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Effects of a selective thromboxane synthetase inhibitor (OKY-046) in patients with coronary artery disease during exercise.
Jpn Heart J. 1987 Sep; 28(5):663-74.JH

Abstract

We studied the levels of thromboxane B2 (TXB2), 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), platelet aggregability, beta-thromboglobulin and platelet factor 4 in 30 coronary artery disease (CAD) patients and 21 normal subjects during exercise. During treadmill exercise, 13 of 30 CAD patients reported chest pain. We administered a selective thromboxane synthetase inhibitor (OKY-046) for 2 weeks to 10 CAD patients with exercise-induced chest pain and studied its effects. At rest, the plasma TXB2 levels and platelet aggregation were significantly lower in normal subjects than in CAD patients, and there was no difference between CAD patients with and without exercise-induced chest pain. On treadmill testing, plasma TXB2 levels and platelet aggregation increased significantly only in the CAD patients with exercise-induced chest pain. Plasma 6-keto-PGF1 alpha levels in normal subjects were significantly higher than those in CAD patients both at rest and during exercise. After administration of OKY-046, mean exercise time increased significantly from 7.5 to 8.6 min (p less than 0.001). Plasma TXB2 level and platelet aggregation decreased significantly after OKY-046 administration both at rest and during exercise. These results suggest that a marked increase in TXA2, with only a minimal change in PGI2, during exercise may contribute to exercise-induced myocardial ischemia, and that OKY-046 is useful in the treatment of CAD patients.

Authors+Show Affiliations

Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3323562

Citation

Shikano, M, et al. "Effects of a Selective Thromboxane Synthetase Inhibitor (OKY-046) in Patients With Coronary Artery Disease During Exercise." Japanese Heart Journal, vol. 28, no. 5, 1987, pp. 663-74.
Shikano M, Ito T, Ogawa K, et al. Effects of a selective thromboxane synthetase inhibitor (OKY-046) in patients with coronary artery disease during exercise. Jpn Heart J. 1987;28(5):663-74.
Shikano, M., Ito, T., Ogawa, K., & Satake, T. (1987). Effects of a selective thromboxane synthetase inhibitor (OKY-046) in patients with coronary artery disease during exercise. Japanese Heart Journal, 28(5), 663-74.
Shikano M, et al. Effects of a Selective Thromboxane Synthetase Inhibitor (OKY-046) in Patients With Coronary Artery Disease During Exercise. Jpn Heart J. 1987;28(5):663-74. PubMed PMID: 3323562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a selective thromboxane synthetase inhibitor (OKY-046) in patients with coronary artery disease during exercise. AU - Shikano,M, AU - Ito,T, AU - Ogawa,K, AU - Satake,T, PY - 1987/9/1/pubmed PY - 1987/9/1/medline PY - 1987/9/1/entrez SP - 663 EP - 74 JF - Japanese heart journal JO - Jpn Heart J VL - 28 IS - 5 N2 - We studied the levels of thromboxane B2 (TXB2), 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), platelet aggregability, beta-thromboglobulin and platelet factor 4 in 30 coronary artery disease (CAD) patients and 21 normal subjects during exercise. During treadmill exercise, 13 of 30 CAD patients reported chest pain. We administered a selective thromboxane synthetase inhibitor (OKY-046) for 2 weeks to 10 CAD patients with exercise-induced chest pain and studied its effects. At rest, the plasma TXB2 levels and platelet aggregation were significantly lower in normal subjects than in CAD patients, and there was no difference between CAD patients with and without exercise-induced chest pain. On treadmill testing, plasma TXB2 levels and platelet aggregation increased significantly only in the CAD patients with exercise-induced chest pain. Plasma 6-keto-PGF1 alpha levels in normal subjects were significantly higher than those in CAD patients both at rest and during exercise. After administration of OKY-046, mean exercise time increased significantly from 7.5 to 8.6 min (p less than 0.001). Plasma TXB2 level and platelet aggregation decreased significantly after OKY-046 administration both at rest and during exercise. These results suggest that a marked increase in TXA2, with only a minimal change in PGI2, during exercise may contribute to exercise-induced myocardial ischemia, and that OKY-046 is useful in the treatment of CAD patients. SN - 0021-4868 UR - https://www.unboundmedicine.com/medline/citation/3323562/Effects_of_a_selective_thromboxane_synthetase_inhibitor__OKY_046__in_patients_with_coronary_artery_disease_during_exercise_ DB - PRIME DP - Unbound Medicine ER -