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Risk of yellow fever virus transmission in the Asia-Pacific region.
Nat Commun. 2020 11 16; 11(1):5801.NC

Abstract

Historically endemic to Sub-Saharan Africa and South America, yellow fever is absent from the Asia-Pacific region. Yellow fever virus (YFV) is mainly transmitted by the anthropophilic Aedes mosquitoes whose distribution encompasses a large belt of tropical and sub tropical regions. Increasing exchanges between Africa and Asia have caused imported YFV incidents in non-endemic areas, which are threatening Asia with a new viral emergence. Here, using experimental infections of field-collected mosquitoes, we show that Asian-Pacific Aedes mosquitoes are competent vectors for YFV. We observe that Aedes aegypti populations from Singapore, Taiwan, Thailand, and New Caledonia are capable of transmitting YFV 14 days after oral infections, with a number of viral particles excreted from saliva reaching up to 23,000 viral particles. These findings represent the most comprehensive assessment of vector competence and show that Ae. aegypti mosquitoes from the Asia-Pacific region are highly competent to YFV, corroborating that vector populations are seemingly not a brake to the emergence of yellow fever in the region.

Authors+Show Affiliations

Arboviruses and Insect Vectors Unit, Institut Pasteur, Paris, France.Arboviruses and Insect Vectors Unit, Institut Pasteur, Paris, France.Bioinformatics and Biostatistics Hub, Institut Pasteur, USR 3756, CNRS, Paris, France. Malaria Unit: Parasites and Hosts, Institut Pasteur, Paris, France.Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France.Arboviruses and Insect Vectors Unit, Institut Pasteur, Paris, France.Department of Medical Entomology, Centre for Research in Infectious Diseases, Yaoundé, Cameroon.National Health Research Institutes, Institute of Infectious Diseases and Vaccinology, Miaoli, Taiwan.Arboviruses and Insect Vectors Unit, Institut Pasteur, Paris, France. anna-bella.failloux@pasteur.fr.Arboviruses and Insect Vectors Unit, Institut Pasteur, Paris, France. pei-shi.yen@pasteur.fr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33199712

Citation

Lataillade, Lucy de Guilhem de, et al. "Risk of Yellow Fever Virus Transmission in the Asia-Pacific Region." Nature Communications, vol. 11, no. 1, 2020, p. 5801.
Lataillade LG, Vazeille M, Obadia T, et al. Risk of yellow fever virus transmission in the Asia-Pacific region. Nat Commun. 2020;11(1):5801.
Lataillade, L. G., Vazeille, M., Obadia, T., Madec, Y., Mousson, L., Kamgang, B., Chen, C. H., Failloux, A. B., & Yen, P. S. (2020). Risk of yellow fever virus transmission in the Asia-Pacific region. Nature Communications, 11(1), 5801. https://doi.org/10.1038/s41467-020-19625-9
Lataillade LG, et al. Risk of Yellow Fever Virus Transmission in the Asia-Pacific Region. Nat Commun. 2020 11 16;11(1):5801. PubMed PMID: 33199712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of yellow fever virus transmission in the Asia-Pacific region. AU - Lataillade,Lucy de Guilhem de, AU - Vazeille,Marie, AU - Obadia,Thomas, AU - Madec,Yoann, AU - Mousson,Laurence, AU - Kamgang,Basile, AU - Chen,Chun-Hong, AU - Failloux,Anna-Bella, AU - Yen,Pei-Shi, Y1 - 2020/11/16/ PY - 2020/06/24/received PY - 2020/10/22/accepted PY - 2020/11/17/entrez PY - 2020/11/18/pubmed PY - 2020/11/26/medline SP - 5801 EP - 5801 JF - Nature communications JO - Nat Commun VL - 11 IS - 1 N2 - Historically endemic to Sub-Saharan Africa and South America, yellow fever is absent from the Asia-Pacific region. Yellow fever virus (YFV) is mainly transmitted by the anthropophilic Aedes mosquitoes whose distribution encompasses a large belt of tropical and sub tropical regions. Increasing exchanges between Africa and Asia have caused imported YFV incidents in non-endemic areas, which are threatening Asia with a new viral emergence. Here, using experimental infections of field-collected mosquitoes, we show that Asian-Pacific Aedes mosquitoes are competent vectors for YFV. We observe that Aedes aegypti populations from Singapore, Taiwan, Thailand, and New Caledonia are capable of transmitting YFV 14 days after oral infections, with a number of viral particles excreted from saliva reaching up to 23,000 viral particles. These findings represent the most comprehensive assessment of vector competence and show that Ae. aegypti mosquitoes from the Asia-Pacific region are highly competent to YFV, corroborating that vector populations are seemingly not a brake to the emergence of yellow fever in the region. SN - 2041-1723 UR - https://www.unboundmedicine.com/medline/citation/33199712/Risk_of_yellow_fever_virus_transmission_in_the_Asia_Pacific_region_ L2 - https://doi.org/10.1038/s41467-020-19625-9 DB - PRIME DP - Unbound Medicine ER -