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Factors Associated with a Positive Severe Acute Respiratory Syndrome Coronavirus 2 Testing in Suspected Cases Presenting with Pneumonia: A Retrospective Cohort Study in a Single Medical Center.
Respiration. 2020; 99(9):739-747.R

Abstract

BACKGROUND

Coronavirus disease 2019 (COVID-19) has become a global emerging infectious disease.

OBJECTIVES

To analyze the initial clinical characteristics of COVID-19 suspected and confirmed patients on admission in order to find out which kinds may be more likely to get positive nucleic acid testing results, and to explore the risk factors associated with all-cause death.

METHODS

Medical records from 309 highly suspected cases with pneumonia were collected from February 13, 2020, to March 14, 2020, in a COVID-19-designated hospital of Wuhan. The majority of the clinical data were collected on the first day of hospital admission.

RESULTS

Of 309 patients with median age 64 years (interquartile ranges [IQR], 53-72 years), 111 patients (35.9%) were confirmed by nucleic acid testing (median age 64 years, IQR: 56-71 years; 48 males). Of those 111 patients, 13 (11.7%) patients died. In multivariate analysis, factors associated with positive testing included fatigue (odds ratios [OR] = 3.14; 95% confidence interval [CI]: 1.88-5.24, p < 0.001), cough (OR = 0.55; 95% CI: 0.32-0.95, p = 0.032), no less than 1 comorbidity (OR = 1.77; 95% CI: 1.06-2.98, p = 0.030), and severe pneumonia (OR = 2.67; 95% CI: 1.20-5.97, p = 0.016). Furthermore, age, dyspnea, noneffective antibiotic treatment, white blood cell, lymphocyte, platelets, and organ dysfunction (e.g., higher lactate dehydrogenase) were significantly associated with all-cause in-hospital death in patients with COVID-19.

CONCLUSION

Patients with severe forms of this disease were more likely to get positive results. Age and organ dysfunction were associated with a greater risk of death.

Authors+Show Affiliations

Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.Department of Respiration, Harbin City First Hospital, Harbin, China.Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.Department of Cadre's Ward, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.Department of Nephrology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China, chenhong744563@aliyun.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33207356

Citation

Li, Yupeng, et al. "Factors Associated With a Positive Severe Acute Respiratory Syndrome Coronavirus 2 Testing in Suspected Cases Presenting With Pneumonia: a Retrospective Cohort Study in a Single Medical Center." Respiration; International Review of Thoracic Diseases, vol. 99, no. 9, 2020, pp. 739-747.
Li Y, Shang Y, Yang Y, et al. Factors Associated with a Positive Severe Acute Respiratory Syndrome Coronavirus 2 Testing in Suspected Cases Presenting with Pneumonia: A Retrospective Cohort Study in a Single Medical Center. Respiration. 2020;99(9):739-747.
Li, Y., Shang, Y., Yang, Y., Wang, M., Yu, D., Su, D., Liu, L., Wang, Q., Zhang, X., Ren, J., & Chen, H. (2020). Factors Associated with a Positive Severe Acute Respiratory Syndrome Coronavirus 2 Testing in Suspected Cases Presenting with Pneumonia: A Retrospective Cohort Study in a Single Medical Center. Respiration; International Review of Thoracic Diseases, 99(9), 739-747. https://doi.org/10.1159/000508398
Li Y, et al. Factors Associated With a Positive Severe Acute Respiratory Syndrome Coronavirus 2 Testing in Suspected Cases Presenting With Pneumonia: a Retrospective Cohort Study in a Single Medical Center. Respiration. 2020;99(9):739-747. PubMed PMID: 33207356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors Associated with a Positive Severe Acute Respiratory Syndrome Coronavirus 2 Testing in Suspected Cases Presenting with Pneumonia: A Retrospective Cohort Study in a Single Medical Center. AU - Li,Yupeng, AU - Shang,Yu, AU - Yang,Yi, AU - Wang,Menghan, AU - Yu,Dongping, AU - Su,Dongju, AU - Liu,Lei, AU - Wang,Qin, AU - Zhang,Xiaona, AU - Ren,Juan, AU - Chen,Hong, Y1 - 2020/11/18/ PY - 2020/03/27/received PY - 2020/05/03/accepted PY - 2020/11/19/pubmed PY - 2021/1/2/medline PY - 2020/11/18/entrez KW - Coronavirus disease 2019 KW - Negative SARS-CoV-2 testing KW - Pneumonia KW - Positive SARS-CoV-2 testing KW - Risk factors SP - 739 EP - 747 JF - Respiration; international review of thoracic diseases JO - Respiration VL - 99 IS - 9 N2 - BACKGROUND: Coronavirus disease 2019 (COVID-19) has become a global emerging infectious disease. OBJECTIVES: To analyze the initial clinical characteristics of COVID-19 suspected and confirmed patients on admission in order to find out which kinds may be more likely to get positive nucleic acid testing results, and to explore the risk factors associated with all-cause death. METHODS: Medical records from 309 highly suspected cases with pneumonia were collected from February 13, 2020, to March 14, 2020, in a COVID-19-designated hospital of Wuhan. The majority of the clinical data were collected on the first day of hospital admission. RESULTS: Of 309 patients with median age 64 years (interquartile ranges [IQR], 53-72 years), 111 patients (35.9%) were confirmed by nucleic acid testing (median age 64 years, IQR: 56-71 years; 48 males). Of those 111 patients, 13 (11.7%) patients died. In multivariate analysis, factors associated with positive testing included fatigue (odds ratios [OR] = 3.14; 95% confidence interval [CI]: 1.88-5.24, p < 0.001), cough (OR = 0.55; 95% CI: 0.32-0.95, p = 0.032), no less than 1 comorbidity (OR = 1.77; 95% CI: 1.06-2.98, p = 0.030), and severe pneumonia (OR = 2.67; 95% CI: 1.20-5.97, p = 0.016). Furthermore, age, dyspnea, noneffective antibiotic treatment, white blood cell, lymphocyte, platelets, and organ dysfunction (e.g., higher lactate dehydrogenase) were significantly associated with all-cause in-hospital death in patients with COVID-19. CONCLUSION: Patients with severe forms of this disease were more likely to get positive results. Age and organ dysfunction were associated with a greater risk of death. SN - 1423-0356 UR - https://www.unboundmedicine.com/medline/citation/33207356/Factors_Associated_with_a_Positive_Severe_Acute_Respiratory_Syndrome_Coronavirus_2_Testing_in_Suspected_Cases_Presenting_with_Pneumonia:_A_Retrospective_Cohort_Study_in_a_Single_Medical_Center_ L2 - https://www.karger.com?DOI=10.1159/000508398 DB - PRIME DP - Unbound Medicine ER -