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The efficacy and mechanisms of a guided self-help intervention based on mindfulness in patients with breast cancer: A randomized controlled trial.
Cancer. 2021 05 01; 127(9):1377-1386.C

Abstract

BACKGROUND

Mindfulness-based interventions (MBIs) can alleviate psychological distress in patients with cancer. However, face-to-face MBIs may be inconvenient for patients. Therefore, guided self-help interventions may be more accessible. The authors investigated the effects of a guided self-help MBI for depression, anxiety, and sleep disorder symptoms in patients with breast cancer and explored the potential underlying mechanisms.

METHODS

One hundred forty-four postoperative patients with breast cancer were randomly assigned to an intervention group (6-week guided self-help MBI; n = 72) or a wait-list control group (routine treatment; n = 72). Self-reported depression, anxiety, sleep disorder symptoms, and rumination and worry as potential mediators were assessed at baseline and postintervention. Outcomes were then assessed at 1-month and 3-month follow-up. The intervention's effects over time and the potential mediating effect were analyzed using generalized estimating equations. The trial was registered at the Chinese Clinical Registry (ChiCTR-IOR-16008073).

RESULTS

Significant improvements in depression and sleep disorder symptoms occurred in the intervention group compared with wait-list controls, and the improvements were maintained at 1-month and 3-month follow-up. Changes in rumination and worry mediated the intervention's effects on changes in depression and sleep disorder symptoms.

CONCLUSIONS

A guided self-help MBI reduced depressive and sleep disorder symptoms by mitigating rumination and worry in patients with breast cancer. These findings support benefits of this accessible psychological intervention in oncology and provide insight into possible mechanisms of action. The current research contributes to discovering effective and widely accessible means for people with physical health conditions and may remove barriers that otherwise would have precluded participation in face-to-face psychological interventions.

Authors+Show Affiliations

Center for Health Management and Policy, School of Public Health, National Health Commission Key Laboratory of Health Economics and Policy, Cheeloo College of Medicine, Shandong University, Jinan, China.Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.School of Nursing, Cheeloo College of Medicine, Shandong University, Jinan, China.School of Nursing, Cheeloo College of Medicine, Shandong University, Jinan, China.Center for Health Management and Policy, School of Public Health, National Health Commission Key Laboratory of Health Economics and Policy, Cheeloo College of Medicine, Shandong University, Jinan, China.School of Nursing, Cheeloo College of Medicine, Shandong University, Jinan, China.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33332582

Citation

Shao, Di, et al. "The Efficacy and Mechanisms of a Guided Self-help Intervention Based On Mindfulness in Patients With Breast Cancer: a Randomized Controlled Trial." Cancer, vol. 127, no. 9, 2021, pp. 1377-1386.
Shao D, Zhang H, Cui N, et al. The efficacy and mechanisms of a guided self-help intervention based on mindfulness in patients with breast cancer: A randomized controlled trial. Cancer. 2021;127(9):1377-1386.
Shao, D., Zhang, H., Cui, N., Sun, J., Li, J., & Cao, F. (2021). The efficacy and mechanisms of a guided self-help intervention based on mindfulness in patients with breast cancer: A randomized controlled trial. Cancer, 127(9), 1377-1386. https://doi.org/10.1002/cncr.33381
Shao D, et al. The Efficacy and Mechanisms of a Guided Self-help Intervention Based On Mindfulness in Patients With Breast Cancer: a Randomized Controlled Trial. Cancer. 2021 05 1;127(9):1377-1386. PubMed PMID: 33332582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The efficacy and mechanisms of a guided self-help intervention based on mindfulness in patients with breast cancer: A randomized controlled trial. AU - Shao,Di, AU - Zhang,Huihui, AU - Cui,Naixue, AU - Sun,Jiwei, AU - Li,Jie, AU - Cao,Fenglin, Y1 - 2020/12/17/ PY - 2020/10/13/revised PY - 2020/03/10/received PY - 2020/11/25/accepted PY - 2020/12/18/pubmed PY - 2020/12/18/medline PY - 2020/12/17/entrez KW - breast cancer KW - depression KW - mindfulness-based intervention KW - self-help SP - 1377 EP - 1386 JF - Cancer JO - Cancer VL - 127 IS - 9 N2 - BACKGROUND: Mindfulness-based interventions (MBIs) can alleviate psychological distress in patients with cancer. However, face-to-face MBIs may be inconvenient for patients. Therefore, guided self-help interventions may be more accessible. The authors investigated the effects of a guided self-help MBI for depression, anxiety, and sleep disorder symptoms in patients with breast cancer and explored the potential underlying mechanisms. METHODS: One hundred forty-four postoperative patients with breast cancer were randomly assigned to an intervention group (6-week guided self-help MBI; n = 72) or a wait-list control group (routine treatment; n = 72). Self-reported depression, anxiety, sleep disorder symptoms, and rumination and worry as potential mediators were assessed at baseline and postintervention. Outcomes were then assessed at 1-month and 3-month follow-up. The intervention's effects over time and the potential mediating effect were analyzed using generalized estimating equations. The trial was registered at the Chinese Clinical Registry (ChiCTR-IOR-16008073). RESULTS: Significant improvements in depression and sleep disorder symptoms occurred in the intervention group compared with wait-list controls, and the improvements were maintained at 1-month and 3-month follow-up. Changes in rumination and worry mediated the intervention's effects on changes in depression and sleep disorder symptoms. CONCLUSIONS: A guided self-help MBI reduced depressive and sleep disorder symptoms by mitigating rumination and worry in patients with breast cancer. These findings support benefits of this accessible psychological intervention in oncology and provide insight into possible mechanisms of action. The current research contributes to discovering effective and widely accessible means for people with physical health conditions and may remove barriers that otherwise would have precluded participation in face-to-face psychological interventions. SN - 1097-0142 UR - https://www.unboundmedicine.com/medline/citation/33332582/The_efficacy_and_mechanisms_of_a_guided_self_help_intervention_based_on_mindfulness_in_patients_with_breast_cancer:_A_randomized_controlled_trial_ L2 - https://doi.org/10.1002/cncr.33381 DB - PRIME DP - Unbound Medicine ER -