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Controversy over smoking in COVID-19-A real world experience in New York city.
J Med Virol. 2021 07; 93(7):4537-4543.JM

Abstract

Data are conflicting regarding the impact of tobacco smoking in people with pneumonia due to SARS-CoV-2 infection (COVID-19). We performed a retrospective multicentre cohort study of 9991 consecutive patients hospitalized in a major New York academic center between March 7th and June 5th, 2020 with laboratory-confirmed COVID-19. The clinical outcomes assessed included risk of hospitalization, in-hospital mortality, risk of intensive care unit (ICU) admission, and need for mechanical ventilation among smokers (current and former). Multivariable logistic regression and propensity score models were built to adjust for potential confounders. Among 9991 consecutive patients diagnosed with COVID-19, 2212 (22.1%) patients were self-reported smokers (406 current and 1806 former). Current smoking was not associated with an increased risk of hospitalization (propensity score [PS]-adjusted OR 0.91; p = .46), in-hospital mortality (PS-OR 0.77; p = .12), ICU admission (PS-OR 1.18; p = .37), or intubation (PS-OR 1.04; p = .85). Similarly, former smoking was not associated with an increased risk of hospitalization (PS-OR 0.88; p = .11), in-hospital mortality (PS-OR 1.03; p = .78), ICU admission (PS-OR 1.03; p = .95), or intubation (PS-OR 0.93; p = .57). Furthermore, smoking (current or former) was not associated with an increased risk of hospitalization (PS-OR 0.85; p = .05), in-hospital mortality (PS-OR 0.94; p = .49), ICU admission (PS-OR 0.86; p = .17), or intubation (PS-OR 0.79; p = .06). Smoking is a well-known risk factor associated with greater susceptibility and subsequent increased severity of respiratory infections. In the current COVID-19 pandemic, smokers may have increased risk and severe pneumonia. In the current COVID-19 pandemic, smokers are believed to have an increased risk of mortality as well as severe pneumonia. However, in our analysis of real-world clinical data, smoking was not associated with increased in-patient mortality in COVID-19 pneumonia, in accordance with prior reports.

Authors+Show Affiliations

Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.Department of Pulmonary & Critical Care, Icahn School of Medicine at Mount Sinai, New York, USA. Department of Hospice & Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

33325049

Citation

Ho, Kam Sing, et al. "Controversy Over Smoking in COVID-19-A Real World Experience in New York City." Journal of Medical Virology, vol. 93, no. 7, 2021, pp. 4537-4543.
Ho KS, Narasimhan B, Sheehan J, et al. Controversy over smoking in COVID-19-A real world experience in New York city. J Med Virol. 2021;93(7):4537-4543.
Ho, K. S., Narasimhan, B., Sheehan, J., Wu, L., & Fung, J. Y. (2021). Controversy over smoking in COVID-19-A real world experience in New York city. Journal of Medical Virology, 93(7), 4537-4543. https://doi.org/10.1002/jmv.26738
Ho KS, et al. Controversy Over Smoking in COVID-19-A Real World Experience in New York City. J Med Virol. 2021;93(7):4537-4543. PubMed PMID: 33325049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Controversy over smoking in COVID-19-A real world experience in New York city. AU - Ho,Kam Sing, AU - Narasimhan,Bharat, AU - Sheehan,Jacqueline, AU - Wu,LingLing, AU - Fung,Jennifer Y, Y1 - 2021/03/25/ PY - 2020/12/01/revised PY - 2020/09/01/received PY - 2020/12/08/accepted PY - 2020/12/17/pubmed PY - 2021/6/9/medline PY - 2020/12/16/entrez KW - COVID-19 infection KW - ICU admission KW - hospitalization KW - mortality KW - prevalence KW - smoking SP - 4537 EP - 4543 JF - Journal of medical virology JO - J Med Virol VL - 93 IS - 7 N2 - Data are conflicting regarding the impact of tobacco smoking in people with pneumonia due to SARS-CoV-2 infection (COVID-19). We performed a retrospective multicentre cohort study of 9991 consecutive patients hospitalized in a major New York academic center between March 7th and June 5th, 2020 with laboratory-confirmed COVID-19. The clinical outcomes assessed included risk of hospitalization, in-hospital mortality, risk of intensive care unit (ICU) admission, and need for mechanical ventilation among smokers (current and former). Multivariable logistic regression and propensity score models were built to adjust for potential confounders. Among 9991 consecutive patients diagnosed with COVID-19, 2212 (22.1%) patients were self-reported smokers (406 current and 1806 former). Current smoking was not associated with an increased risk of hospitalization (propensity score [PS]-adjusted OR 0.91; p = .46), in-hospital mortality (PS-OR 0.77; p = .12), ICU admission (PS-OR 1.18; p = .37), or intubation (PS-OR 1.04; p = .85). Similarly, former smoking was not associated with an increased risk of hospitalization (PS-OR 0.88; p = .11), in-hospital mortality (PS-OR 1.03; p = .78), ICU admission (PS-OR 1.03; p = .95), or intubation (PS-OR 0.93; p = .57). Furthermore, smoking (current or former) was not associated with an increased risk of hospitalization (PS-OR 0.85; p = .05), in-hospital mortality (PS-OR 0.94; p = .49), ICU admission (PS-OR 0.86; p = .17), or intubation (PS-OR 0.79; p = .06). Smoking is a well-known risk factor associated with greater susceptibility and subsequent increased severity of respiratory infections. In the current COVID-19 pandemic, smokers may have increased risk and severe pneumonia. In the current COVID-19 pandemic, smokers are believed to have an increased risk of mortality as well as severe pneumonia. However, in our analysis of real-world clinical data, smoking was not associated with increased in-patient mortality in COVID-19 pneumonia, in accordance with prior reports. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/33325049/Controversy_over_smoking_in_COVID_19_A_real_world_experience_in_New_York_city_ L2 - https://doi.org/10.1002/jmv.26738 DB - PRIME DP - Unbound Medicine ER -