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Maternal and perinatal characteristics and outcomes of pregnancies complicated with COVID-19 in Kuwait.
BMC Pregnancy Childbirth. 2020 Dec 02; 20(1):754.BP

Abstract

BACKGROUND

The effect of SARS-CoV-2 infection in pregnant women and newborns is incompletely understood. Preliminary data shows a rather fluctuating course of the disease from asymptomatic or mild symptoms to maternal death. However, it is not clear whether the disease increases the risk of pregnancy-related complications. The aim of the study is to describe the maternal and neonatal clinical characteristics and outcome of pregnancies with SARS-CoV-2 infection.

METHODS

In this retrospective national-based study, we analyzed the medical records of all pregnant women infected with SARS-CoV-2 and their neonates who were admitted to New-Jahra Hospital (NJH), Kuwait, between March 15th 2020 and May 31st 2020. During the study period and as part of the public health measures, a total of 185 pregnant women infected with SARS-CoV-2, regardless of symptoms, were hospitalized at NJH, and were included. Maternal and neonatal clinical manifestations, laboratory tests and treatments were collected. The outcomes of pregnancies included miscarriage, intrauterine fetal death (IUFD), preterm birth and live birth were assessed until the end date of the outcomes follow-up (November 10th 2020).

RESULTS

A total of 185 pregnant women infected with SARS-CoV-2 were enrolled with a median age of 31 years (interquartile range, IQR: 27.5-34), and median gestational age at diagnosis of SARS-CoV2 infection was 29 weeks (IQR: 18-34). The majority (88%) of these women had mild symptoms, with fever (58%) being the most common presenting symptom followed by cough (50.6%). At the time of the analysis, out of the 185, 3 (1.6%) of the pregnant women had a miscarriage, 1 (0.54%) had IUFD which was not related to COVID-19, 16 (8.6%) had ongoing pregnancies and 165 (89%) had a live birth. Only 2 (1.1%) of these women developed severe pneumonia and required intensive care. A total of 167 neonates with two sets of twins were born with median gestational age at birth was 38 (IQR: 36-39) weeks. Most of the neonates were asymptomatic, and only 2 of them tested positive on day 5 by nasopharyngeal swab testing.

CONCLUSIONS

In this national-based study, most of the pregnant women infected with SARS-CoV-2 showed mild symptoms. Although mother-to-child vertical transmission of SARS-CoV-2 is possible, COVID-19 infection during pregnancy may not lead to unfavorable maternal and neonatal outcomes.

Authors+Show Affiliations

Obstetrics and Gynecology Department, Farwaniya Hospital, Sabah Al Nasser, Kuwait.Paediatric Department, Farwaniya Hospital, Sabah Al Nasser, Kuwait.Obstetrics and Gynecology Department, Farwaniya Hospital, Sabah Al Nasser, Kuwait.Department of Microbiology, Faculty of Medicine, Kuwait University, Jabriya, Kuwait.Paediatrics Department, Faculty of Medicine, Kuwait University, Jabriya, Kuwait.Neonatal Department, Maternity Hospital, Kuwait City, Kuwait.Obstetrics and Gynaecology Department, Al-Adan Hospital, Hadiya, Kuwait.Obstetrics and Gynecology Department, Farwaniya Hospital, Sabah Al Nasser, Kuwait.Neonatal Department, Farwaniya Hospital, Subah An Nasser, 81400, Kuwait City, Kuwait. mariam.ayed@hsc.edu.kw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33267785

