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Maternal clinical characteristics and perinatal outcomes among pregnant women with coronavirus disease 2019. A systematic review.
Travel Med Infect Dis. 2021 Jan-Feb; 39:101919.TM

Abstract

OBJECTIVE

To describe the maternal clinical characteristics, maternal and perinatal outcomes in COVID-19-positive pregnant women.

METHODS

Articles in all languages on the SARS-CoV-2 infection in pregnant women were sought from MEDLINE, EMBASE, Cochrane Library and LILACS; China National Knowledge Infrastructure Database (CNKI), Chinese Science and Technology Periodical Database (VIP) and Wan Fang Data between December 1, 2019 and April 27, 2020. Bulletins and national reports were also searched.

RESULTS

From 12,168 retrieved articles, 143 were selected for full-text assessment; 33 for descriptive analyses, and 4 case-controls for meta-analysis. In 322 infected pregnant women, aged 20-45 years, the most frequent maternal comorbidity was obesity (24.2%). Forty-two (28.4%) were asymptomatic at admission. Cough (n = 148,59.7%) and fever (n = 147,59.3%) were the most prevalent symptoms. In the meta-analysis, fever (OR: 0.13,95% CI 0.05 to 0.36) and cough (0.26,95% CI 0.11 to 0.59) were lower in pregnant women with COVID-19 than non-pregnant women with COVID-19.195 (60.6%) delivered, and 125 (38.8%) remained pregnant during the study. Cesarean was reported in 99 (50.8%) women and vaginal delivery in 64 (32.8%). The main adverse obstetric outcome was premature birth (n = 37,18.9%). Thirty patients (10.3%) with COVID-19-related complications required intensive care, one (0.3%) died. SARS-CoV-2 was absent in breast milk, amniotic fluid, placenta or umbilical cord blood.

CONCLUSIONS

The maternal clinical characteristics of COVID-19-positive pregnant include frequently fever and cough; however significantly less frequently than non-pregnant women with COVID-19. Iatrogenic preterm birth is the main adverse obstetric outcome. Current data does not support vertical transmission in the third trimester.

Authors+Show Affiliations

High-Risk Pregnancy Unit, Department of Obstetrics and Perinatology, Instituto Nacional Materno Perinatal, Lima, Peru; Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.High-Risk Pregnancy Unit, Department of Obstetrics and Perinatology, Instituto Nacional Materno Perinatal, Lima, Peru; Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.Residency Training Program in Obstetrics & Gynecology, Universidad Nacional Mayor de San Marcos, Lima, Peru.Residency Training Program in Obstetrics & Gynecology, Universidad Nacional Mayor de San Marcos, Lima, Peru.High-Risk Pregnancy Unit, Department of Obstetrics and Perinatology, Instituto Nacional Materno Perinatal, Lima, Peru; Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.Maternal & Fetal Medicine Unit, Department of Obstetrics and Perinatology, Instituto Nacional Materno Perinatal, Lima, Peru; Fetal Medicine Unit, Clínica Angloamericana, British Medical Hospital, Lima, Peru. Electronic address: wventura@angloamericana.com.pe.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

33220455

Citation

Novoa, Rommy H., et al. "Maternal Clinical Characteristics and Perinatal Outcomes Among Pregnant Women With Coronavirus Disease 2019. a Systematic Review." Travel Medicine and Infectious Disease, vol. 39, 2021, p. 101919.
Novoa RH, Quintana W, Llancarí P, et al. Maternal clinical characteristics and perinatal outcomes among pregnant women with coronavirus disease 2019. A systematic review. Travel Med Infect Dis. 2021;39:101919.
Novoa, R. H., Quintana, W., Llancarí, P., Urbina-Quispe, K., Guevara-Ríos, E., & Ventura, W. (2021). Maternal clinical characteristics and perinatal outcomes among pregnant women with coronavirus disease 2019. A systematic review. Travel Medicine and Infectious Disease, 39, 101919. https://doi.org/10.1016/j.tmaid.2020.101919
Novoa RH, et al. Maternal Clinical Characteristics and Perinatal Outcomes Among Pregnant Women With Coronavirus Disease 2019. a Systematic Review. Travel Med Infect Dis. 2021 Jan-Feb;39:101919. PubMed PMID: 33220455.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal clinical characteristics and perinatal outcomes among pregnant women with coronavirus disease 2019. A systematic review. AU - Novoa,Rommy H, AU - Quintana,Willy, AU - Llancarí,Pedro, AU - Urbina-Quispe,Katherine, AU - Guevara-Ríos,Enrique, AU - Ventura,Walter, Y1 - 2020/11/19/ PY - 2020/06/03/received PY - 2020/11/14/revised PY - 2020/11/16/accepted PY - 2020/11/22/pubmed PY - 2021/3/4/medline PY - 2020/11/21/entrez KW - COVID-19 KW - Coronavirus disease 2019 KW - Novel coronavirus KW - Perinatal outcome KW - Pregnancy KW - SARS-CoV-2 KW - Vertical transmission SP - 101919 EP - 101919 JF - Travel medicine and infectious disease JO - Travel Med Infect Dis VL - 39 N2 - OBJECTIVE: To describe the maternal clinical characteristics, maternal and perinatal outcomes in COVID-19-positive pregnant women. METHODS: Articles in all languages on the SARS-CoV-2 infection in pregnant women were sought from MEDLINE, EMBASE, Cochrane Library and LILACS; China National Knowledge Infrastructure Database (CNKI), Chinese Science and Technology Periodical Database (VIP) and Wan Fang Data between December 1, 2019 and April 27, 2020. Bulletins and national reports were also searched. RESULTS: From 12,168 retrieved articles, 143 were selected for full-text assessment; 33 for descriptive analyses, and 4 case-controls for meta-analysis. In 322 infected pregnant women, aged 20-45 years, the most frequent maternal comorbidity was obesity (24.2%). Forty-two (28.4%) were asymptomatic at admission. Cough (n = 148,59.7%) and fever (n = 147,59.3%) were the most prevalent symptoms. In the meta-analysis, fever (OR: 0.13,95% CI 0.05 to 0.36) and cough (0.26,95% CI 0.11 to 0.59) were lower in pregnant women with COVID-19 than non-pregnant women with COVID-19.195 (60.6%) delivered, and 125 (38.8%) remained pregnant during the study. Cesarean was reported in 99 (50.8%) women and vaginal delivery in 64 (32.8%). The main adverse obstetric outcome was premature birth (n = 37,18.9%). Thirty patients (10.3%) with COVID-19-related complications required intensive care, one (0.3%) died. SARS-CoV-2 was absent in breast milk, amniotic fluid, placenta or umbilical cord blood. CONCLUSIONS: The maternal clinical characteristics of COVID-19-positive pregnant include frequently fever and cough; however significantly less frequently than non-pregnant women with COVID-19. Iatrogenic preterm birth is the main adverse obstetric outcome. Current data does not support vertical transmission in the third trimester. SN - 1873-0442 UR - https://www.unboundmedicine.com/medline/citation/33220455/Maternal_clinical_characteristics_and_perinatal_outcomes_among_pregnant_women_with_coronavirus_disease_2019__A_systematic_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1477-8939(20)30415-4 DB - PRIME DP - Unbound Medicine ER -