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Convalescent Memory T Cell Immunity in Individuals with Mild or Asymptomatic SARS-CoV-2 Infection May Result from an Evolutionarily Adapted Immune Response to Coronavirus and the 'Common Cold'.
Med Sci Monit. 2020 Nov 26; 26:e929789.MS

Abstract

Recent studies have shown a significant level of T cell immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in convalescent coronavirus disease 2019 (COVID-19) patients and unexposed healthy individuals. Also, SARS-CoV-2-reactive T memory cells occur in unexposed healthy individuals from endemic coronaviruses that cause the 'common cold.' The finding of the expression of adaptive SARS-CoV-2-reactive T memory cells in unexposed healthy individuals may be due to multiple cross-reactive viral protein targets following previous exposure to endemic human coronavirus infections. The opinion of the authors is that determination of protein sequence homologies across seemingly disparate viral protein libraries may provide epitope-matching data that link SARS-CoV-2-reactive T memory cell signatures to prior administration of cross-reacting vaccines to common viral pathogens. Exposure to SARS-CoV-2 initiates diverse cellular immune responses, including the associated 'cytokine storm'. Therefore, it is possible that the intact virus possesses a required degree of conformational matching, or stereoselectivity, to effectively target its receptor on multiple cell types. Therefore, conformational matching may be viewed as an evolving mechanism of viral infection and viral replication by an evolutionary modification of the angiotensin-converting enzyme 2 (ACE2) receptor required for SARS-CoV-2 binding and host cell entry. The authors propose that convalescent memory T cell immunity in individuals with mild or asymptomatic SARS-CoV-2 infection may result from an evolutionarily adapted immune response to coronavirus and the 'common cold'.

Authors+Show Affiliations

International Scientific Information, Inc., Melville, NY, USA. Center for Cognitive and Molecular Neuroscience, First Faculty of Medicine Charles University in Prague, Prague, Czech Republic.International Scientific Information, Inc., Melville, NY, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33239605

Citation

Stefano, George B., and Richard M. Kream. "Convalescent Memory T Cell Immunity in Individuals With Mild or Asymptomatic SARS-CoV-2 Infection May Result From an Evolutionarily Adapted Immune Response to Coronavirus and the 'Common Cold'." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 26, 2020, pp. e929789.
Stefano GB, Kream RM. Convalescent Memory T Cell Immunity in Individuals with Mild or Asymptomatic SARS-CoV-2 Infection May Result from an Evolutionarily Adapted Immune Response to Coronavirus and the 'Common Cold'. Med Sci Monit. 2020;26:e929789.
Stefano, G. B., & Kream, R. M. (2020). Convalescent Memory T Cell Immunity in Individuals with Mild or Asymptomatic SARS-CoV-2 Infection May Result from an Evolutionarily Adapted Immune Response to Coronavirus and the 'Common Cold'. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 26, e929789. https://doi.org/10.12659/MSM.929789
Stefano GB, Kream RM. Convalescent Memory T Cell Immunity in Individuals With Mild or Asymptomatic SARS-CoV-2 Infection May Result From an Evolutionarily Adapted Immune Response to Coronavirus and the 'Common Cold'. Med Sci Monit. 2020 Nov 26;26:e929789. PubMed PMID: 33239605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Convalescent Memory T Cell Immunity in Individuals with Mild or Asymptomatic SARS-CoV-2 Infection May Result from an Evolutionarily Adapted Immune Response to Coronavirus and the 'Common Cold'. AU - Stefano,George B, AU - Kream,Richard M, Y1 - 2020/11/26/ PY - 2020/11/26/entrez PY - 2020/11/27/pubmed PY - 2021/1/7/medline SP - e929789 EP - e929789 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med Sci Monit VL - 26 N2 - Recent studies have shown a significant level of T cell immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in convalescent coronavirus disease 2019 (COVID-19) patients and unexposed healthy individuals. Also, SARS-CoV-2-reactive T memory cells occur in unexposed healthy individuals from endemic coronaviruses that cause the 'common cold.' The finding of the expression of adaptive SARS-CoV-2-reactive T memory cells in unexposed healthy individuals may be due to multiple cross-reactive viral protein targets following previous exposure to endemic human coronavirus infections. The opinion of the authors is that determination of protein sequence homologies across seemingly disparate viral protein libraries may provide epitope-matching data that link SARS-CoV-2-reactive T memory cell signatures to prior administration of cross-reacting vaccines to common viral pathogens. Exposure to SARS-CoV-2 initiates diverse cellular immune responses, including the associated 'cytokine storm'. Therefore, it is possible that the intact virus possesses a required degree of conformational matching, or stereoselectivity, to effectively target its receptor on multiple cell types. Therefore, conformational matching may be viewed as an evolving mechanism of viral infection and viral replication by an evolutionary modification of the angiotensin-converting enzyme 2 (ACE2) receptor required for SARS-CoV-2 binding and host cell entry. The authors propose that convalescent memory T cell immunity in individuals with mild or asymptomatic SARS-CoV-2 infection may result from an evolutionarily adapted immune response to coronavirus and the 'common cold'. SN - 1643-3750 UR - https://www.unboundmedicine.com/medline/citation/33239605/Convalescent_Memory_T_Cell_Immunity_in_Individuals_with_Mild_or_Asymptomatic_SARS_CoV_2_Infection_May_Result_from_an_Evolutionarily_Adapted_Immune_Response_to_Coronavirus_and_the_'Common_Cold'_ L2 - https://www.medscimonit.com/download/index/idArt/929789 DB - PRIME DP - Unbound Medicine ER -