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Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort.
Environ Health. 2020 11 26; 19(1):127.EH

Abstract

BACKGROUND

Evidence of associations between prenatal exposure to perfluoroalkyl substances (PFASs) and fetal thyroid hormones (THs) is controversial, and few studies have estimated the associations, while addressing the high correlations among multiple PFASs. We aimed to examine the associations between prenatal PFAS exposure and thyroid hormone concentrations in cord blood.

METHODS

A total of 300 mother-infant pairs from the Shanghai-Minhang Birth Cohort Study were included. We measured the concentrations of eight PFASs in maternal plasma samples collected at 12-16 gestational weeks, as well as those of total thyroxine (T4), free T4 (FT4), total triiodothyronine (T3), free T3 (FT3), and thyroid stimulating hormone (TSH) in cord plasma. We estimated the associations between maternal PFAS concentrations and TH concentrations using linear regression and Bayesian kernel machine regression (BKMR) models.

RESULTS

In BKMR models, higher PFAS mixture concentrations were associated with increased T3 concentrations, and there were suggestive associations with increased FT3 concentrations. For single-exposure effects in BKMR models, a change in PFDA, PFUdA, and PFOA concentrations from the 25th to 75th percentile was associated with a 0.04 (95%CrI: - 0.01, 0.09), 0.02 (95%CrI: - 0.03, 0.07), and 0.03 (95%CrI: - 0.001, 0.06) nmol/L increase in T3 concentrations, respectively. PFOA, PFNA, and PFDA were the predominant compounds in PFASs-FT3 associations, and the corresponding estimates were 0.11 (95% CrI: 0.02, 0.19), - 0.17 (95% CrI: - 0.28, - 0.07), and 0.12 (95% CrI: - 0.004, 0.24) pmol/L, respectively. A change in PFNA and PFOA concentrations from the 25th to 75th percentile was associated with a - 1.69 (95% CrI: - 2.98, - 0.41) μIU/mL decrease and a 1.51 (95% CrI: 0.48, 2.55) μIU/mL increase in TSH concentrations. The associations of PFOA and PFNA with T3/FT3 were more pronounced in boys, while those with TSH were more pronounced in girls.

CONCLUSION

Our results suggest that prenatal exposure to multiple PFASs was associated with thyroid hormones in cord blood. However, individual PFAS had varied effects-differing in magnitude and direction-on fetal thyroid hormones.

Authors+Show Affiliations

Department of Social Medicine and Reproductive Epidemiology, National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, #779 Lao Hu Min Road, Shanghai, 200032, China.Department of Social Medicine and Reproductive Epidemiology, National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, #779 Lao Hu Min Road, Shanghai, 200032, China.Department of Social Medicine and Reproductive Epidemiology, National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, #779 Lao Hu Min Road, Shanghai, 200032, China.National Management Office of Neonatal Screening Project for CHD, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.National Reference Laboratory of Dioxin, Institute of Health Inspection and Detection, Hubei Provincial Academy of Preventive Medicine, Hubei Provincial Center for Disease Control and Prevention, #6 Zhuo Daoquan North Road, Wuhan, 430079, China.National Reference Laboratory of Dioxin, Institute of Health Inspection and Detection, Hubei Provincial Academy of Preventive Medicine, Hubei Provincial Center for Disease Control and Prevention, #6 Zhuo Daoquan North Road, Wuhan, 430079, China.Department of Social Medicine and Reproductive Epidemiology, National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, #779 Lao Hu Min Road, Shanghai, 200032, China.Department of Social Medicine and Reproductive Epidemiology, National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, #779 Lao Hu Min Road, Shanghai, 200032, China.Department of Social Medicine and Reproductive Epidemiology, National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, #779 Lao Hu Min Road, Shanghai, 200032, China. yuanwei11@yahoo.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33243245

