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Subjective Effects of Alcohol Predict Alcohol Choice in Social Drinkers.
Alcohol Clin Exp Res. 2020 12; 44(12):2579-2587.AC

Abstract

INTRODUCTION

Alcohol is among the most commonly used psychoactive drugs, yet it can produce markedly different subjective effects in different people. Certain effects, including both heightened stimulatory effects and lesser sedative effects, are thought to predict repeated or excessive use. However, we do not fully understand the nature of these individual differences or their relationships to alcohol consumption. This controlled laboratory study examined subjective and physiologic responses to a moderate dose of alcohol in social drinkers in relation to the subjects' decision to consume alcohol.

METHODS

Healthy adult volunteers (N = 95) participated in a 5-session double-blind alcohol choice study. On the first 4 sessions, they received alcohol (0.8 g/kg) and placebo in alternating order, and on the fifth session, they chose and consumed whichever of the 2 they preferred. During each session, participants completed the Profile of Mood States (POMS) and Biphasic Alcohol Effects Scale (BAES) questionnaires and had their vitals recorded every 30 minutes. We compared subjective and physiologic response to alcohol during the sampling sessions in participants who chose alcohol or placebo on session 5.

RESULTS

Of the 95 participants, 55 chose alcohol (choosers) and 40 chose placebo (nonchoosers). In the full sample, alcohol produced its expected effects (e.g., increased friendliness, elation, and vigor (POMS), and stimulation and sedation (BAES)). The chooser and nonchooser groups did not differ in demographic characteristics, blood alcohol levels, or cardiovascular measures. However, the choosers experienced greater alcohol-induced increases in positive mood (POMS) and liked the drug more, whereas the nonchoosers experienced greater anger, anxiety (POMS), and sedation (BAES) after alcohol.

CONCLUSION

Both greater positive mood effects and lesser sedative effects after alcohol predicted preference under controlled conditions, suggesting that both factors can predict future consumption of alcohol.

Authors+Show Affiliations

From the, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.From the, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.From the, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.From the, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

33201577

Citation

Li, Jingfei, et al. "Subjective Effects of Alcohol Predict Alcohol Choice in Social Drinkers." Alcoholism, Clinical and Experimental Research, vol. 44, no. 12, 2020, pp. 2579-2587.
Li J, Murray CH, Weafer J, et al. Subjective Effects of Alcohol Predict Alcohol Choice in Social Drinkers. Alcohol Clin Exp Res. 2020;44(12):2579-2587.
Li, J., Murray, C. H., Weafer, J., & de Wit, H. (2020). Subjective Effects of Alcohol Predict Alcohol Choice in Social Drinkers. Alcoholism, Clinical and Experimental Research, 44(12), 2579-2587. https://doi.org/10.1111/acer.14476
Li J, et al. Subjective Effects of Alcohol Predict Alcohol Choice in Social Drinkers. Alcohol Clin Exp Res. 2020;44(12):2579-2587. PubMed PMID: 33201577.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subjective Effects of Alcohol Predict Alcohol Choice in Social Drinkers. AU - Li,Jingfei, AU - Murray,Conor H, AU - Weafer,Jessica, AU - de Wit,Harriet, Y1 - 2020/11/17/ PY - 2020/07/06/received PY - 2020/09/28/revised PY - 2020/09/29/accepted PY - 2020/11/18/pubmed PY - 2021/9/30/medline PY - 2020/11/17/entrez KW - Alcohol KW - Drug Choice KW - Mood KW - Social Drinkers KW - Subjective Effects SP - 2579 EP - 2587 JF - Alcoholism, clinical and experimental research JO - Alcohol Clin Exp Res VL - 44 IS - 12 N2 - INTRODUCTION: Alcohol is among the most commonly used psychoactive drugs, yet it can produce markedly different subjective effects in different people. Certain effects, including both heightened stimulatory effects and lesser sedative effects, are thought to predict repeated or excessive use. However, we do not fully understand the nature of these individual differences or their relationships to alcohol consumption. This controlled laboratory study examined subjective and physiologic responses to a moderate dose of alcohol in social drinkers in relation to the subjects' decision to consume alcohol. METHODS: Healthy adult volunteers (N = 95) participated in a 5-session double-blind alcohol choice study. On the first 4 sessions, they received alcohol (0.8 g/kg) and placebo in alternating order, and on the fifth session, they chose and consumed whichever of the 2 they preferred. During each session, participants completed the Profile of Mood States (POMS) and Biphasic Alcohol Effects Scale (BAES) questionnaires and had their vitals recorded every 30 minutes. We compared subjective and physiologic response to alcohol during the sampling sessions in participants who chose alcohol or placebo on session 5. RESULTS: Of the 95 participants, 55 chose alcohol (choosers) and 40 chose placebo (nonchoosers). In the full sample, alcohol produced its expected effects (e.g., increased friendliness, elation, and vigor (POMS), and stimulation and sedation (BAES)). The chooser and nonchooser groups did not differ in demographic characteristics, blood alcohol levels, or cardiovascular measures. However, the choosers experienced greater alcohol-induced increases in positive mood (POMS) and liked the drug more, whereas the nonchoosers experienced greater anger, anxiety (POMS), and sedation (BAES) after alcohol. CONCLUSION: Both greater positive mood effects and lesser sedative effects after alcohol predicted preference under controlled conditions, suggesting that both factors can predict future consumption of alcohol. SN - 1530-0277 UR - https://www.unboundmedicine.com/medline/citation/33201577/Subjective_Effects_of_Alcohol_Predict_Alcohol_Choice_in_Social_Drinkers_ L2 - https://doi.org/10.1111/acer.14476 DB - PRIME DP - Unbound Medicine ER -