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Epidemiological and clinical characteristics of fifty-six cases of COVID-19 in Liaoning Province, China.
World J Clin Cases. 2020 Nov 06; 8(21):5188-5202.WJ

Abstract

BACKGROUND

Pneumonia of uncertain cause has been reported in Wuhan, China since the beginning of early December 2019. In early January 2020, a novel strain of β-coronavirus was identified by the Chinese Center for Disease Control and Prevention from the pharyngeal swab specimens of patients, which was recently named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There is evidence of human-to-human transmission and familial cluster outbreak of SARS-CoV-2 infection. The World Health Organization(WHO) recently declared the SARS-CoV-2 epidemic a global health emergency. As of February 17, 2020, 71329 laboratory-confirmed cases (in 25 countries, including the United States and Germany) have been reported globally. Other than its rapid transmission, the epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19) remain unclear. In December 2019, coronavirus disease (named COVID-19 by the WHO) associated with the SARS-CoV-2 emerged in Wuhan, China and spread quickly across the country.

AIM

To analyze the epidemiological and clinical characteristics of confirmed cases of this disease in Liaoning province, a Chinese region about 1800 km north of Wuhan.

METHODS

The clinical data of 56 laboratory-confirmed COVID-19 cases due to 2019-nCoV infection were analyzed. The cases originated from eight cities in Liaoning province.

RESULTS

The median age of the patients was 45 years, and 57.1% of them were male. No patient had been in direct contact with wild animals. Among them, 23 patients (41.1%) had resided in or traveled to Wuhan, 27 cases (48.2%) had been in contact with confirmed COVID-19 patients, 5 cases (8.9%) had been in contact with confirmed patients with a contact history to COVID-19 patients, and 1 case (1.8%) had no apparent history of exposure. Fever (75.0%) and cough (60.7%) were the most common symptoms. The typical manifestations in lung computed tomography (CT) included ground-glass opacity and patchy shadows, with 67.8% of them being bilateral. Among the patients in the cohort, 78.6% showed reduction in their lymphocyte counts, 57.1% showed increases in their C-reactive protein levels, and 50.0% showed decreases in their blood albumin levels. Eleven patients (19.6%) were admitted to intensive care unit, 2 patients (3.5%) progressed to acute respiratory distress syndrome, 4 patients (7.1%) were equipped with non-invasive mechanical ventilation, and 1 patient (1.8) received extracorporeal membrane oxygenation support. There were 5 mild cases (5/56, 8.9%), 40 moderate cases (40/56, 71.4%), 10 severe cases (10/56, 17.9%), and 1 critical case (1/56, 1.8%). No deaths were reported.

CONCLUSION

SARS-CoV-2 can be transmitted among humans. Most COVID-19 patients show symptoms of fever, cough, lymphocyte reduction, and typical lung CT manifestations. Most are moderate cases. The seriousness of the disease (as indicated by blood oxygen saturation, respiratory rate, oxygenation index, blood lymphocyte count, and lesions shown in lung CT) is related to history of living in or traveling to Wuhan, underlying diseases, admittance to intensive care unit, and mechanical ventilation.

Authors+Show Affiliations

Department of Infectious Disease, The Sixth People's Hospital of Shenyang, Shenyang 110006, Liaoning Province, China.Department of General Surgery, The Second Affiliated Hospital of Shenyang Medical College, Shenyang 110002, Liaoning Province, China.Department of Infectious Disease, The Sixth People's Hospital of Shenyang, Shenyang 110006, Liaoning Province, China.Department of Clinical Laboratory, The Sixth People's Hospital of Shenyang, Shenyang 110006, Liaoning Province, China.Department of Infectious Disease, The Sixth People's Hospital of Shenyang, Shenyang 110006, Liaoning Province, China.Department of Infectious Disease, The Sixth People's Hospital of Shenyang, Shenyang 110006, Liaoning Province, China.Department of Infectious Disease, The Sixth People's Hospital of Shenyang, Shenyang 110006, Liaoning Province, China.Department of Intensive Critical Medicine, The Sixth People's Hospital of Shenyang, Shenyang 110006, Liaoning Province, China.Department of Infectious Disease, The Sixth People's Hospital of Shenyang, Shenyang 110006, Liaoning Province, China.Department of Infectious Disease, The Sixth People's Hospital of Shenyang, Shenyang 110006, Liaoning Province, China.Department of Infectious Disease, The Sixth People's Hospital of Shenyang, Shenyang 110006, Liaoning Province, China.Department of Infectious Disease, The Sixth People's Hospital of Shenyang, Shenyang 110006, Liaoning Province, China.Department of Infectious Diseases Clinic, The Sixth People's Hospital of Shenyang, Shenyang 110006, Liaoning Province, China.Department of Infectious Disease, The Sixth People's Hospital of Shenyang, Shenyang 110006, Liaoning Province, China.Department of Infectious Disease, The Sixth People's Hospital of Shenyang, Shenyang 110006, Liaoning Province, China.Department of Infectious Diseases Clinic, The Sixth People's Hospital of Shenyang, Shenyang 110006, Liaoning Province, China.Department of Infectious Disease, The Sixth People's Hospital of Shenyang, Shenyang 110006, Liaoning Province, China.Department of Infectious Disease, The Sixth People's Hospital of Shenyang, Shenyang 110006, Liaoning Province, China. gu3311@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33269255

