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Possible treatment and strategies for COVID-19: review and assessment.
Eur Rev Med Pharmacol Sci. 2020 12; 24(23):12593-12608.ER

Abstract

The coronavirus disease 2019 (COVID-19) is declared as an international emergency in 2020. Its prevalence and fatality rate are rapidly increasing but the medication options are still limited for this perilous disease. The emergent outbreak of COVID-19 triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) keeps propagating globally. The present scenario has emphasized the requirement for therapeutic opportunities to relive and overcome this latest pandemic. Despite the fact, the deteriorating developments of COVID-19, there is no drug certified to have considerable effects in the medical treatment for COVID-19 patients. The COVID-19 pandemic requests for the rapid testing of new treatment approaches. Based on the evidence, hydroxychloroquine is the first medicine opted for the treatment of disease. Umifenovir, remdesivir, and fevipiravir are deemed the most hopeful antiviral agent by improving the health of infected patients. The dexamethasone is a first known steroid medicine that can save the lives of seriously ill patients, and it is shown in a randomized clinical trial by the United Kingdom that it reduced the death rate in COVID-19 patients. The current review recapitulates the existing evidence of possible therapeutic drugs, peptides, humanized antibodies, convulsant plasma, and vaccination that has revealed potential in fighting COVID-19 infections. Many randomized and controlled clinical trials are taking place to further validate these agent's safety and effectiveness in curing COVID-19.

Authors+Show Affiliations

Department of Neurological Sciences, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE, USA. devendra.kumar@unmc.edu.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33336780

Citation

Trivedi, N, et al. "Possible Treatment and Strategies for COVID-19: Review and Assessment." European Review for Medical and Pharmacological Sciences, vol. 24, no. 23, 2020, pp. 12593-12608.
Trivedi N, Verma A, Kumar D. Possible treatment and strategies for COVID-19: review and assessment. Eur Rev Med Pharmacol Sci. 2020;24(23):12593-12608.
Trivedi, N., Verma, A., & Kumar, D. (2020). Possible treatment and strategies for COVID-19: review and assessment. European Review for Medical and Pharmacological Sciences, 24(23), 12593-12608. https://doi.org/10.26355/eurrev_202012_24057
Trivedi N, Verma A, Kumar D. Possible Treatment and Strategies for COVID-19: Review and Assessment. Eur Rev Med Pharmacol Sci. 2020;24(23):12593-12608. PubMed PMID: 33336780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible treatment and strategies for COVID-19: review and assessment. AU - Trivedi,N, AU - Verma,A, AU - Kumar,D, PY - 2020/12/18/entrez PY - 2020/12/19/pubmed PY - 2021/1/2/medline SP - 12593 EP - 12608 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 24 IS - 23 N2 - The coronavirus disease 2019 (COVID-19) is declared as an international emergency in 2020. Its prevalence and fatality rate are rapidly increasing but the medication options are still limited for this perilous disease. The emergent outbreak of COVID-19 triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) keeps propagating globally. The present scenario has emphasized the requirement for therapeutic opportunities to relive and overcome this latest pandemic. Despite the fact, the deteriorating developments of COVID-19, there is no drug certified to have considerable effects in the medical treatment for COVID-19 patients. The COVID-19 pandemic requests for the rapid testing of new treatment approaches. Based on the evidence, hydroxychloroquine is the first medicine opted for the treatment of disease. Umifenovir, remdesivir, and fevipiravir are deemed the most hopeful antiviral agent by improving the health of infected patients. The dexamethasone is a first known steroid medicine that can save the lives of seriously ill patients, and it is shown in a randomized clinical trial by the United Kingdom that it reduced the death rate in COVID-19 patients. The current review recapitulates the existing evidence of possible therapeutic drugs, peptides, humanized antibodies, convulsant plasma, and vaccination that has revealed potential in fighting COVID-19 infections. Many randomized and controlled clinical trials are taking place to further validate these agent's safety and effectiveness in curing COVID-19. SN - 2284-0729 UR - https://www.unboundmedicine.com/medline/citation/33336780/Possible_treatment_and_strategies_for_COVID_19:_review_and_assessment_ L2 - https://www.europeanreview.org/article/24057 DB - PRIME DP - Unbound Medicine ER -