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Coronavirus vaccine development: from SARS and MERS to COVID-19.
J Biomed Sci. 2020 Dec 20; 27(1):104.JB

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new type of coronavirus that causes the Coronavirus Disease 2019 (COVID-19), which has been the most challenging pandemic in this century. Considering its high mortality and rapid spread, an effective vaccine is urgently needed to control this pandemic. As a result, the academia, industry, and government sectors are working tightly together to develop and test a variety of vaccines at an unprecedented pace. In this review, we outline the essential coronavirus biological characteristics that are important for vaccine design. In addition, we summarize key takeaways from previous vaccination studies of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV), highlighting the pros and cons of each immunization strategy. Finally, based on these prior vaccination experiences, we discuss recent progress and potential challenges of COVID-19 vaccine development.

Authors+Show Affiliations

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. wutc@jhmi.edu. Johns Hopkins School of Medicine, 1550 Orleans St, CRB II - Room 309, Baltimore, MD, 21287, USA. wutc@jhmi.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33341119

Citation

Li, Yen-Der, et al. "Coronavirus Vaccine Development: From SARS and MERS to COVID-19." Journal of Biomedical Science, vol. 27, no. 1, 2020, p. 104.
Li YD, Chi WY, Su JH, et al. Coronavirus vaccine development: from SARS and MERS to COVID-19. J Biomed Sci. 2020;27(1):104.
Li, Y. D., Chi, W. Y., Su, J. H., Ferrall, L., Hung, C. F., & Wu, T. C. (2020). Coronavirus vaccine development: from SARS and MERS to COVID-19. Journal of Biomedical Science, 27(1), 104. https://doi.org/10.1186/s12929-020-00695-2
Li YD, et al. Coronavirus Vaccine Development: From SARS and MERS to COVID-19. J Biomed Sci. 2020 Dec 20;27(1):104. PubMed PMID: 33341119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coronavirus vaccine development: from SARS and MERS to COVID-19. AU - Li,Yen-Der, AU - Chi,Wei-Yu, AU - Su,Jun-Han, AU - Ferrall,Louise, AU - Hung,Chien-Fu, AU - Wu,T-C, Y1 - 2020/12/20/ PY - 2020/10/30/received PY - 2020/11/20/accepted PY - 2020/12/20/entrez PY - 2020/12/21/pubmed PY - 2020/12/29/medline KW - Coronaviruses KW - SARS-CoV-2 KW - Vaccine KW - Vaccine development SP - 104 EP - 104 JF - Journal of biomedical science JO - J Biomed Sci VL - 27 IS - 1 N2 - Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new type of coronavirus that causes the Coronavirus Disease 2019 (COVID-19), which has been the most challenging pandemic in this century. Considering its high mortality and rapid spread, an effective vaccine is urgently needed to control this pandemic. As a result, the academia, industry, and government sectors are working tightly together to develop and test a variety of vaccines at an unprecedented pace. In this review, we outline the essential coronavirus biological characteristics that are important for vaccine design. In addition, we summarize key takeaways from previous vaccination studies of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV), highlighting the pros and cons of each immunization strategy. Finally, based on these prior vaccination experiences, we discuss recent progress and potential challenges of COVID-19 vaccine development. SN - 1423-0127 UR - https://www.unboundmedicine.com/medline/citation/33341119/Coronavirus_vaccine_development:_from_SARS_and_MERS_to_COVID_19_ L2 - https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-020-00695-2 DB - PRIME DP - Unbound Medicine ER -