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Risk factors for progression and prognosis of primary Sjögren's syndrome-associated interstitial lung disease in a Chinese population.
Int J Rheum Dis. 2020 Dec; 23(12):1734-1740.IJ

Abstract

OBJECTIVE

This study explored differences between primary Sjögren's syndrome-associated interstitial lung disease (pSS-ILD) patients with and without ILD progression, and analyzed the factors affecting the progression and prognosis of pSS-ILD.

METHODS

This study is a retrospective cohort study which enrolled 113 pSS-ILD patients hospitalized between 2011 and 2017.

RESULTS

The 3-year survival rate of the pSS-ILD patients was 91.15%, and the 5-year survival rate was 84.07%. Univariate analysis showed that Raynaud's syndrome, hypoproteinemia, extensive lung involvement, possible usual interstitial pneumonia pattern were risk factors for the progression of ILD in patients with pSS-ILD, and cyclophosphamide was a protective factor for the progression of ILD in patients with pSS-ILD. Multiple logistic regression analysis showed that extensive lung involvement (odds ratio 4.143, 95% CI: 1.203-14.267, P < .05) was an independent risk factor for the progression of pSS-ILD. Cox hazard analysis showed that pSS-ILD with hypoproteinemia (hazard ratio [HR] 17.758, 95% CI: 4.753-66.340, P <- .05) and extensive lung involvement (HR 3.450, 95% CI: 1.419-8.390, P < .05) were associated with worse survival of patients.

CONCLUSION

Extensive lung involvement is an independent risk factor for the progression of ILD in patients with pSS-ILD. Hypoproteinemia and extensive lung involvement are independent risk factors for mortality in patients with pSS-ILD, after controlling for potentially influential variables.

Authors+Show Affiliations

Department of Rheumatology and Immunology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.Department of Rheumatology and immunology, Henan Province People's Hospital, Zhengzhou City, China.Department of Rheumatology and Immunology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.Department of Rheumatology and Immunology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.Department of Rheumatology and Immunology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33226736

Citation

Xu, Yuetong, et al. "Risk Factors for Progression and Prognosis of Primary Sjögren's Syndrome-associated Interstitial Lung Disease in a Chinese Population." International Journal of Rheumatic Diseases, vol. 23, no. 12, 2020, pp. 1734-1740.
Xu Y, Zhou J, Dong X, et al. Risk factors for progression and prognosis of primary Sjögren's syndrome-associated interstitial lung disease in a Chinese population. Int J Rheum Dis. 2020;23(12):1734-1740.
Xu, Y., Zhou, J., Dong, X., Guo, X., Lu, Y., & Zheng, Y. (2020). Risk factors for progression and prognosis of primary Sjögren's syndrome-associated interstitial lung disease in a Chinese population. International Journal of Rheumatic Diseases, 23(12), 1734-1740. https://doi.org/10.1111/1756-185X.14023
Xu Y, et al. Risk Factors for Progression and Prognosis of Primary Sjögren's Syndrome-associated Interstitial Lung Disease in a Chinese Population. Int J Rheum Dis. 2020;23(12):1734-1740. PubMed PMID: 33226736.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for progression and prognosis of primary Sjögren's syndrome-associated interstitial lung disease in a Chinese population. AU - Xu,Yuetong, AU - Zhou,Junfei, AU - Dong,Xin, AU - Guo,Xiaojuan, AU - Lu,Yuewu, AU - Zheng,Yi, Y1 - 2020/11/23/ PY - 2020/06/01/received PY - 2020/09/12/revised PY - 2020/10/15/accepted PY - 2020/11/24/pubmed PY - 2021/10/12/medline PY - 2020/11/23/entrez KW - interstitial lung disease KW - primary Sjögren's syndrome KW - prognostic factors KW - progression SP - 1734 EP - 1740 JF - International journal of rheumatic diseases JO - Int J Rheum Dis VL - 23 IS - 12 N2 - OBJECTIVE: This study explored differences between primary Sjögren's syndrome-associated interstitial lung disease (pSS-ILD) patients with and without ILD progression, and analyzed the factors affecting the progression and prognosis of pSS-ILD. METHODS: This study is a retrospective cohort study which enrolled 113 pSS-ILD patients hospitalized between 2011 and 2017. RESULTS: The 3-year survival rate of the pSS-ILD patients was 91.15%, and the 5-year survival rate was 84.07%. Univariate analysis showed that Raynaud's syndrome, hypoproteinemia, extensive lung involvement, possible usual interstitial pneumonia pattern were risk factors for the progression of ILD in patients with pSS-ILD, and cyclophosphamide was a protective factor for the progression of ILD in patients with pSS-ILD. Multiple logistic regression analysis showed that extensive lung involvement (odds ratio 4.143, 95% CI: 1.203-14.267, P < .05) was an independent risk factor for the progression of pSS-ILD. Cox hazard analysis showed that pSS-ILD with hypoproteinemia (hazard ratio [HR] 17.758, 95% CI: 4.753-66.340, P <- .05) and extensive lung involvement (HR 3.450, 95% CI: 1.419-8.390, P < .05) were associated with worse survival of patients. CONCLUSION: Extensive lung involvement is an independent risk factor for the progression of ILD in patients with pSS-ILD. Hypoproteinemia and extensive lung involvement are independent risk factors for mortality in patients with pSS-ILD, after controlling for potentially influential variables. SN - 1756-185X UR - https://www.unboundmedicine.com/medline/citation/33226736/Risk_factors_for_progression_and_prognosis_of_primary_Sjögren's_syndrome_associated_interstitial_lung_disease_in_a_Chinese_population_ L2 - https://doi.org/10.1111/1756-185X.14023 DB - PRIME DP - Unbound Medicine ER -