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Gastric secretion and emptying after ordinary meals in duodenal ulcer.
Gastroenterology. 1977 Nov; 73(5):989-94.G

Abstract

We have studied the gastric response to an ordinary solid-liquid meal in 12 patients with active duodenal ulcer and 8 healthy volunteers. Our method employs gastric and duodenal markers to quantify acid, pepsin, and volume outputs in response to the meal, without manipulating intragastric pH. Intragastric volume, rate of gastric emptying, delivery of acid into the duodenum, and serum gastrin response were also measured simultaneously. On a separate day, peak acid output in response to betazole (1.5 mg per kg subcutaneously) was determined. Our results indicate an inappropriately prolonged gastric secretory response to meals in duodenal ulcer disease, without a concomitant increase in peak postprandial secretory rates or an increase in serum immunoreactive gastrin levels. Further, the stomach in duodenal ulcer disease did not "retain" the additional acid secreted in the later postprandial period, and abnormally high rates of acid delivery into the duodenum occurred. Our data are consistent with a dual defect in the duodenal mechanisms regulating both acid secretion and acid delivery into the duodenum.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

332582

Citation

Malagelada, J R., et al. "Gastric Secretion and Emptying After Ordinary Meals in Duodenal Ulcer." Gastroenterology, vol. 73, no. 5, 1977, pp. 989-94.
Malagelada JR, Longstreth GF, Deering TB, et al. Gastric secretion and emptying after ordinary meals in duodenal ulcer. Gastroenterology. 1977;73(5):989-94.
Malagelada, J. R., Longstreth, G. F., Deering, T. B., Summerskill, W. H., & Go, V. L. (1977). Gastric secretion and emptying after ordinary meals in duodenal ulcer. Gastroenterology, 73(5), 989-94.
Malagelada JR, et al. Gastric Secretion and Emptying After Ordinary Meals in Duodenal Ulcer. Gastroenterology. 1977;73(5):989-94. PubMed PMID: 332582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric secretion and emptying after ordinary meals in duodenal ulcer. AU - Malagelada,J R, AU - Longstreth,G F, AU - Deering,T B, AU - Summerskill,W H, AU - Go,V L, PY - 1977/11/1/pubmed PY - 1977/11/1/medline PY - 1977/11/1/entrez SP - 989 EP - 94 JF - Gastroenterology JO - Gastroenterology VL - 73 IS - 5 N2 - We have studied the gastric response to an ordinary solid-liquid meal in 12 patients with active duodenal ulcer and 8 healthy volunteers. Our method employs gastric and duodenal markers to quantify acid, pepsin, and volume outputs in response to the meal, without manipulating intragastric pH. Intragastric volume, rate of gastric emptying, delivery of acid into the duodenum, and serum gastrin response were also measured simultaneously. On a separate day, peak acid output in response to betazole (1.5 mg per kg subcutaneously) was determined. Our results indicate an inappropriately prolonged gastric secretory response to meals in duodenal ulcer disease, without a concomitant increase in peak postprandial secretory rates or an increase in serum immunoreactive gastrin levels. Further, the stomach in duodenal ulcer disease did not "retain" the additional acid secreted in the later postprandial period, and abnormally high rates of acid delivery into the duodenum occurred. Our data are consistent with a dual defect in the duodenal mechanisms regulating both acid secretion and acid delivery into the duodenum. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/332582/Gastric_secretion_and_emptying_after_ordinary_meals_in_duodenal_ulcer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016508577003059 DB - PRIME DP - Unbound Medicine ER -