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A controlled trial of pentoxifylline (Trental 400) in intermittent claudication: clinical, haemostatic and rheological effects.
N Z Med J. 1987 Jul 22; 100(828):445-7.NZ

Abstract

A formulation of pentoxifylline (Trental 400) has been claimed to increase claudication distance by improving red cell deformability and decreasing blood viscosity and platelet aggregation. In order to test this claim 30 stable claudicants recruited from one population took part in a double-blind randomised trial of placebo versus pentoxifylline. Both placebo and pentoxifylline treated patients improved subjectively and increased their claudication distance over the study period. Analysis of the blood results showed that the only apparent change was a tendency towards increased red cell filtration in the group treated with pentoxifylline; but no significant difference was found between claudicants and normal controls in the degree of red cell filterability nor did red cell filterability correlate with claudication distance. Pentoxifylline did not affect claudication distance or have any useful effect on blood flow properties, calling into question both its efficacy and suggested mode of action.

Authors+Show Affiliations

Accident and Emergency Department, Leicester Royal Infirmary, England.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3330188

Citation

Reilly, D T., et al. "A Controlled Trial of Pentoxifylline (Trental 400) in Intermittent Claudication: Clinical, Haemostatic and Rheological Effects." The New Zealand Medical Journal, vol. 100, no. 828, 1987, pp. 445-7.
Reilly DT, Quinton DN, Barrie WW. A controlled trial of pentoxifylline (Trental 400) in intermittent claudication: clinical, haemostatic and rheological effects. N Z Med J. 1987;100(828):445-7.
Reilly, D. T., Quinton, D. N., & Barrie, W. W. (1987). A controlled trial of pentoxifylline (Trental 400) in intermittent claudication: clinical, haemostatic and rheological effects. The New Zealand Medical Journal, 100(828), 445-7.
Reilly DT, Quinton DN, Barrie WW. A Controlled Trial of Pentoxifylline (Trental 400) in Intermittent Claudication: Clinical, Haemostatic and Rheological Effects. N Z Med J. 1987 Jul 22;100(828):445-7. PubMed PMID: 3330188.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A controlled trial of pentoxifylline (Trental 400) in intermittent claudication: clinical, haemostatic and rheological effects. AU - Reilly,D T, AU - Quinton,D N, AU - Barrie,W W, PY - 1987/7/22/pubmed PY - 1987/7/22/medline PY - 1987/7/22/entrez SP - 445 EP - 7 JF - The New Zealand medical journal JO - N. Z. Med. J. VL - 100 IS - 828 N2 - A formulation of pentoxifylline (Trental 400) has been claimed to increase claudication distance by improving red cell deformability and decreasing blood viscosity and platelet aggregation. In order to test this claim 30 stable claudicants recruited from one population took part in a double-blind randomised trial of placebo versus pentoxifylline. Both placebo and pentoxifylline treated patients improved subjectively and increased their claudication distance over the study period. Analysis of the blood results showed that the only apparent change was a tendency towards increased red cell filtration in the group treated with pentoxifylline; but no significant difference was found between claudicants and normal controls in the degree of red cell filterability nor did red cell filterability correlate with claudication distance. Pentoxifylline did not affect claudication distance or have any useful effect on blood flow properties, calling into question both its efficacy and suggested mode of action. SN - 0028-8446 UR - https://www.unboundmedicine.com/medline/citation/3330188/A_controlled_trial_of_pentoxifylline__Trental_400__in_intermittent_claudication:_clinical_haemostatic_and_rheological_effects_ DB - PRIME DP - Unbound Medicine ER -