TY - JOUR T1 - Review on Alzheimer's disease: Inhibition of amyloid beta and tau tangle formation. AU - Ashrafian,Hossein, AU - Zadeh,Elaheh Hadi, AU - Khan,Rizwan Hasan, Y1 - 2020/12/02/ PY - 2020/09/12/received PY - 2020/11/18/revised PY - 2020/11/28/accepted PY - 2020/12/6/pubmed PY - 2021/4/22/medline PY - 2020/12/5/entrez KW - Amyloid beta plaques KW - Amyloid precursor protein KW - Dementia KW - Neurofibrillary tangles SP - 382 EP - 394 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 167 N2 - It is reported that approximately 40 million people are suffering from dementia, globally. Dementia is a group of symptoms that affect neurons and cause some mental disorders, such as losing memory. Alzheimer's disease (AD) which is known as the most common cause of dementia, is one of the top medical care concerns across the world. Although the exact sources of the disease are not understood, is it believed that aggregation of amyloid-beta (Aβ) outside of neuron cells and tau aggregation or neurofibrillary tangles (NFTs) formation inside the cell may play crucial roles. In this paper, we are going to review studies that targeted inhibition of amyloid plaque and tau protein tangle formation, to suppress or postpone AD. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/33278431/Review_on_Alzheimer's_disease:_Inhibition_of_amyloid_beta_and_tau_tangle_formation_ DB - PRIME DP - Unbound Medicine ER -