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Temporal changes in laboratory markers of survivors and non-survivors of adult inpatients with COVID-19.
BMC Infect Dis. 2020 Dec 11; 20(1):952.BI

Abstract

BACKGROUND

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2, and outbreaks have occurred worldwide. Laboratory test results are an important basis for clinicians to determine patient condition and formulate treatment plans.

METHODS

Fifty-two thousand six hundred forty-four laboratory test results with continuous values of adult inpatients who were diagnosed with COVID-19 and hospitalized in the Fifth Hospital in Wuhan between 16 January 2020 and 18 March 2020 were compiled. The first and last test results were compared between survivors and non-survivors with variance test or Welch test. Laboratory test variables with significant differences were then included in the temporal change analysis.

RESULTS

Among 94 laboratory test variables in 82 survivors and 25 non-survivors with COVID-19, white blood cell count, neutrophil count/percentage, mean platelet volume, platelet distribution width, platelet-large cell percentage, hypersensitive C-reactive protein, procalcitonin, D-dimer, fibrin (ogen) degradation product, middle fluorescent reticulocyte percentage, immature reticulocyte fraction, lactate dehydrogenase were significantly increased (P < 0.05), and lymphocyte count/percentage, monocyte percentage, eosinophil percentage, prothrombin activity, low fluorescent reticulocyte percentage, plasma carbon dioxide, total calcium, prealbumin, total protein, albumin, albumin-globulin ratio, cholinesterase, total cholesterol, nonhigh-density/low-density/small-dense-low-density lipoprotein cholesterol were significantly decreased in non-survivors compared with survivors (P < 0.05), in both first and last tests. Prothrombin time, prothrombin international normalized ratio, nucleated red blood cell count/percentage, high fluorescent reticulocyte percentage, plasma uric acid, plasma urea nitrogen, cystatin C, sodium, phosphorus, magnesium, myoglobin, creatine kinase (isoenzymes), aspartate aminotransferase, alkaline phosphatase, glucose, triglyceride were significantly increased (P < 0.05), and eosinophil count, basophil percentage, platelet count, thrombocytocrit, antithrombin III, red blood cell count, haemoglobin, haematocrit, total carbon dioxide, acidity-basicity, actual bicarbonate radical, base excess in the extracellular fluid compartment, estimated glomerular filtration rate, high-density lipoprotein cholesterol, apolipoprotein A1/ B were significantly decreased in non-survivors compared with survivors (P < 0.05), only in the last tests. Temporal changes in 26 variables, such as lymphocyte count/percentage, neutrophil count/percentage, and platelet count, were obviously different between survivors and non-survivors.

CONCLUSIONS

By the comprehensive usage of the laboratory markers with different temporal changes, patients with a high risk of COVID-19-associated death or progression from mild to severe disease might be identified, allowing for timely targeted treatment.

Authors+Show Affiliations

Department of Intensive Medicine, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, 341000, China.Department of Intensive Medicine, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, 341000, China.Department of Pathogenic Biology, School of Basic Medical Sciences, Gannan Medical University, Ganzhou, 341000, China.Department of Intensive Medicine, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, 341000, China.Department of Respiratory, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, 341000, China.Department of Respiratory, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, 341000, China.Department of Respiratory, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, 341000, China.Department of Pharmacy, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, 341000, China.Department of Pathogenic Biology, School of Basic Medical Sciences, Gannan Medical University, Ganzhou, 341000, China. baiyjqqq@126.com.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