Citation

Ayed, Amal, et al. "Maternal and Perinatal Characteristics and Outcomes of Pregnancies Complicated With COVID-19 in Kuwait." BMC Pregnancy and Childbirth, vol. 20, no. 1, 2020, p. 754.
Ayed A, Embaireeg A, Benawadh A, et al. Maternal and perinatal characteristics and outcomes of pregnancies complicated with COVID-19 in Kuwait. BMC Pregnancy Childbirth. 2020;20(1):754.
Ayed, A., Embaireeg, A., Benawadh, A., Al-Fouzan, W., Hammoud, M., Al-Hathal, M., Alzaydai, A., Ahmad, A., & Ayed, M. (2020). Maternal and perinatal characteristics and outcomes of pregnancies complicated with COVID-19 in Kuwait. BMC Pregnancy and Childbirth, 20(1), 754. https://doi.org/10.1186/s12884-020-03461-2
Ayed A, et al. Maternal and Perinatal Characteristics and Outcomes of Pregnancies Complicated With COVID-19 in Kuwait. BMC Pregnancy Childbirth. 2020 Dec 2;20(1):754. PubMed PMID: 33267785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal and perinatal characteristics and outcomes of pregnancies complicated with COVID-19 in Kuwait. AU - Ayed,Amal, AU - Embaireeg,Alia, AU - Benawadh,Asmaa, AU - Al-Fouzan,Wadha, AU - Hammoud,Majdeda, AU - Al-Hathal,Monif, AU - Alzaydai,Abeer, AU - Ahmad,Ashraf, AU - Ayed,Mariam, Y1 - 2020/12/02/ PY - 2020/08/11/received PY - 2020/11/26/accepted PY - 2020/12/3/entrez PY - 2020/12/4/pubmed PY - 2020/12/4/medline KW - COVID-19 KW - Clinical features KW - Neonates KW - Pregnant women KW - SARS-CoV-2 SP - 754 EP - 754 JF - BMC pregnancy and childbirth JO - BMC Pregnancy Childbirth VL - 20 IS - 1 N2 - BACKGROUND: The effect of SARS-CoV-2 infection in pregnant women and newborns is incompletely understood. Preliminary data shows a rather fluctuating course of the disease from asymptomatic or mild symptoms to maternal death. However, it is not clear whether the disease increases the risk of pregnancy-related complications. The aim of the study is to describe the maternal and neonatal clinical characteristics and outcome of pregnancies with SARS-CoV-2 infection. METHODS: In this retrospective national-based study, we analyzed the medical records of all pregnant women infected with SARS-CoV-2 and their neonates who were admitted to New-Jahra Hospital (NJH), Kuwait, between March 15th 2020 and May 31st 2020. During the study period and as part of the public health measures, a total of 185 pregnant women infected with SARS-CoV-2, regardless of symptoms, were hospitalized at NJH, and were included. Maternal and neonatal clinical manifestations, laboratory tests and treatments were collected. The outcomes of pregnancies included miscarriage, intrauterine fetal death (IUFD), preterm birth and live birth were assessed until the end date of the outcomes follow-up (November 10th 2020). RESULTS: A total of 185 pregnant women infected with SARS-CoV-2 were enrolled with a median age of 31 years (interquartile range, IQR: 27.5-34), and median gestational age at diagnosis of SARS-CoV2 infection was 29 weeks (IQR: 18-34). The majority (88%) of these women had mild symptoms, with fever (58%) being the most common presenting symptom followed by cough (50.6%). At the time of the analysis, out of the 185, 3 (1.6%) of the pregnant women had a miscarriage, 1 (0.54%) had IUFD which was not related to COVID-19, 16 (8.6%) had ongoing pregnancies and 165 (89%) had a live birth. Only 2 (1.1%) of these women developed severe pneumonia and required intensive care. A total of 167 neonates with two sets of twins were born with median gestational age at birth was 38 (IQR: 36-39) weeks. Most of the neonates were asymptomatic, and only 2 of them tested positive on day 5 by nasopharyngeal swab testing. CONCLUSIONS: In this national-based study, most of the pregnant women infected with SARS-CoV-2 showed mild symptoms. Although mother-to-child vertical transmission of SARS-CoV-2 is possible, COVID-19 infection during pregnancy may not lead to unfavorable maternal and neonatal outcomes. SN - 1471-2393 UR - https://www.unboundmedicine.com/medline/citation/33267785/Maternal_and_perinatal_characteristics_and_outcomes_of_pregnancies_complicated_with_COVID_19_in_Kuwait_ L2 - https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-020-03461-2 DB - PRIME DP - Unbound Medicine ER -