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Symptomatic treatment of chronically recurring tension headache: a placebo-controlled, multicenter investigation of Fioricet and acetaminophen with codeine.
Clin Ther 1987; 10(1):69-81CT

Abstract

A double-blind, randomized, multicenter investigation was conducted to compare the efficacy and safety of Fioricet, acetaminophen with codeine, and placebo for the symptomatic treatment of tension headache. At the onset of a typical headache, the patients took two capsules of their assigned study medication and rated responses over the next four hours in three target symptoms areas: pain, emotional or psychic tension, and muscle contractions or stiffness in the head and neck. Physicians made global assessments of the same symptom responses and of adverse reactions for each patient. One hundred ninety-eight patients were evaluated. Both active analgesic preparations were more effective than placebo in relieving pain and muscle stiffness or contractions. Fioricet, but not acetaminophen with codeine, was significantly better than placebo in alleviating emotional or psychic tension; Fioricet was also significantly better than acetaminophen with codeine in relieving this symptom. Certain analyses suggested the possibility that Fioricet had a faster and more sustained analgesic effect than acetaminophen with codeine. By the end of the four-hour trial, significantly more patients achieved complete pain relief with Fioricet than with acetaminophen with codeine. The quality and quantity of adverse reactions did not differ significantly among the treatment groups. None was serious, and all abated without medical intervention.

Authors+Show Affiliations

Neurological Associates of Tucson, Tucson Medical Park, Arizona.No affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

3329967

Citation

Friedman, A P., and F J. DiSerio. "Symptomatic Treatment of Chronically Recurring Tension Headache: a Placebo-controlled, Multicenter Investigation of Fioricet and Acetaminophen With Codeine." Clinical Therapeutics, vol. 10, no. 1, 1987, pp. 69-81.
Friedman AP, DiSerio FJ. Symptomatic treatment of chronically recurring tension headache: a placebo-controlled, multicenter investigation of Fioricet and acetaminophen with codeine. Clin Ther. 1987;10(1):69-81.
Friedman, A. P., & DiSerio, F. J. (1987). Symptomatic treatment of chronically recurring tension headache: a placebo-controlled, multicenter investigation of Fioricet and acetaminophen with codeine. Clinical Therapeutics, 10(1), pp. 69-81.
Friedman AP, DiSerio FJ. Symptomatic Treatment of Chronically Recurring Tension Headache: a Placebo-controlled, Multicenter Investigation of Fioricet and Acetaminophen With Codeine. Clin Ther. 1987;10(1):69-81. PubMed PMID: 3329967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Symptomatic treatment of chronically recurring tension headache: a placebo-controlled, multicenter investigation of Fioricet and acetaminophen with codeine. AU - Friedman,A P, AU - DiSerio,F J, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 69 EP - 81 JF - Clinical therapeutics JO - Clin Ther VL - 10 IS - 1 N2 - A double-blind, randomized, multicenter investigation was conducted to compare the efficacy and safety of Fioricet, acetaminophen with codeine, and placebo for the symptomatic treatment of tension headache. At the onset of a typical headache, the patients took two capsules of their assigned study medication and rated responses over the next four hours in three target symptoms areas: pain, emotional or psychic tension, and muscle contractions or stiffness in the head and neck. Physicians made global assessments of the same symptom responses and of adverse reactions for each patient. One hundred ninety-eight patients were evaluated. Both active analgesic preparations were more effective than placebo in relieving pain and muscle stiffness or contractions. Fioricet, but not acetaminophen with codeine, was significantly better than placebo in alleviating emotional or psychic tension; Fioricet was also significantly better than acetaminophen with codeine in relieving this symptom. Certain analyses suggested the possibility that Fioricet had a faster and more sustained analgesic effect than acetaminophen with codeine. By the end of the four-hour trial, significantly more patients achieved complete pain relief with Fioricet than with acetaminophen with codeine. The quality and quantity of adverse reactions did not differ significantly among the treatment groups. None was serious, and all abated without medical intervention. SN - 0149-2918 UR - https://www.unboundmedicine.com/medline/citation/3329967/Symptomatic_treatment_of_chronically_recurring_tension_headache:_a_placebo-controlled,_multicenter_investigation_of_Fioricet_and_acetaminophen_with_codeine L2 - https://medlineplus.gov/headache.html DB - PRIME DP - Unbound Medicine ER -