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COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular Traps.
Mediators Inflamm. 2020; 2020:8829674.MI

Abstract

Coronavirus disease 2019 (COVID-19) is a virus-induced respiratory disease that may progress to acute respiratory distress syndrome (ARDS) and is triggered by immunopathological mechanisms that cause excessive inflammation and leukocyte dysfunction. Neutrophils play a critical function in the clearance of bacteria with specific mechanisms to combat viruses. The aim of this review is to highlight the current advances in the pathways of neutrophilic inflammation against viral infection over the past ten years, focusing on the production of neutrophil extracellular traps (NETs) and its impact on severe lung diseases, such as COVID-19. We focused on studies regarding hyperinflammation, cytokine storms, neutrophil function, and viral infections. We discuss how the neutrophil's role could influence COVID-19 symptoms in the interaction between hyperinflammation (overproduction of NETs and cytokines) and the clearance function of neutrophils to eliminate the viral infection. We also propose a more in-depth investigation into the neutrophil response mechanism targeting NETosis in the different phases of COVID-19.

Authors+Show Affiliations

Instituto de Ciências da Atividade Física e Esportes (ICAFE), Universidade Cruzeiro do Sul, São Paulo, SP, Brazil.Instituto de Ciências da Atividade Física e Esportes (ICAFE), Universidade Cruzeiro do Sul, São Paulo, SP, Brazil.Instituto de Ciências da Atividade Física e Esportes (ICAFE), Universidade Cruzeiro do Sul, São Paulo, SP, Brazil. Instituto Butantan, São Paulo, SP, Brazil.Instituto de Ciências da Atividade Física e Esportes (ICAFE), Universidade Cruzeiro do Sul, São Paulo, SP, Brazil.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33343232

Citation

Borges, Leandro, et al. "COVID-19 and Neutrophils: the Relationship Between Hyperinflammation and Neutrophil Extracellular Traps." Mediators of Inflammation, vol. 2020, 2020, p. 8829674.
Borges L, Pithon-Curi TC, Curi R, et al. COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular Traps. Mediators Inflamm. 2020;2020:8829674.
Borges, L., Pithon-Curi, T. C., Curi, R., & Hatanaka, E. (2020). COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular Traps. Mediators of Inflammation, 2020, 8829674. https://doi.org/10.1155/2020/8829674
Borges L, et al. COVID-19 and Neutrophils: the Relationship Between Hyperinflammation and Neutrophil Extracellular Traps. Mediators Inflamm. 2020;2020:8829674. PubMed PMID: 33343232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular Traps. AU - Borges,Leandro, AU - Pithon-Curi,Tania Cristina, AU - Curi,Rui, AU - Hatanaka,Elaine, Y1 - 2020/12/02/ PY - 2020/09/08/received PY - 2020/11/15/revised PY - 2020/11/25/accepted PY - 2020/12/21/entrez PY - 2020/12/22/pubmed PY - 2020/12/22/medline SP - 8829674 EP - 8829674 JF - Mediators of inflammation JO - Mediators Inflamm VL - 2020 N2 - Coronavirus disease 2019 (COVID-19) is a virus-induced respiratory disease that may progress to acute respiratory distress syndrome (ARDS) and is triggered by immunopathological mechanisms that cause excessive inflammation and leukocyte dysfunction. Neutrophils play a critical function in the clearance of bacteria with specific mechanisms to combat viruses. The aim of this review is to highlight the current advances in the pathways of neutrophilic inflammation against viral infection over the past ten years, focusing on the production of neutrophil extracellular traps (NETs) and its impact on severe lung diseases, such as COVID-19. We focused on studies regarding hyperinflammation, cytokine storms, neutrophil function, and viral infections. We discuss how the neutrophil's role could influence COVID-19 symptoms in the interaction between hyperinflammation (overproduction of NETs and cytokines) and the clearance function of neutrophils to eliminate the viral infection. We also propose a more in-depth investigation into the neutrophil response mechanism targeting NETosis in the different phases of COVID-19. SN - 1466-1861 UR - https://www.unboundmedicine.com/medline/citation/33343232/COVID_19_and_Neutrophils:_The_Relationship_between_Hyperinflammation_and_Neutrophil_Extracellular_Traps_ DB - PRIME DP - Unbound Medicine ER -