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Relationship between digestive diseases and COVID-19 severity and mortality: A protocol for systematic review and meta-analysis.
Medicine (Baltimore). 2020 Nov 25; 99(48):e23353.M

Abstract

BACKGROUND

Digestive diseases have been often reported in COVID-19 patients, but whether COVID-19 patients with existing digestive comorbidities are at an increased risk of serious disease and death remains unclear. This study aims to evaluate the association between digestive diseases and COVID-19 severity and mortality.

METHODS

PubMed, Embase.com, the Cochrane Central Register of Controlled Trials, Web of Science, China National Knowledge Infrastructure, Wanfang, and SinoMed will be searched to identify relevant studies up to October 1, 2020. We will use the Newcastle-Ottawa quality assessment scale to assess the quality of included studies. We will use Stata to perform pairwise meta-analyses using the random-effects model with the inverse variance method to estimate the association between digestive diseases and the mortality and severity of COVID-19. Subgroup analyses and sensitivity analyses will be conducted to investigate the sources of heterogeneity. We will create a "Summary of findings' table presenting our primary and secondary outcomes using the GRADEpro Guideline Development Tool software.

RESULTS

The results of this study will be published in a peer-reviewed journal.

CONCLUSIONS

This study will comprehensively evaluate the association between digestive diseases and the severity and mortality of patients with COVID-19. The results of this study will provide high-quality evidence to support clinical practice and guidelines development.

Authors+Show Affiliations

School of Public Health, Gansu University of Chinese Medicine.School of Public Health, Gansu University of Chinese Medicine.School of Public Health, Gansu University of Chinese Medicine.School of Public Health, Gansu University of Chinese Medicine.The First Clinical Medical College of Lanzhou University.The First Clinical Medical College of Lanzhou University.Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, China.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

33235103

Citation

Li, Jinjuan, et al. "Relationship Between Digestive Diseases and COVID-19 Severity and Mortality: a Protocol for Systematic Review and Meta-analysis." Medicine, vol. 99, no. 48, 2020, pp. e23353.
Li J, Yue J, Zhang S, et al. Relationship between digestive diseases and COVID-19 severity and mortality: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2020;99(48):e23353.
Li, J., Yue, J., Zhang, S., Wu, J., Lian, R., Zhang, R., & Cheng, P. (2020). Relationship between digestive diseases and COVID-19 severity and mortality: A protocol for systematic review and meta-analysis. Medicine, 99(48), e23353. https://doi.org/10.1097/MD.0000000000023353
Li J, et al. Relationship Between Digestive Diseases and COVID-19 Severity and Mortality: a Protocol for Systematic Review and Meta-analysis. Medicine (Baltimore). 2020 Nov 25;99(48):e23353. PubMed PMID: 33235103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between digestive diseases and COVID-19 severity and mortality: A protocol for systematic review and meta-analysis. AU - Li,Jinjuan, AU - Yue,Jia, AU - Zhang,Shunan, AU - Wu,Jianjun, AU - Lian,Rongna, AU - Zhang,Ruinian, AU - Cheng,Peng, PY - 2020/11/25/entrez PY - 2020/11/26/pubmed PY - 2020/11/26/medline SP - e23353 EP - e23353 JF - Medicine JO - Medicine (Baltimore) VL - 99 IS - 48 N2 - BACKGROUND: Digestive diseases have been often reported in COVID-19 patients, but whether COVID-19 patients with existing digestive comorbidities are at an increased risk of serious disease and death remains unclear. This study aims to evaluate the association between digestive diseases and COVID-19 severity and mortality. METHODS: PubMed, Embase.com, the Cochrane Central Register of Controlled Trials, Web of Science, China National Knowledge Infrastructure, Wanfang, and SinoMed will be searched to identify relevant studies up to October 1, 2020. We will use the Newcastle-Ottawa quality assessment scale to assess the quality of included studies. We will use Stata to perform pairwise meta-analyses using the random-effects model with the inverse variance method to estimate the association between digestive diseases and the mortality and severity of COVID-19. Subgroup analyses and sensitivity analyses will be conducted to investigate the sources of heterogeneity. We will create a "Summary of findings' table presenting our primary and secondary outcomes using the GRADEpro Guideline Development Tool software. RESULTS: The results of this study will be published in a peer-reviewed journal. CONCLUSIONS: This study will comprehensively evaluate the association between digestive diseases and the severity and mortality of patients with COVID-19. The results of this study will provide high-quality evidence to support clinical practice and guidelines development. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/33235103/Relationship_between_digestive_diseases_and_COVID_19_severity_and_mortality:_A_protocol_for_systematic_review_and_meta_analysis_ L2 - https://doi.org/10.1097/MD.0000000000023353 DB - PRIME DP - Unbound Medicine ER -