33308159

Citation

Ouyang, Song-Mao, et al. "Temporal Changes in Laboratory Markers of Survivors and Non-survivors of Adult Inpatients With COVID-19." BMC Infectious Diseases, vol. 20, no. 1, 2020, p. 952.
Ouyang SM, Zhu HQ, Xie YN, et al. Temporal changes in laboratory markers of survivors and non-survivors of adult inpatients with COVID-19. BMC Infect Dis. 2020;20(1):952.
Ouyang, S. M., Zhu, H. Q., Xie, Y. N., Zou, Z. S., Zuo, H. M., Rao, Y. W., Liu, X. Y., Zhong, B., & Chen, X. (2020). Temporal changes in laboratory markers of survivors and non-survivors of adult inpatients with COVID-19. BMC Infectious Diseases, 20(1), 952. https://doi.org/10.1186/s12879-020-05678-0
Ouyang SM, et al. Temporal Changes in Laboratory Markers of Survivors and Non-survivors of Adult Inpatients With COVID-19. BMC Infect Dis. 2020 Dec 11;20(1):952. PubMed PMID: 33308159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Temporal changes in laboratory markers of survivors and non-survivors of adult inpatients with COVID-19. AU - Ouyang,Song-Mao, AU - Zhu,Hong-Quan, AU - Xie,Ying-Na, AU - Zou,Zhi-Sheng, AU - Zuo,Hui-Min, AU - Rao,Yun-Wei, AU - Liu,Xiao-Yan, AU - Zhong,Bin, AU - Chen,Xin, Y1 - 2020/12/11/ PY - 2020/08/31/received PY - 2020/12/01/accepted PY - 2020/12/14/entrez PY - 2020/12/15/pubmed PY - 2020/12/19/medline KW - COVID-19 KW - Clinical characteristics KW - Laboratory tests KW - SARS-CoV − 2 KW - Temporal changes SP - 952 EP - 952 JF - BMC infectious diseases JO - BMC Infect Dis VL - 20 IS - 1 N2 - BACKGROUND: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2, and outbreaks have occurred worldwide. Laboratory test results are an important basis for clinicians to determine patient condition and formulate treatment plans. METHODS: Fifty-two thousand six hundred forty-four laboratory test results with continuous values of adult inpatients who were diagnosed with COVID-19 and hospitalized in the Fifth Hospital in Wuhan between 16 January 2020 and 18 March 2020 were compiled. The first and last test results were compared between survivors and non-survivors with variance test or Welch test. Laboratory test variables with significant differences were then included in the temporal change analysis. RESULTS: Among 94 laboratory test variables in 82 survivors and 25 non-survivors with COVID-19, white blood cell count, neutrophil count/percentage, mean platelet volume, platelet distribution width, platelet-large cell percentage, hypersensitive C-reactive protein, procalcitonin, D-dimer, fibrin (ogen) degradation product, middle fluorescent reticulocyte percentage, immature reticulocyte fraction, lactate dehydrogenase were significantly increased (P < 0.05), and lymphocyte count/percentage, monocyte percentage, eosinophil percentage, prothrombin activity, low fluorescent reticulocyte percentage, plasma carbon dioxide, total calcium, prealbumin, total protein, albumin, albumin-globulin ratio, cholinesterase, total cholesterol, nonhigh-density/low-density/small-dense-low-density lipoprotein cholesterol were significantly decreased in non-survivors compared with survivors (P < 0.05), in both first and last tests. Prothrombin time, prothrombin international normalized ratio, nucleated red blood cell count/percentage, high fluorescent reticulocyte percentage, plasma uric acid, plasma urea nitrogen, cystatin C, sodium, phosphorus, magnesium, myoglobin, creatine kinase (isoenzymes), aspartate aminotransferase, alkaline phosphatase, glucose, triglyceride were significantly increased (P < 0.05), and eosinophil count, basophil percentage, platelet count, thrombocytocrit, antithrombin III, red blood cell count, haemoglobin, haematocrit, total carbon dioxide, acidity-basicity, actual bicarbonate radical, base excess in the extracellular fluid compartment, estimated glomerular filtration rate, high-density lipoprotein cholesterol, apolipoprotein A1/ B were significantly decreased in non-survivors compared with survivors (P < 0.05), only in the last tests. Temporal changes in 26 variables, such as lymphocyte count/percentage, neutrophil count/percentage, and platelet count, were obviously different between survivors and non-survivors. CONCLUSIONS: By the comprehensive usage of the laboratory markers with different temporal changes, patients with a high risk of COVID-19-associated death or progression from mild to severe disease might be identified, allowing for timely targeted treatment. SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/33308159/Temporal_changes_in_laboratory_markers_of_survivors_and_non_survivors_of_adult_inpatients_with_COVID_19_ L2 - https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-020-05678-0 DB - PRIME DP - Unbound Medicine ER -