Citation

Liang, Hong, et al. "Prenatal Exposure to Perfluoroalkyl Substances and Thyroid Hormone Concentrations in Cord Plasma in a Chinese Birth Cohort." Environmental Health : a Global Access Science Source, vol. 19, no. 1, 2020, p. 127.
Liang H, Wang Z, Miao M, et al. Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort. Environ Health. 2020;19(1):127.
Liang, H., Wang, Z., Miao, M., Tian, Y., Zhou, Y., Wen, S., Chen, Y., Sun, X., & Yuan, W. (2020). Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort. Environmental Health : a Global Access Science Source, 19(1), 127. https://doi.org/10.1186/s12940-020-00679-7
Liang H, et al. Prenatal Exposure to Perfluoroalkyl Substances and Thyroid Hormone Concentrations in Cord Plasma in a Chinese Birth Cohort. Environ Health. 2020 11 26;19(1):127. PubMed PMID: 33243245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort. AU - Liang,Hong, AU - Wang,Ziliang, AU - Miao,Maohua, AU - Tian,Youping, AU - Zhou,Yan, AU - Wen,Sheng, AU - Chen,Yao, AU - Sun,Xiaowei, AU - Yuan,Wei, Y1 - 2020/11/26/ PY - 2020/08/07/received PY - 2020/11/13/accepted PY - 2020/11/27/entrez PY - 2020/11/28/pubmed PY - 2021/2/18/medline KW - Bayesian kernel machine regression KW - Cord blood KW - Perfluoroalkyl substances KW - Prenatal exposure KW - Prospective cohort study KW - Thyroid hormones SP - 127 EP - 127 JF - Environmental health : a global access science source JO - Environ Health VL - 19 IS - 1 N2 - BACKGROUND: Evidence of associations between prenatal exposure to perfluoroalkyl substances (PFASs) and fetal thyroid hormones (THs) is controversial, and few studies have estimated the associations, while addressing the high correlations among multiple PFASs. We aimed to examine the associations between prenatal PFAS exposure and thyroid hormone concentrations in cord blood. METHODS: A total of 300 mother-infant pairs from the Shanghai-Minhang Birth Cohort Study were included. We measured the concentrations of eight PFASs in maternal plasma samples collected at 12-16 gestational weeks, as well as those of total thyroxine (T4), free T4 (FT4), total triiodothyronine (T3), free T3 (FT3), and thyroid stimulating hormone (TSH) in cord plasma. We estimated the associations between maternal PFAS concentrations and TH concentrations using linear regression and Bayesian kernel machine regression (BKMR) models. RESULTS: In BKMR models, higher PFAS mixture concentrations were associated with increased T3 concentrations, and there were suggestive associations with increased FT3 concentrations. For single-exposure effects in BKMR models, a change in PFDA, PFUdA, and PFOA concentrations from the 25th to 75th percentile was associated with a 0.04 (95%CrI: - 0.01, 0.09), 0.02 (95%CrI: - 0.03, 0.07), and 0.03 (95%CrI: - 0.001, 0.06) nmol/L increase in T3 concentrations, respectively. PFOA, PFNA, and PFDA were the predominant compounds in PFASs-FT3 associations, and the corresponding estimates were 0.11 (95% CrI: 0.02, 0.19), - 0.17 (95% CrI: - 0.28, - 0.07), and 0.12 (95% CrI: - 0.004, 0.24) pmol/L, respectively. A change in PFNA and PFOA concentrations from the 25th to 75th percentile was associated with a - 1.69 (95% CrI: - 2.98, - 0.41) μIU/mL decrease and a 1.51 (95% CrI: 0.48, 2.55) μIU/mL increase in TSH concentrations. The associations of PFOA and PFNA with T3/FT3 were more pronounced in boys, while those with TSH were more pronounced in girls. CONCLUSION: Our results suggest that prenatal exposure to multiple PFASs was associated with thyroid hormones in cord blood. However, individual PFAS had varied effects-differing in magnitude and direction-on fetal thyroid hormones. SN - 1476-069X UR - https://www.unboundmedicine.com/medline/citation/33243245/Prenatal_exposure_to_perfluoroalkyl_substances_and_thyroid_hormone_concentrations_in_cord_plasma_in_a_Chinese_birth_cohort_ L2 - https://ehjournal.biomedcentral.com/articles/10.1186/s12940-020-00679-7 DB - PRIME DP - Unbound Medicine ER -