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Clinical effects of diaper types on the skin of normal infants and infants with atopic dermatitis.
J Am Acad Dermatol. 1987 Dec; 17(6):988-97.JA

Abstract

Cloth diapers, cellulose core diapers (conventional disposable diapers), and cellulose core diapers containing absorbent gelling material were examined for their effects on diaper rash and skin microbiology of normal infants and infants with atopic dermatitis in a 26-week double-blind clinical trial. Infants with atopic dermatitis wearing the diapers containing absorbent gelling material had significantly lower diaper rash grades than infants with atopic dermatitis wearing cloth diapers at five of eight grading visits. Infants with atopic dermatitis wearing conventional cellulose core diapers had statistically less rash at one of eight visits. There was no statistically significant difference between diaper types at three of the eight visits. At no time did the cloth group have less diaper rash than the conventional cellulose or absorbent gelling material disposable diaper group. A statistical correlation between the severity of general atopic dermatitis outside the diaper area and the diaper rash condition under the diaper occurred only in the atopic dermatitis group wearing cloth diapers. Isolation of microorganisms from the intact, uninvolved skin surface both inside and outside the diaper showed no biologically significant changes in the presence or numbers of selected skin organisms. Repeated isolation, at multiple grading visits of Staphylococcus aureus from uncompromised skin inside the diaper area was infrequent but correlated with the diagnosis of atopic dermatitis when observed.

Authors+Show Affiliations

Procter & Gamble Company, Human Safety Section, Cincinnati, OH 45224.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

3323275

Citation

Seymour, J L., et al. "Clinical Effects of Diaper Types On the Skin of Normal Infants and Infants With Atopic Dermatitis." Journal of the American Academy of Dermatology, vol. 17, no. 6, 1987, pp. 988-97.
Seymour JL, Keswick BH, Hanifin JM, et al. Clinical effects of diaper types on the skin of normal infants and infants with atopic dermatitis. J Am Acad Dermatol. 1987;17(6):988-97.
Seymour, J. L., Keswick, B. H., Hanifin, J. M., Jordan, W. P., & Milligan, M. C. (1987). Clinical effects of diaper types on the skin of normal infants and infants with atopic dermatitis. Journal of the American Academy of Dermatology, 17(6), 988-97.
Seymour JL, et al. Clinical Effects of Diaper Types On the Skin of Normal Infants and Infants With Atopic Dermatitis. J Am Acad Dermatol. 1987;17(6):988-97. PubMed PMID: 3323275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical effects of diaper types on the skin of normal infants and infants with atopic dermatitis. AU - Seymour,J L, AU - Keswick,B H, AU - Hanifin,J M, AU - Jordan,W P, AU - Milligan,M C, PY - 1987/12/1/pubmed PY - 1987/12/1/medline PY - 1987/12/1/entrez SP - 988 EP - 97 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 17 IS - 6 N2 - Cloth diapers, cellulose core diapers (conventional disposable diapers), and cellulose core diapers containing absorbent gelling material were examined for their effects on diaper rash and skin microbiology of normal infants and infants with atopic dermatitis in a 26-week double-blind clinical trial. Infants with atopic dermatitis wearing the diapers containing absorbent gelling material had significantly lower diaper rash grades than infants with atopic dermatitis wearing cloth diapers at five of eight grading visits. Infants with atopic dermatitis wearing conventional cellulose core diapers had statistically less rash at one of eight visits. There was no statistically significant difference between diaper types at three of the eight visits. At no time did the cloth group have less diaper rash than the conventional cellulose or absorbent gelling material disposable diaper group. A statistical correlation between the severity of general atopic dermatitis outside the diaper area and the diaper rash condition under the diaper occurred only in the atopic dermatitis group wearing cloth diapers. Isolation of microorganisms from the intact, uninvolved skin surface both inside and outside the diaper showed no biologically significant changes in the presence or numbers of selected skin organisms. Repeated isolation, at multiple grading visits of Staphylococcus aureus from uncompromised skin inside the diaper area was infrequent but correlated with the diagnosis of atopic dermatitis when observed. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/3323275/Clinical_effects_of_diaper_types_on_the_skin_of_normal_infants_and_infants_with_atopic_dermatitis_ DB - PRIME DP - Unbound Medicine ER -