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Antitumor and metastasis-inhibitory activities of lentinan as an immunomodulator: an overview.
Cancer Detect Prev Suppl. 1987; 1:423-43.CD

Abstract

The antitumor and metastasis-inhibitory activities, mode of action, and clinical application of lentinan, a strictly purified beta-1,6:beta-1,3-glucan, are reviewed. Lentinan exerts a prominent antitumor effect and prevents chemical and viral oncogenesis. The antitumor action of lentinan is host-mediated. Compared to other well-known immunostimulants, such as bacille Calmette Guérin (BCG), Corynebacterium parvum, and lipopolysaccharide (LPS), lentinan appears to represent a unique class of immunopotentiator, a T cell-oriented adjuvant. Lentinan triggers the increased production of various kinds of bioactive serum factors associated with immunity and inflammation, such as IL-1, CSF, IL-3, vascular dilation inducer, and acute-phase protein inducer, by the direct impact of macrophages or indirectly via lentinan-stimulated T cells, which results in the induction of many immunobiological changes in the host. Augmented IL-1 production amplifies the maturation of immature effector cells to mature cells capable of responding to lymphokines such as IL-2 and T cell-replacing factors. Because of this mode of action, intact T cell compartments for antitumor activity of lentinan are required. Lentinan has little toxic side effects. Excellent results were obtained in a 4 year follow-up of the randomized control study of lentinan in phase III on patients with advanced and recurrent stomach and colorectal cancer.

Authors+Show Affiliations

Chihara G
National Cancer Center Research Institute, Tokyo, Japan.
Hamuro J
No affiliation info available
Maeda YY
No affiliation info available
Shiio T
No affiliation info available
Suga T
No affiliation info available
Takasuka N
No affiliation info available
Sasaki T
No affiliation info available

MeSH

Adjuvants, ImmunologicAnimalsAntineoplastic AgentsImmunotherapyLentinanNeoplasm MetastasisNeoplasms, ExperimentalPolysaccharides

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

3319150

Citation

Chihara, G, et al. "Antitumor and Metastasis-inhibitory Activities of Lentinan as an Immunomodulator: an Overview." Cancer Detection and Prevention. Supplement : Official Publication of the International Society for Preventive Oncology, Inc, vol. 1, 1987, pp. 423-43.
Chihara G, Hamuro J, Maeda YY, et al. Antitumor and metastasis-inhibitory activities of lentinan as an immunomodulator: an overview. Cancer Detect Prev Suppl. 1987;1:423-43.
Chihara, G., Hamuro, J., Maeda, Y. Y., Shiio, T., Suga, T., Takasuka, N., & Sasaki, T. (1987). Antitumor and metastasis-inhibitory activities of lentinan as an immunomodulator: an overview. Cancer Detection and Prevention. Supplement : Official Publication of the International Society for Preventive Oncology, Inc, 1, 423-43.
Chihara G, et al. Antitumor and Metastasis-inhibitory Activities of Lentinan as an Immunomodulator: an Overview. Cancer Detect Prev Suppl. 1987;1:423-43. PubMed PMID: 3319150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antitumor and metastasis-inhibitory activities of lentinan as an immunomodulator: an overview. AU - Chihara,G, AU - Hamuro,J, AU - Maeda,Y Y, AU - Shiio,T, AU - Suga,T, AU - Takasuka,N, AU - Sasaki,T, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 423 EP - 43 JF - Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc JO - Cancer Detect Prev Suppl VL - 1 N2 - The antitumor and metastasis-inhibitory activities, mode of action, and clinical application of lentinan, a strictly purified beta-1,6:beta-1,3-glucan, are reviewed. Lentinan exerts a prominent antitumor effect and prevents chemical and viral oncogenesis. The antitumor action of lentinan is host-mediated. Compared to other well-known immunostimulants, such as bacille Calmette Guérin (BCG), Corynebacterium parvum, and lipopolysaccharide (LPS), lentinan appears to represent a unique class of immunopotentiator, a T cell-oriented adjuvant. Lentinan triggers the increased production of various kinds of bioactive serum factors associated with immunity and inflammation, such as IL-1, CSF, IL-3, vascular dilation inducer, and acute-phase protein inducer, by the direct impact of macrophages or indirectly via lentinan-stimulated T cells, which results in the induction of many immunobiological changes in the host. Augmented IL-1 production amplifies the maturation of immature effector cells to mature cells capable of responding to lymphokines such as IL-2 and T cell-replacing factors. Because of this mode of action, intact T cell compartments for antitumor activity of lentinan are required. Lentinan has little toxic side effects. Excellent results were obtained in a 4 year follow-up of the randomized control study of lentinan in phase III on patients with advanced and recurrent stomach and colorectal cancer. SN - 1043-6995 UR - https://www.unboundmedicine.com/medline/citation/3319150/Antitumor_and_metastasis_inhibitory_activities_of_lentinan_as_an_immunomodulator:_an_overview_ DB - PRIME DP - Unbound Medicine ER -