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HLA-DR, DP and DQ expression in the small intestine of patients with coeliac disease.
Clin Exp Immunol. 1987 Nov; 70(2):386-93.CE

Abstract

Frozen sections of jejunal mucosa from control subjects and patients with both treated and untreated coeliac disease were examined for HLA class II DR, DP and DQ expression. Different staining patterns with monoclonal antibodies to the different class II subgroups were observed with the control subjects. There was some inter-subject variation but in general DR greater than DP greater than DQ staining was observed with the villous enterocytes staining most strongly with the staining decreasing towards the crypt bases. The patients with treated coeliac disease gave a similar pattern to the controls. The patients with untreated coeliac disease generally gave a more intense and relatively uniform staining of both surface and crypt enterocytes for all class II subgroups.

Authors+Show Affiliations

Department of Histopathology, Rayne Institute, St Thomas' Hospital, London, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3322617

Citation

Marley, N J., et al. "HLA-DR, DP and DQ Expression in the Small Intestine of Patients With Coeliac Disease." Clinical and Experimental Immunology, vol. 70, no. 2, 1987, pp. 386-93.
Marley NJ, Macartney JC, Ciclitira PJ. HLA-DR, DP and DQ expression in the small intestine of patients with coeliac disease. Clin Exp Immunol. 1987;70(2):386-93.
Marley, N. J., Macartney, J. C., & Ciclitira, P. J. (1987). HLA-DR, DP and DQ expression in the small intestine of patients with coeliac disease. Clinical and Experimental Immunology, 70(2), 386-93.
Marley NJ, Macartney JC, Ciclitira PJ. HLA-DR, DP and DQ Expression in the Small Intestine of Patients With Coeliac Disease. Clin Exp Immunol. 1987;70(2):386-93. PubMed PMID: 3322617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA-DR, DP and DQ expression in the small intestine of patients with coeliac disease. AU - Marley,N J, AU - Macartney,J C, AU - Ciclitira,P J, PY - 1987/11/1/pubmed PY - 1987/11/1/medline PY - 1987/11/1/entrez SP - 386 EP - 93 JF - Clinical and experimental immunology JO - Clin Exp Immunol VL - 70 IS - 2 N2 - Frozen sections of jejunal mucosa from control subjects and patients with both treated and untreated coeliac disease were examined for HLA class II DR, DP and DQ expression. Different staining patterns with monoclonal antibodies to the different class II subgroups were observed with the control subjects. There was some inter-subject variation but in general DR greater than DP greater than DQ staining was observed with the villous enterocytes staining most strongly with the staining decreasing towards the crypt bases. The patients with treated coeliac disease gave a similar pattern to the controls. The patients with untreated coeliac disease generally gave a more intense and relatively uniform staining of both surface and crypt enterocytes for all class II subgroups. SN - 0009-9104 UR - https://www.unboundmedicine.com/medline/citation/3322617/HLA_DR_DP_and_DQ_expression_in_the_small_intestine_of_patients_with_coeliac_disease_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/3322617/ DB - PRIME DP - Unbound Medicine ER -