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Vector competence of Aedes aegypti from Havana, Cuba, for dengue virus type 1, chikungunya, and Zika viruses.
PLoS Negl Trop Dis. 2020 12; 14(12):e0008941.PN

Abstract

BACKGROUND

Like many countries from the Americas, Cuba is threatened by Aedes aegypti-associated arboviruses such as dengue (DENV), Zika (ZIKV), and chikungunya (CHIKV) viruses. Curiously, when CHIKV was actively circulating in the region in 2013-2014, no autochthonous transmission of this virus was detected in Havana, Cuba, despite the importation of chikungunya cases into this city. To investigate if the transmission ability of local mosquito populations could explain this epidemiological scenario, we evaluated for the first time the vector competence of two Ae. aegypti populations (Pasteur and Párraga) collected from Havana for dengue virus type 1 (DENV-1), CHIKV, and ZIKV.

METHODOLOGY/PRINCIPAL FINDINGS

Mosquito populations were fed separately using blood containing ZIKV, DENV-1, or CHIKV. Infection, dissemination, and transmission rates, were estimated at 3 (exclusively for CHIKV), 7, and 14 days post exposure (dpe) for each Ae. aegypti population-virus combination. Both mosquito populations were susceptible to DENV-1 and ZIKV, with viral infection and dissemination rates ranging from 24-97% and 6-67% respectively. In addition, CHIKV disseminated in both populations and was subsequently transmitted. Transmission rates were low (<30%) regardless of the mosquito population/virus combination and no ZIKV was detected in saliva of females from the Pasteur population at any dpe.

CONCLUSIONS/SIGNIFICANCE

Our study demonstrated the ability of Ae. aegypti from Cuba to transmit DENV, ZIKV, and CHIKV. These results, along with the widespread distribution and high abundance of this species in the urban settings throughout the island, highlight the importance of Ae. aegypti control and arbovirus surveillance to prevent future outbreaks.

Authors+Show Affiliations

Department of Vector Control, Center for Research, Diagnostic, and Reference, Institute of Tropical Medicine Pedro Kourí, PAHO-WHO Collaborating Center for Dengue and its Control, Havana, Cuba.Institut Pasteur of Guadeloupe, Laboratory of Vector Control research, Unit Transmission Reservoir and Pathogens Diversity, Les Abymes, France.Department of Vector Control, Center for Research, Diagnostic, and Reference, Institute of Tropical Medicine Pedro Kourí, PAHO-WHO Collaborating Center for Dengue and its Control, Havana, Cuba.Institut Pasteur of Guadeloupe, Laboratory of Vector Control research, Unit Transmission Reservoir and Pathogens Diversity, Les Abymes, France.Department of Vector Control, Center for Research, Diagnostic, and Reference, Institute of Tropical Medicine Pedro Kourí, PAHO-WHO Collaborating Center for Dengue and its Control, Havana, Cuba.Department of Vector Control, Center for Research, Diagnostic, and Reference, Institute of Tropical Medicine Pedro Kourí, PAHO-WHO Collaborating Center for Dengue and its Control, Havana, Cuba.Institut Pasteur of Guadeloupe, Laboratory of Vector Control research, Unit Transmission Reservoir and Pathogens Diversity, Les Abymes, France.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33270652

Citation

Gutiérrez-Bugallo, Gladys, et al. "Vector Competence of Aedes Aegypti From Havana, Cuba, for Dengue Virus Type 1, Chikungunya, and Zika Viruses." PLoS Neglected Tropical Diseases, vol. 14, no. 12, 2020, pp. e0008941.
Gutiérrez-Bugallo G, Boullis A, Martinez Y, et al. Vector competence of Aedes aegypti from Havana, Cuba, for dengue virus type 1, chikungunya, and Zika viruses. PLoS Negl Trop Dis. 2020;14(12):e0008941.
Gutiérrez-Bugallo, G., Boullis, A., Martinez, Y., Hery, L., Rodríguez, M., Bisset, J. A., & Vega-Rúa, A. (2020). Vector competence of Aedes aegypti from Havana, Cuba, for dengue virus type 1, chikungunya, and Zika viruses. PLoS Neglected Tropical Diseases, 14(12), e0008941. https://doi.org/10.1371/journal.pntd.0008941
Gutiérrez-Bugallo G, et al. Vector Competence of Aedes Aegypti From Havana, Cuba, for Dengue Virus Type 1, Chikungunya, and Zika Viruses. PLoS Negl Trop Dis. 2020;14(12):e0008941. PubMed PMID: 33270652.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vector competence of Aedes aegypti from Havana, Cuba, for dengue virus type 1, chikungunya, and Zika viruses. AU - Gutiérrez-Bugallo,Gladys, AU - Boullis,Antoine, AU - Martinez,Yanet, AU - Hery,Lyza, AU - Rodríguez,Magdalena, AU - Bisset,Juan A, AU - Vega-Rúa,Anubis, Y1 - 2020/12/03/ PY - 2020/06/02/received PY - 2020/11/01/accepted PY - 2020/12/15/revised PY - 2020/12/4/pubmed PY - 2021/2/23/medline PY - 2020/12/3/entrez SP - e0008941 EP - e0008941 JF - PLoS neglected tropical diseases JO - PLoS Negl Trop Dis VL - 14 IS - 12 N2 - BACKGROUND: Like many countries from the Americas, Cuba is threatened by Aedes aegypti-associated arboviruses such as dengue (DENV), Zika (ZIKV), and chikungunya (CHIKV) viruses. Curiously, when CHIKV was actively circulating in the region in 2013-2014, no autochthonous transmission of this virus was detected in Havana, Cuba, despite the importation of chikungunya cases into this city. To investigate if the transmission ability of local mosquito populations could explain this epidemiological scenario, we evaluated for the first time the vector competence of two Ae. aegypti populations (Pasteur and Párraga) collected from Havana for dengue virus type 1 (DENV-1), CHIKV, and ZIKV. METHODOLOGY/PRINCIPAL FINDINGS: Mosquito populations were fed separately using blood containing ZIKV, DENV-1, or CHIKV. Infection, dissemination, and transmission rates, were estimated at 3 (exclusively for CHIKV), 7, and 14 days post exposure (dpe) for each Ae. aegypti population-virus combination. Both mosquito populations were susceptible to DENV-1 and ZIKV, with viral infection and dissemination rates ranging from 24-97% and 6-67% respectively. In addition, CHIKV disseminated in both populations and was subsequently transmitted. Transmission rates were low (<30%) regardless of the mosquito population/virus combination and no ZIKV was detected in saliva of females from the Pasteur population at any dpe. CONCLUSIONS/SIGNIFICANCE: Our study demonstrated the ability of Ae. aegypti from Cuba to transmit DENV, ZIKV, and CHIKV. These results, along with the widespread distribution and high abundance of this species in the urban settings throughout the island, highlight the importance of Ae. aegypti control and arbovirus surveillance to prevent future outbreaks. SN - 1935-2735 UR - https://www.unboundmedicine.com/medline/citation/33270652/Vector_competence_of_Aedes_aegypti_from_Havana_Cuba_for_dengue_virus_type_1_chikungunya_and_Zika_viruses_ L2 - https://dx.plos.org/10.1371/journal.pntd.0008941 DB - PRIME DP - Unbound Medicine ER -