center for Food Processing of Aquatic Biotic Resources, School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, Hunan Province 410114, People's Republic of China.Hunan Provincial Engineering Research Center for Food Processing of Aquatic Biotic Resources, School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, Hunan Province 410114, People's Republic of China.Hunan Provincial Engineering Research Center for Food Processing of Aquatic Biotic Resources, School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, Hunan Province 410114, People's Republic of China.Hunan Provincial Engineering Research Center for Food Processing of Aquatic Biotic Resources, School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, Hunan Province 410114, People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33189752

Citation

Chen, QiJie, et al. "Preparation and Characterization of Nanostarch-based Green Hard Capsules Reinforced By Cellulose Nanocrystals." International Journal of Biological Macromolecules, vol. 167, 2021, pp. 1241-1247.
Chen Q, Zong Z, Gao X, et al. Preparation and characterization of nanostarch-based green hard capsules reinforced by cellulose nanocrystals. Int J Biol Macromol. 2021;167:1241-1247.
Chen, Q., Zong, Z., Gao, X., Zhao, Y., & Wang, J. (2021). Preparation and characterization of nanostarch-based green hard capsules reinforced by cellulose nanocrystals. International Journal of Biological Macromolecules, 167, 1241-1247. https://doi.org/10.1016/j.ijbiomac.2020.11.078
Chen Q, et al. Preparation and Characterization of Nanostarch-based Green Hard Capsules Reinforced By Cellulose Nanocrystals. Int J Biol Macromol. 2021 Jan 15;167:1241-1247. PubMed PMID: 33189752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and characterization of nanostarch-based green hard capsules reinforced by cellulose nanocrystals. AU - Chen,QiJie, AU - Zong,ZhangYang, AU - Gao,Xin, AU - Zhao,YaLan, AU - Wang,JianHui, Y1 - 2020/11/13/ PY - 2020/09/05/received PY - 2020/11/02/revised PY - 2020/11/11/accepted PY - 2020/11/16/pubmed PY - 2021/5/1/medline PY - 2020/11/15/entrez KW - Cellulose nanocrystals KW - Corn nano-starch KW - Disintegration time KW - Hard capsule SP - 1241 EP - 1247 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 167 N2 - The green hard capsules were prepared with corn nano-starch (CNS) and cellulose nanocrystal (CNC) in this study, the glycerol and carrageenan were used as plasticizer and gelling agent in the CNS/CNC gel solution, respectively. The capsule-films with different CNC content were prepared by casting method, and the dipping method was used in preparation of the corresponding capsules. The compatibility of CNS/CNC capsules was analyzed by Fourier Transform Infrared spectroscopy (FTIR) and X-Ray Diffraction (XRD), and the morphology of the capsules was analyzed by Scanning Electron Microscopy (SEM). The results showed that the tensile strength of the CNS based capsule-film was significantly improved with the addition of CNC. When the content of CNC was 6.0%, the tensile strength increased by 238.10%. The transparency of the capsule with different CNC contents was slightly reduced, but was greater than 87.0%. The loss on drying of CNS/CNC capsule was between 12.87% and 15.03%, and it could be completely dissolved in the artificial gastric juice within 6.0 min, which was in accordance with the provisions of Chinese Pharmacopoeia (2015). SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/33189752/Preparation_and_characterization_of_nanostarch_based_green_hard_capsules_reinforced_by_cellulose_nanocrystals_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(20)35001-7 DB - PRIME DP - Unbound Medicine ER -