Citation

Wang, Jing-Bo, et al. "Epidemiological and Clinical Characteristics of Fifty-six Cases of COVID-19 in Liaoning Province, China." World Journal of Clinical Cases, vol. 8, no. 21, 2020, pp. 5188-5202.
Wang JB, Wang HT, Wang LS, et al. Epidemiological and clinical characteristics of fifty-six cases of COVID-19 in Liaoning Province, China. World J Clin Cases. 2020;8(21):5188-5202.
Wang, J. B., Wang, H. T., Wang, L. S., Li, L. P., Xv, J., Xv, C., Li, X. H., Wu, Y. H., Liu, H. Y., Li, B. J., Yu, H., Tian, X., Zhang, Z. Y., Wang, Y., Zhao, R., Liu, J. Y., Wang, W., & Gu, Y. (2020). Epidemiological and clinical characteristics of fifty-six cases of COVID-19 in Liaoning Province, China. World Journal of Clinical Cases, 8(21), 5188-5202. https://doi.org/10.12998/wjcc.v8.i21.5188
Wang JB, et al. Epidemiological and Clinical Characteristics of Fifty-six Cases of COVID-19 in Liaoning Province, China. World J Clin Cases. 2020 Nov 6;8(21):5188-5202. PubMed PMID: 33269255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiological and clinical characteristics of fifty-six cases of COVID-19 in Liaoning Province, China. AU - Wang,Jing-Bo, AU - Wang,Hai-Tao, AU - Wang,Lei-Shi, AU - Li,Lu-Ping, AU - Xv,Jiao, AU - Xv,Chun, AU - Li,Xing-Hai, AU - Wu,Yun-Hai, AU - Liu,Hong-Yan, AU - Li,Bai-Jun, AU - Yu,Hong, AU - Tian,Xia, AU - Zhang,Zhi-Yu, AU - Wang,Yan, AU - Zhao,Rui, AU - Liu,Jin-Yang, AU - Wang,Wei, AU - Gu,Ye, PY - 2020/05/12/received PY - 2020/08/31/revised PY - 2020/09/22/accepted PY - 2020/12/3/entrez PY - 2020/12/4/pubmed PY - 2020/12/4/medline KW - Acute respiratory distress syndrome KW - COVID-19 KW - Clinical characteristics KW - Epidemiological characteristics KW - Hypoxemia KW - SARS-CoV-2 SP - 5188 EP - 5202 JF - World journal of clinical cases JO - World J Clin Cases VL - 8 IS - 21 N2 - BACKGROUND: Pneumonia of uncertain cause has been reported in Wuhan, China since the beginning of early December 2019. In early January 2020, a novel strain of β-coronavirus was identified by the Chinese Center for Disease Control and Prevention from the pharyngeal swab specimens of patients, which was recently named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There is evidence of human-to-human transmission and familial cluster outbreak of SARS-CoV-2 infection. The World Health Organization(WHO) recently declared the SARS-CoV-2 epidemic a global health emergency. As of February 17, 2020, 71329 laboratory-confirmed cases (in 25 countries, including the United States and Germany) have been reported globally. Other than its rapid transmission, the epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19) remain unclear. In December 2019, coronavirus disease (named COVID-19 by the WHO) associated with the SARS-CoV-2 emerged in Wuhan, China and spread quickly across the country. AIM: To analyze the epidemiological and clinical characteristics of confirmed cases of this disease in Liaoning province, a Chinese region about 1800 km north of Wuhan. METHODS: The clinical data of 56 laboratory-confirmed COVID-19 cases due to 2019-nCoV infection were analyzed. The cases originated from eight cities in Liaoning province. RESULTS: The median age of the patients was 45 years, and 57.1% of them were male. No patient had been in direct contact with wild animals. Among them, 23 patients (41.1%) had resided in or traveled to Wuhan, 27 cases (48.2%) had been in contact with confirmed COVID-19 patients, 5 cases (8.9%) had been in contact with confirmed patients with a contact history to COVID-19 patients, and 1 case (1.8%) had no apparent history of exposure. Fever (75.0%) and cough (60.7%) were the most common symptoms. The typical manifestations in lung computed tomography (CT) included ground-glass opacity and patchy shadows, with 67.8% of them being bilateral. Among the patients in the cohort, 78.6% showed reduction in their lymphocyte counts, 57.1% showed increases in their C-reactive protein levels, and 50.0% showed decreases in their blood albumin levels. Eleven patients (19.6%) were admitted to intensive care unit, 2 patients (3.5%) progressed to acute respiratory distress syndrome, 4 patients (7.1%) were equipped with non-invasive mechanical ventilation, and 1 patient (1.8) received extracorporeal membrane oxygenation support. There were 5 mild cases (5/56, 8.9%), 40 moderate cases (40/56, 71.4%), 10 severe cases (10/56, 17.9%), and 1 critical case (1/56, 1.8%). No deaths were reported. CONCLUSION: SARS-CoV-2 can be transmitted among humans. Most COVID-19 patients show symptoms of fever, cough, lymphocyte reduction, and typical lung CT manifestations. Most are moderate cases. The seriousness of the disease (as indicated by blood oxygen saturation, respiratory rate, oxygenation index, blood lymphocyte count, and lesions shown in lung CT) is related to history of living in or traveling to Wuhan, underlying diseases, admittance to intensive care unit, and mechanical ventilation. SN - 2307-8960 UR - https://www.unboundmedicine.com/medline/citation/33269255/Epidemiological_and_clinical_characteristics_of_fifty_six_cases_of_COVID_19_in_Liaoning_Province_China_ L2 - https://www.wjgnet.com/2307-8960/full/v8/i21/5188.htm DB - PRIME DP - Unbound Medicine ER -
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