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Effects of Probiotic Preparations on Inflammatory Cytokines in Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis.
Curr Pharm Biotechnol. 2021; 22(10):1338-1349.CP

Abstract

OBJECTIVE

To summarize and assess the effects of probiotic preparations on inflammatory cytokine levels in patients with Chronic Kidney Disease (CKD).

METHODS

We searched through the PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), and Wan Fang databases for Randomized Controlled Trials (RCTs) that report the impact of probiotic preparations on inflammatory cytokines in CKD patients. Outcomes were composed of serum levels of CReactive Protein (CRP), Interleukin 6 (IL-6), Tumor Necrosis Factor-α (TNF-α), serum urea, creatinine, uric acid, Para-Cresol Sulfate (PCS), and Indoxyl-Sulfate (IS). The Mean Differences (MDs) with 95% Confidence Intervals (CIs) were considered as effect estimates. Sensitivity analysis and Egger's linear regression test were performed to evaluate the stability of results and publication bias. This study was registered with PROSPERO number CRD42020176557.

RESULTS AND DISCUSSION

Sixteen studies met the inclusion criteria. Evidence showed that serum CRP levels were decreased in the intervention group (WMD, -12.29, 95% CI, -16.41 to -8.16, p = 0). The IL-6 was significantly reduced only in the prebiotic group (SMD, -0.73, 95% CI, -1.3 to -0.16, p = 0.012). However, no reduction was observed in TNF-α (SMD, -0.07, 95% CI, -0.51 to 0.38, p = 0.772). Moreover, there was no significant change in serum uremic toxin, including creatine, urea, uric acid, PCS, and IS.

CONCLUSION

Probiotic preparations decrease the serum levels of inflammatory cytokines in CKD patients but do not affect the serum uremic toxin levels. The results of this meta-analysis suggest essential guidance for treatment decisions in clinical practice.

Authors+Show Affiliations

Department of Nephrology, the First Hospital of Shanxi Medicial University, Taiyuan, China.Renal Department, Shanxi Medicial University, Taiyuan, China.Renal Department, Shanxi Medicial University, Taiyuan, China.Department of Nephrology, the First Hospital of Shanxi Medicial University, Taiyuan, China.Department of Nephrology, the First Hospital of Shanxi Medicial University, Taiyuan, China.Department of Nephrology, the First Hospital of Shanxi Medicial University, Taiyuan, China.

Pub Type(s)

Meta-Analysis
Systematic Review

Language

eng

PubMed ID

33213338

Citation

Liu, Ting, et al. "Effects of Probiotic Preparations On Inflammatory Cytokines in Chronic Kidney Disease Patients: a Systematic Review and Meta-Analysis." Current Pharmaceutical Biotechnology, vol. 22, no. 10, 2021, pp. 1338-1349.
Liu T, Wang X, Li R, et al. Effects of Probiotic Preparations on Inflammatory Cytokines in Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis. Curr Pharm Biotechnol. 2021;22(10):1338-1349.
Liu, T., Wang, X., Li, R., Zhang, Z. Y., Fang, J., & Zhang, X. (2021). Effects of Probiotic Preparations on Inflammatory Cytokines in Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis. Current Pharmaceutical Biotechnology, 22(10), 1338-1349. https://doi.org/10.2174/1389201021666201119124058
Liu T, et al. Effects of Probiotic Preparations On Inflammatory Cytokines in Chronic Kidney Disease Patients: a Systematic Review and Meta-Analysis. Curr Pharm Biotechnol. 2021;22(10):1338-1349. PubMed PMID: 33213338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Probiotic Preparations on Inflammatory Cytokines in Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis. AU - Liu,Ting, AU - Wang,Xiaoxia, AU - Li,Rui, AU - Zhang,Zi Yuan, AU - Fang,Jingai, AU - Zhang,Xiaodong, PY - 2020/07/31/received PY - 2020/10/13/revised PY - 2020/10/21/accepted PY - 2020/11/21/pubmed PY - 2021/8/20/medline PY - 2020/11/20/entrez KW - Chronic kidney disease KW - inflammatory cytokine KW - meta-analysis. KW - probiotic preparation KW - systematic review KW - uremic toxin SP - 1338 EP - 1349 JF - Current pharmaceutical biotechnology JO - Curr Pharm Biotechnol VL - 22 IS - 10 N2 - OBJECTIVE: To summarize and assess the effects of probiotic preparations on inflammatory cytokine levels in patients with Chronic Kidney Disease (CKD). METHODS: We searched through the PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), and Wan Fang databases for Randomized Controlled Trials (RCTs) that report the impact of probiotic preparations on inflammatory cytokines in CKD patients. Outcomes were composed of serum levels of CReactive Protein (CRP), Interleukin 6 (IL-6), Tumor Necrosis Factor-α (TNF-α), serum urea, creatinine, uric acid, Para-Cresol Sulfate (PCS), and Indoxyl-Sulfate (IS). The Mean Differences (MDs) with 95% Confidence Intervals (CIs) were considered as effect estimates. Sensitivity analysis and Egger's linear regression test were performed to evaluate the stability of results and publication bias. This study was registered with PROSPERO number CRD42020176557. RESULTS AND DISCUSSION: Sixteen studies met the inclusion criteria. Evidence showed that serum CRP levels were decreased in the intervention group (WMD, -12.29, 95% CI, -16.41 to -8.16, p = 0). The IL-6 was significantly reduced only in the prebiotic group (SMD, -0.73, 95% CI, -1.3 to -0.16, p = 0.012). However, no reduction was observed in TNF-α (SMD, -0.07, 95% CI, -0.51 to 0.38, p = 0.772). Moreover, there was no significant change in serum uremic toxin, including creatine, urea, uric acid, PCS, and IS. CONCLUSION: Probiotic preparations decrease the serum levels of inflammatory cytokines in CKD patients but do not affect the serum uremic toxin levels. The results of this meta-analysis suggest essential guidance for treatment decisions in clinical practice. SN - 1873-4316 UR - https://www.unboundmedicine.com/medline/citation/33213338/Effects_of_Probiotic_Preparations_on_Inflammatory_Cytokines_in_Chronic_Kidney_Disease_Patients:_A_Systematic_Review_and_Meta_Analysis_ DB - PRIME DP - Unbound Medicine ER -