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Effect of ibuprofen entrapment procedure on physicochemical and controlled drug release performances of chitosan/xanthan gum polyelectrolyte complexes.
Int J Biol Macromol. 2021 Jan 15; 167:547-558.IJ

Abstract

The effect of the entrapment procedure of a poorly water soluble drug (ibuprofen) on physicochemical and drug release performances of chitosan/xanthan polyelectrolyte complexes (PECs) was investigated to achieve controlled drug release as the ultimate goal. The formation of PECs for two drug entrapment procedures (before or after the mixing of polymers) at pH 4.6 and 5.6 and three chitosan-to-xanthan mass ratios (1:1, 1:2 and 1:3) was observed by continuous decrease in conductivity during the PECs formation and increased apparent viscosity and hysteresis values. The most extensive crosslinking was observed with ibuprofen added before the PECs formation at pH 4.6 and chitosan-to-xanthan mass ratio 1:1. The PECs prepared at polymers' mass ratios 1:2 and 1:3 had higher yield and drug entrapment efficiency. DSC and FT-IR analysis confirmed ibuprofen entrapment in PECs and the partial disruption of its crystallinity. All ibuprofen release profiles were similar, with 60-70% of drug released after 12 h, mainly by diffusion, but erosion and polymer chain relaxation were also included. Potentially optimal can be considered the PEC prepared at pH 4.6, ibuprofen entrapped before the mixing of polymers at chitosan-to-xanthan mass ratio 1:2, which provided controlled drug release by zero-order kinetics, high yield, and drug entrapment efficiency.

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Authors+Show Affiliations

Ćirić A
University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: ana.ciric@pharmacy.bg.ac.rs.
Medarević Đ
University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, Vojvode Stepe 450, 11221 Belgrade, Serbia.
Čalija B
University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, Vojvode Stepe 450, 11221 Belgrade, Serbia.
Dobričić V
University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: vladimir@pharmacy.bg.ac.rs.
Rmandić M
University of Belgrade, Faculty of Pharmacy, Department of Drug Analysis, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: milena.rmandic@pharmacy.bg.ac.rs.
Barudžija T
University of Belgrade, Vinča Institute of Nuclear Sciences, Laboratory for Theoretical Physics and Condensed Matter Physics, Mike Petrovića Alasa 12-14, 11351 Belgrade, Serbia. Electronic address: tbarudzija@vinca.rs.
Malenović A
University of Belgrade, Faculty of Pharmacy, Department of Drug Analysis, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: andjelija.malenovic@pharmacy.bg.ac.rs.
Djekic L
University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: ljiljanadjek@gmail.com.

MeSH

ChitosanDelayed-Action PreparationsHydrogen-Ion ConcentrationIbuprofenPolyelectrolytesPolysaccharides, BacterialSpectroscopy, Fourier Transform InfraredViscosity

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33278438

Citation

Ćirić, Ana, et al. "Effect of Ibuprofen Entrapment Procedure On Physicochemical and Controlled Drug Release Performances of Chitosan/xanthan Gum Polyelectrolyte Complexes." International Journal of Biological Macromolecules, vol. 167, 2021, pp. 547-558.
Ćirić A, Medarević Đ, Čalija B, et al. Effect of ibuprofen entrapment procedure on physicochemical and controlled drug release performances of chitosan/xanthan gum polyelectrolyte complexes. Int J Biol Macromol. 2021;167:547-558.
Ćirić, A., Medarević, Đ., Čalija, B., Dobričić, V., Rmandić, M., Barudžija, T., Malenović, A., & Djekic, L. (2021). Effect of ibuprofen entrapment procedure on physicochemical and controlled drug release performances of chitosan/xanthan gum polyelectrolyte complexes. International Journal of Biological Macromolecules, 167, 547-558. https://doi.org/10.1016/j.ijbiomac.2020.11.201
Ćirić A, et al. Effect of Ibuprofen Entrapment Procedure On Physicochemical and Controlled Drug Release Performances of Chitosan/xanthan Gum Polyelectrolyte Complexes. Int J Biol Macromol. 2021 Jan 15;167:547-558. PubMed PMID: 33278438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of ibuprofen entrapment procedure on physicochemical and controlled drug release performances of chitosan/xanthan gum polyelectrolyte complexes. AU - Ćirić,Ana, AU - Medarević,Đorđe, AU - Čalija,Bojan, AU - Dobričić,Vladimir, AU - Rmandić,Milena, AU - Barudžija,Tanja, AU - Malenović,Anđelija, AU - Djekic,Ljiljana, Y1 - 2020/12/02/ PY - 2020/07/17/received PY - 2020/09/11/revised PY - 2020/11/29/accepted PY - 2020/12/6/pubmed PY - 2021/4/20/medline PY - 2020/12/5/entrez KW - Chitosan KW - Controlled drug release KW - Drug entrapment KW - Polyelectrolyte complex KW - Polymer crosslinking KW - Xanthan gum SP - 547 EP - 558 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 167 N2 - The effect of the entrapment procedure of a poorly water soluble drug (ibuprofen) on physicochemical and drug release performances of chitosan/xanthan polyelectrolyte complexes (PECs) was investigated to achieve controlled drug release as the ultimate goal. The formation of PECs for two drug entrapment procedures (before or after the mixing of polymers) at pH 4.6 and 5.6 and three chitosan-to-xanthan mass ratios (1:1, 1:2 and 1:3) was observed by continuous decrease in conductivity during the PECs formation and increased apparent viscosity and hysteresis values. The most extensive crosslinking was observed with ibuprofen added before the PECs formation at pH 4.6 and chitosan-to-xanthan mass ratio 1:1. The PECs prepared at polymers' mass ratios 1:2 and 1:3 had higher yield and drug entrapment efficiency. DSC and FT-IR analysis confirmed ibuprofen entrapment in PECs and the partial disruption of its crystallinity. All ibuprofen release profiles were similar, with 60-70% of drug released after 12 h, mainly by diffusion, but erosion and polymer chain relaxation were also included. Potentially optimal can be considered the PEC prepared at pH 4.6, ibuprofen entrapped before the mixing of polymers at chitosan-to-xanthan mass ratio 1:2, which provided controlled drug release by zero-order kinetics, high yield, and drug entrapment efficiency. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/33278438/Effect_of_ibuprofen_entrapment_procedure_on_physicochemical_and_controlled_drug_release_performances_of_chitosan/xanthan_gum_polyelectrolyte_complexes_ DB - PRIME DP - Unbound Medicine ER -