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Combating the Pandemic COVID-19: Clinical Trials, Therapies and Perspectives.
Front Mol Biosci. 2020; 7:606393.FM

Abstract

The coronavirus disease-19 (COVID-19) is caused due to the infection by a unique single stranded enveloped RNA virus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The COVID-19 has claimed many lives around the globe, and a promising solution to end this pandemic is still awaited. Till date neither an exact antiviral drug nor a vaccine is available in the market for public use to cure or control this pandemic. Repurposed drugs and supportive measures are the only available treatment options. This systematic review focuses on different treatment strategies based on various clinical studies. The review discusses all the current treatment plans and probable future strategies obtained as a result of a systematic search in PubMed and Science Direct database. All the possible options for the treatment as well as prophylaxis of COVID-19 are discussed. Apart from this, the article provides details on the clinical trials related to COVID-19, which are registered under ClinicalTrials.gov. Potential of drugs based on the previous researches on SARS-CoV, MERS-CoV, Ebola, influenza, etc. which fall under the same category of coronavirus are also emphasized. Information on cell-based and immunology-based approaches is also provided. In addition, miscellaneous therapeutic approaches and adjunctive therapies are discussed. The drug repurposing options, as evidenced from various in vitro and in silico models, are also covered including the possible future solutions to this pandemic.

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Authors+Show Affiliations

Kotta S
Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Aldawsari HM
Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Badr-Eldin SM
Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia. Department of Pharmaceutics and Industrial Pharmacy, Cairo University, Cairo, Egypt.
Alhakamy NA
Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Md S
Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Nair AB
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.
Deb PK
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University, Amman, Jordan.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33282914

Citation

Kotta, Sabna, et al. "Combating the Pandemic COVID-19: Clinical Trials, Therapies and Perspectives." Frontiers in Molecular Biosciences, vol. 7, 2020, p. 606393.
Kotta S, Aldawsari HM, Badr-Eldin SM, et al. Combating the Pandemic COVID-19: Clinical Trials, Therapies and Perspectives. Front Mol Biosci. 2020;7:606393.
Kotta, S., Aldawsari, H. M., Badr-Eldin, S. M., Alhakamy, N. A., Md, S., Nair, A. B., & Deb, P. K. (2020). Combating the Pandemic COVID-19: Clinical Trials, Therapies and Perspectives. Frontiers in Molecular Biosciences, 7, 606393. https://doi.org/10.3389/fmolb.2020.606393
Kotta S, et al. Combating the Pandemic COVID-19: Clinical Trials, Therapies and Perspectives. Front Mol Biosci. 2020;7:606393. PubMed PMID: 33282914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combating the Pandemic COVID-19: Clinical Trials, Therapies and Perspectives. AU - Kotta,Sabna, AU - Aldawsari,Hibah Mubarak, AU - Badr-Eldin,Shaimaa M, AU - Alhakamy,Nabil Abdulhafiz, AU - Md,Shadab, AU - Nair,Anroop B, AU - Deb,Pran Kishore, Y1 - 2020/11/17/ PY - 2020/09/14/received PY - 2020/10/19/accepted PY - 2020/12/7/entrez PY - 2020/12/8/pubmed PY - 2020/12/8/medline KW - COVID-19 KW - SARS-CoV-2 KW - convalescent plasma therapy KW - drug repurposing KW - vaccine SP - 606393 EP - 606393 JF - Frontiers in molecular biosciences JO - Front Mol Biosci VL - 7 N2 - The coronavirus disease-19 (COVID-19) is caused due to the infection by a unique single stranded enveloped RNA virus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The COVID-19 has claimed many lives around the globe, and a promising solution to end this pandemic is still awaited. Till date neither an exact antiviral drug nor a vaccine is available in the market for public use to cure or control this pandemic. Repurposed drugs and supportive measures are the only available treatment options. This systematic review focuses on different treatment strategies based on various clinical studies. The review discusses all the current treatment plans and probable future strategies obtained as a result of a systematic search in PubMed and Science Direct database. All the possible options for the treatment as well as prophylaxis of COVID-19 are discussed. Apart from this, the article provides details on the clinical trials related to COVID-19, which are registered under ClinicalTrials.gov. Potential of drugs based on the previous researches on SARS-CoV, MERS-CoV, Ebola, influenza, etc. which fall under the same category of coronavirus are also emphasized. Information on cell-based and immunology-based approaches is also provided. In addition, miscellaneous therapeutic approaches and adjunctive therapies are discussed. The drug repurposing options, as evidenced from various in vitro and in silico models, are also covered including the possible future solutions to this pandemic. SN - 2296-889X UR - https://www.unboundmedicine.com/medline/citation/33282914/Combating_the_Pandemic_COVID_19:_Clinical_Trials_Therapies_and_Perspectives_ DB - PRIME DP - Unbound Medicine ER -