Tags

Type your tag names separated by a space and hit enter

Synergistic Effect Of Oral Allopurinol And Intralesional Sodium Stibogluconate In The Treatment Of Cutaneous Leishmaniasis.
J Ayub Med Coll Abbottabad. 2020 Oct-Dec; 32(4):558-561.JA

Abstract

BACKGROUND

Leishmaniasis is an endemic disease and a major public health problem throughout the world. Its geographic distribution has been extended over the past few years in Pakistan. The available treatment options of Leishmaniasis are limited and mostly parenteral, and hence a nontoxic oral alternative therapy is urgently needed to overcome the problem. The objective of this study was to evaluate the synergistic effect of Allopurinol as an adjunct therapy along with conventional intra-lesional sodium Stibogluconate in the treatment of cutaneous Leishmaniasis.

METHODS

This single blinded randomized controlled trial was carried out at the tertiary care hospitals of district Peshawar, Pakistan. A total of one hundred and sixty-four (164) patients of age range from 19-56 years, consisting of both genders were included in this study. All subjects were randomly allocated to Group-1 and Group-2 where each group had 82 patients of comparable age and genders. Group-1 patients were given an intra-lesional injection of sodium Stibogluconate at a dose of 1-5 ml depending on the lesion size, where one ml injection contained 100 mg of the drug. Group-2 patients were given combination therapy of oral Allopurinol (20 mg/kg/day in divided doses) along with the same intra-lesional sodium Stibogluconate dose as group-1 until complete cure of the lesion.

RESULTS

Combination therapy of sodium Stibogluconate along with Allopurinol was found superior to sodium Stibogluconate alone in terms of duration of treatment. Group-1, patients who received only sodium Stibogluconate required prolonged treatment duration of 6-9 weeks depending upon the lesion size, while group-2 patients who received combination therapy of sodium Stibogluconate and Allopurinol responded more quickly and their lesions cured in 3-6 weeks depending upon the lesion size.

CONCLUSIONS

Oral Allopurinol has a synergistic effect when used with intra-lesional sodium Stibogluconate and effectively reduces the treatment duration required for complete cure of cutaneous Leishmaniasis. Treatment duration was reduced by 3 weeks in the present study when combination therapy was given to the patients of cutaneous Leishmaniasis.

Authors+Show Affiliations

Department of Pathology, Saidu Medical College, Swat, Pakistan.Department of Microbiology, IBMS, Khyber Medical University, Peshawar, Pakistan.IKD, Hayatabad Medical Complex Peshawar, Pakistan.District Medical Specialist, Peshawar, Pakistan.Department of Microbiology, KGMC, Peshawar, Pakistan.Department of Pathology, Khyber Medical College, Peshawar, Pakistan.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

33225663

Citation

Rashid, Haroon Ur, et al. "Synergistic Effect of Oral Allopurinol and Intralesional Sodium Stibogluconate in the Treatment of Cutaneous Leishmaniasis." Journal of Ayub Medical College, Abbottabad : JAMC, vol. 32, no. 4, 2020, pp. 558-561.
Rashid HU, Ullah I, Adeeb H, et al. Synergistic Effect Of Oral Allopurinol And Intralesional Sodium Stibogluconate In The Treatment Of Cutaneous Leishmaniasis. J Ayub Med Coll Abbottabad. 2020;32(4):558-561.
Rashid, H. U., Ullah, I., Adeeb, H., Zeb, M., Mohammad, A., & Rehman, N. (2020). Synergistic Effect Of Oral Allopurinol And Intralesional Sodium Stibogluconate In The Treatment Of Cutaneous Leishmaniasis. Journal of Ayub Medical College, Abbottabad : JAMC, 32(4), 558-561.
Rashid HU, et al. Synergistic Effect of Oral Allopurinol and Intralesional Sodium Stibogluconate in the Treatment of Cutaneous Leishmaniasis. J Ayub Med Coll Abbottabad. 2020 Oct-Dec;32(4):558-561. PubMed PMID: 33225663.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synergistic Effect Of Oral Allopurinol And Intralesional Sodium Stibogluconate In The Treatment Of Cutaneous Leishmaniasis. AU - Rashid,Haroon Ur, AU - Ullah,Ihsan, AU - Adeeb,Humera, AU - Zeb,Mubarak, AU - Mohammad,Amir, AU - Rehman,Naumana, PY - 2020/11/23/entrez PY - 2020/11/24/pubmed PY - 2021/4/27/medline KW - Allopurinol; Cutaneous leishmaniasis KW - Sodium Stibogluconate; Leishmania SP - 558 EP - 561 JF - Journal of Ayub Medical College, Abbottabad : JAMC JO - J Ayub Med Coll Abbottabad VL - 32 IS - 4 N2 - BACKGROUND: Leishmaniasis is an endemic disease and a major public health problem throughout the world. Its geographic distribution has been extended over the past few years in Pakistan. The available treatment options of Leishmaniasis are limited and mostly parenteral, and hence a nontoxic oral alternative therapy is urgently needed to overcome the problem. The objective of this study was to evaluate the synergistic effect of Allopurinol as an adjunct therapy along with conventional intra-lesional sodium Stibogluconate in the treatment of cutaneous Leishmaniasis. METHODS: This single blinded randomized controlled trial was carried out at the tertiary care hospitals of district Peshawar, Pakistan. A total of one hundred and sixty-four (164) patients of age range from 19-56 years, consisting of both genders were included in this study. All subjects were randomly allocated to Group-1 and Group-2 where each group had 82 patients of comparable age and genders. Group-1 patients were given an intra-lesional injection of sodium Stibogluconate at a dose of 1-5 ml depending on the lesion size, where one ml injection contained 100 mg of the drug. Group-2 patients were given combination therapy of oral Allopurinol (20 mg/kg/day in divided doses) along with the same intra-lesional sodium Stibogluconate dose as group-1 until complete cure of the lesion. RESULTS: Combination therapy of sodium Stibogluconate along with Allopurinol was found superior to sodium Stibogluconate alone in terms of duration of treatment. Group-1, patients who received only sodium Stibogluconate required prolonged treatment duration of 6-9 weeks depending upon the lesion size, while group-2 patients who received combination therapy of sodium Stibogluconate and Allopurinol responded more quickly and their lesions cured in 3-6 weeks depending upon the lesion size. CONCLUSIONS: Oral Allopurinol has a synergistic effect when used with intra-lesional sodium Stibogluconate and effectively reduces the treatment duration required for complete cure of cutaneous Leishmaniasis. Treatment duration was reduced by 3 weeks in the present study when combination therapy was given to the patients of cutaneous Leishmaniasis. SN - 1819-2718 UR - https://www.unboundmedicine.com/medline/citation/33225663/Synergistic_Effect_Of_Oral_Allopurinol_And_Intralesional_Sodium_Stibogluconate_In_The_Treatment_Of_Cutaneous_Leishmaniasis_ L2 - http://jamc.ayubmed.edu.pk/index.php/jamc/article/view/7428/2996 DB - PRIME DP - Unbound Medicine ER -