Tags

Type your tag names separated by a space and hit enter

Cronkhite-Canada Syndrome Successfully Treated by Corticosteroids before Presenting Typical Ectodermal Symptoms.
Case Rep Gastroenterol. 2020 Sep-Dec; 14(3):561-569.CR

Abstract

Cronkhite-Canada syndrome (CCS) is a rare disease characterized by diffuse gastrointestinal polyposis with chronic diarrhea and ectodermal change, but its etiology is unknown. We present a case at the age of 26 years complaining of epigastralgia and weight loss. Endoscopic examination revealed extensive diffuse polypoid lesions of the stomach and the terminal ileum, all of which showed hyperplastic polyps pathologically. There were no polypoid lesions in his colon. He has no family history of diffuse gastrointestinal polyposis. Diffuse gastrointestinal hyperplastic polyposis without any hereditary association led us to suspect this case as CCS although he did not show chronic diarrhea and any ectodermal symptoms such as onychodystrophy, alopecia, and hyperpigmentation. After initiation of a corticosteroid therapy, his epigastralgia disappeared and he gained appetite and weight, accompanied by normalization of serum albumin levels. Endoscopic examination 1 year after initiation of corticosteroid therapy revealed a decrease in the number of gastric polyposis and those inflammations. This rare young case may suggest that early therapeutic intervention with corticosteroids could improve the prognosis of CCS, preventing not only malnutrition but also appearance of several ectodermal symptoms.

Authors+Show Affiliations

Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Shimotsuke, Japan. Department of Gastroenterology, International University of Health and Welfare, Nasushiobara, Japan.Department of Gastroenterology, International University of Health and Welfare, Nasushiobara, Japan.Department of Pathology, International University of Health and Welfare, Nasushiobara, Japan.Department of Gastroenterology, International University of Health and Welfare, Nasushiobara, Japan.Department of Gastroenterology, International University of Health and Welfare, Nasushiobara, Japan.Department of Gastroenterology, International University of Health and Welfare, Nasushiobara, Japan.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

33250698

Citation

Murata, Kazumoto, et al. "Cronkhite-Canada Syndrome Successfully Treated By Corticosteroids Before Presenting Typical Ectodermal Symptoms." Case Reports in Gastroenterology, vol. 14, no. 3, 2020, pp. 561-569.
Murata K, Sato K, Okada S, et al. Cronkhite-Canada Syndrome Successfully Treated by Corticosteroids before Presenting Typical Ectodermal Symptoms. Case Rep Gastroenterol. 2020;14(3):561-569.
Murata, K., Sato, K., Okada, S., Suto, D., Otake, T., & Kohgo, Y. (2020). Cronkhite-Canada Syndrome Successfully Treated by Corticosteroids before Presenting Typical Ectodermal Symptoms. Case Reports in Gastroenterology, 14(3), 561-569. https://doi.org/10.1159/000510920
Murata K, et al. Cronkhite-Canada Syndrome Successfully Treated By Corticosteroids Before Presenting Typical Ectodermal Symptoms. Case Rep Gastroenterol. 2020 Sep-Dec;14(3):561-569. PubMed PMID: 33250698.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cronkhite-Canada Syndrome Successfully Treated by Corticosteroids before Presenting Typical Ectodermal Symptoms. AU - Murata,Kazumoto, AU - Sato,Kiichi, AU - Okada,Shinya, AU - Suto,Daisuke, AU - Otake,Takaaki, AU - Kohgo,Yutaka, Y1 - 2020/10/30/ PY - 2020/07/30/received PY - 2020/08/12/accepted PY - 2020/11/30/entrez PY - 2020/12/1/pubmed PY - 2020/12/1/medline KW - Corticosteroids KW - Cronkhite-Canada syndrome KW - Nonhereditary polyposis KW - Remission SP - 561 EP - 569 JF - Case reports in gastroenterology JO - Case Rep Gastroenterol VL - 14 IS - 3 N2 - Cronkhite-Canada syndrome (CCS) is a rare disease characterized by diffuse gastrointestinal polyposis with chronic diarrhea and ectodermal change, but its etiology is unknown. We present a case at the age of 26 years complaining of epigastralgia and weight loss. Endoscopic examination revealed extensive diffuse polypoid lesions of the stomach and the terminal ileum, all of which showed hyperplastic polyps pathologically. There were no polypoid lesions in his colon. He has no family history of diffuse gastrointestinal polyposis. Diffuse gastrointestinal hyperplastic polyposis without any hereditary association led us to suspect this case as CCS although he did not show chronic diarrhea and any ectodermal symptoms such as onychodystrophy, alopecia, and hyperpigmentation. After initiation of a corticosteroid therapy, his epigastralgia disappeared and he gained appetite and weight, accompanied by normalization of serum albumin levels. Endoscopic examination 1 year after initiation of corticosteroid therapy revealed a decrease in the number of gastric polyposis and those inflammations. This rare young case may suggest that early therapeutic intervention with corticosteroids could improve the prognosis of CCS, preventing not only malnutrition but also appearance of several ectodermal symptoms. SN - 1662-0631 UR - https://www.unboundmedicine.com/medline/citation/33250698/Cronkhite_Canada_Syndrome_Successfully_Treated_by_Corticosteroids_before_Presenting_Typical_Ectodermal_Symptoms_ L2 - https://www.karger.com?DOI=10.1159/000510920 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.