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Duration of seropositivity following yellow fever vaccination in U.S. military service members.
Vaccine. 2020 12 14; 38(52):8286-8291.V

Abstract

BACKGROUND

The United States military regularly deploys thousands of service members throughout areas of South America and Africa that are endemic for yellow fever (YF) virus. To determine if booster doses might be needed for service members who are repetitively or continually deployed to YF endemic areas, we evaluated seropositivity among US military personnel receiving a single dose of YF vaccine based on time post-vaccination.

METHODS

Serum antibodies were measured using a plaque reduction neutralization test with 50% cutoff in 682 military personnel at 5-39 years post-vaccination. We determined noninferiority of immune response by comparing the proportion seropositive among those vaccinated 10-14 years previously with those vaccinated 5-9 years previously. Noninferiority was supported if the lower-bound of the 2-tailed 95% CI for p10-14years - p5-9years was ≥-0.10. Additionally, the geometric mean antibody titer (GMT) at various timepoints following vaccination were compared to the GMT at 5-9 years.

RESULTS

The proportion of military service members with detectable neutralizing antibodies 10-14 years after a single dose of YF vaccine (95.8%, 95% CI 91.2-98.1%) was non-inferior to the proportion 5-9 years after vaccination (97.8%, 95% CI 93.7-99.3%). Additionally, GMT among vaccine recipients at 10-14 years post vaccination (99, 95% CI 82-121) was non-inferior to GMT in YF vaccine recipients at 5-9 years post vaccination (115, 95% CI 96-139). The proportion of vaccinees with neutralizing antibodies remained high, and non-inferior, among those vaccinated 15-19 years prior (98.5%, 95%CI 95.5-99.7%). Although the proportion seropositive decreased among vaccinees ≥ 20 years post vaccination, >90% remained seropositive.

CONCLUSIONS

Neutralizing antibodies were present in > 95% of vaccine recipients for at least 19 years after vaccination, suggesting that booster doses every 10 years are not essential for most U.S. military personnel.

Authors+Show Affiliations

Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, United States. Electronic address: nplindsey@cdc.gov.Operational Infectious Diseases Directorate, Naval Health Research Center, San Diego, CA, United States.Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, United States.Operational Infectious Diseases Directorate, Naval Health Research Center, San Diego, CA, United States.Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, United States.Operational Infectious Diseases Directorate, Naval Health Research Center, San Diego, CA, United States.Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, United States.Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, United States.Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, United States.Operational Infectious Diseases Directorate, Naval Health Research Center, San Diego, CA, United States.Operational Infectious Diseases Directorate, Naval Health Research Center, San Diego, CA, United States.Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, United States.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33239225

Citation

Lindsey, Nicole P., et al. "Duration of Seropositivity Following Yellow Fever Vaccination in U.S. Military Service Members." Vaccine, vol. 38, no. 52, 2020, pp. 8286-8291.
Lindsey NP, Perry L, Fischer M, et al. Duration of seropositivity following yellow fever vaccination in U.S. military service members. Vaccine. 2020;38(52):8286-8291.
Lindsey, N. P., Perry, L., Fischer, M., Woolpert, T., Biggerstaff, B. J., Brice, G., Fitzpatrick, K., Kosoy, O. I., Laven, J. J., Myers, C. A., Hollis, E. M., & Staples, J. E. (2020). Duration of seropositivity following yellow fever vaccination in U.S. military service members. Vaccine, 38(52), 8286-8291. https://doi.org/10.1016/j.vaccine.2020.11.022
Lindsey NP, et al. Duration of Seropositivity Following Yellow Fever Vaccination in U.S. Military Service Members. Vaccine. 2020 12 14;38(52):8286-8291. PubMed PMID: 33239225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Duration of seropositivity following yellow fever vaccination in U.S. military service members. AU - Lindsey,Nicole P, AU - Perry,Lori, AU - Fischer,Marc, AU - Woolpert,Tabitha, AU - Biggerstaff,Brad J, AU - Brice,Gary, AU - Fitzpatrick,Kelly, AU - Kosoy,Olga I, AU - Laven,Janeen J, AU - Myers,Christopher A, AU - Hollis,Ewell M, AU - Staples,J Erin, Y1 - 2020/11/22/ PY - 2020/09/10/received PY - 2020/11/06/revised PY - 2020/11/08/accepted PY - 2020/11/27/pubmed PY - 2021/4/28/medline PY - 2020/11/26/entrez KW - Military KW - Seropositivity KW - Vaccine KW - Yellow fever SP - 8286 EP - 8291 JF - Vaccine JO - Vaccine VL - 38 IS - 52 N2 - BACKGROUND: The United States military regularly deploys thousands of service members throughout areas of South America and Africa that are endemic for yellow fever (YF) virus. To determine if booster doses might be needed for service members who are repetitively or continually deployed to YF endemic areas, we evaluated seropositivity among US military personnel receiving a single dose of YF vaccine based on time post-vaccination. METHODS: Serum antibodies were measured using a plaque reduction neutralization test with 50% cutoff in 682 military personnel at 5-39 years post-vaccination. We determined noninferiority of immune response by comparing the proportion seropositive among those vaccinated 10-14 years previously with those vaccinated 5-9 years previously. Noninferiority was supported if the lower-bound of the 2-tailed 95% CI for p10-14years - p5-9years was ≥-0.10. Additionally, the geometric mean antibody titer (GMT) at various timepoints following vaccination were compared to the GMT at 5-9 years. RESULTS: The proportion of military service members with detectable neutralizing antibodies 10-14 years after a single dose of YF vaccine (95.8%, 95% CI 91.2-98.1%) was non-inferior to the proportion 5-9 years after vaccination (97.8%, 95% CI 93.7-99.3%). Additionally, GMT among vaccine recipients at 10-14 years post vaccination (99, 95% CI 82-121) was non-inferior to GMT in YF vaccine recipients at 5-9 years post vaccination (115, 95% CI 96-139). The proportion of vaccinees with neutralizing antibodies remained high, and non-inferior, among those vaccinated 15-19 years prior (98.5%, 95%CI 95.5-99.7%). Although the proportion seropositive decreased among vaccinees ≥ 20 years post vaccination, >90% remained seropositive. CONCLUSIONS: Neutralizing antibodies were present in > 95% of vaccine recipients for at least 19 years after vaccination, suggesting that booster doses every 10 years are not essential for most U.S. military personnel. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/33239225/Duration_of_seropositivity_following_yellow_fever_vaccination_in_U_S__military_service_members_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(20)31462-6 DB - PRIME DP - Unbound Medicine ER -