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Relationship Between Anti-Müllerian Hormone and In Vitro Fertilization-Embryo Transfer in Clinical Pregnancy.
Front Endocrinol (Lausanne). 2020; 11:595448.FE

Abstract

Objectives

To retrospectively analyze the correlation between anti-Müllerian hormone (AMH) and the number of oocytes obtained by controlled ovarian hyperstimulation (COH) in women of different ages and explore the factors affecting in vitro fertilization and embryo transfer (IVF-ET) in clinical pregnancy of infertile women to provide evidence for infertile women to choose assisted reproduction strategies.

Methods

Infertile women who received IVF-ET or intracytoplasmic sperm injection and embryo transfer (ICSI-ET) treatment in the reproductive center of XX hospital between October 2018 and September 2019 were included. Patient data on medical records, age, body mass index (BMI), years of infertility, basic follicle-stimulating hormone (FSH), basic luteinizing hormone (LH), basic estradiol (E2), anti-Müllerian hormone level (AMH), antral follicle count (AFC), gonadotropins (Gn) medication days, Gn dosage, endometrial thickness on transplantation day, the number of retrieved oocytes, the number of mature oocytes obtained, the number of embryos transferred, clinical pregnancy status, etc., were collected.

Results

A total of 314 patients were enrolled in this study, with an average age of 31.0 ± 4.5 years. The infertility period ranged from 0-21 years. The AMH level showed a downward trend with increasing age. Overall, the AMH level of women of all ages was positively correlated with the number of retrieved oocytes (r = 0.335, p < 0.001). The AMH level of women between 22 and 28 years old was positively correlated with the number of retrieved oocytes (r = 0.164, p < 0.061) but it was not statistically significant. Similarly, the AMH level of women aged 29-35 and 36-43 was positively correlated with the number of retrieved oocytes (r = 0.356, p < 0.001; r = 0.461, p < 0.001). The average age of the pregnant group (30.6 ± 4.4 years) was lower than that of the non-pregnant group (32.2 ± 4.6 years) (p < 0.001). The number of oocytes obtained (9.8 ± 4.5) and the number of embryos transferred (1.9 ± 0.4) in the pregnant group was significantly higher than that in the non-pregnant group (9.2 ± 4.5; 1.7 ± 0.5); the difference was statistically significant. The multivariate logistic regression model showed that age (OR = 0.574 95% CI: 0.350-0.940), AMH (OR = 1.430 95% CI: 1.130-1.820) and the number of oocytes obtained (OR = 1.360 95% CI: 1.030-1.790) were factors affecting clinical pregnancy.

Conclusion

We found that the level of AMH in infertile women decreased with age and the number of oocytes obtained in infertile women was positively correlated with AMH. Moreover, the number of oocytes and embryo transferred in the pregnant group was significantly higher than those in the non-pregnant group. Furthermore, age, AMH and the number of oocytes affected the clinical pregnancy.

Links

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Authors+Show Affiliations

Sun XY
Department of Obstetrics and Gynecology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Lan YZ
Department of Reproductive Center, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Liu S
Department of Reproductive Center, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Long XP
Department of Obstetrics and Gynecology, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.
Mao XG
Department of Obstetrics and Gynecology, The Affiliated Hospital of Southwest Medical University, Luzhou, China. Department of Obstetrics and Gynecology, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.
Liu L
Department of Reproductive Center, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

MeSH

AdultAnti-Mullerian HormoneEmbryo TransferFemaleFertilization in VitroHumansInfertility, FemaleOocyte RetrievalOocytesOvulation InductionPregnancyRetrospective StudiesYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33343511

Citation

Sun, Xing Yu, et al. "Relationship Between Anti-Müllerian Hormone and in Vitro Fertilization-Embryo Transfer in Clinical Pregnancy." Frontiers in Endocrinology, vol. 11, 2020, p. 595448.
Sun XY, Lan YZ, Liu S, et al. Relationship Between Anti-Müllerian Hormone and In Vitro Fertilization-Embryo Transfer in Clinical Pregnancy. Front Endocrinol (Lausanne). 2020;11:595448.
Sun, X. Y., Lan, Y. Z., Liu, S., Long, X. P., Mao, X. G., & Liu, L. (2020). Relationship Between Anti-Müllerian Hormone and In Vitro Fertilization-Embryo Transfer in Clinical Pregnancy. Frontiers in Endocrinology, 11, 595448. https://doi.org/10.3389/fendo.2020.595448
Sun XY, et al. Relationship Between Anti-Müllerian Hormone and in Vitro Fertilization-Embryo Transfer in Clinical Pregnancy. Front Endocrinol (Lausanne). 2020;11:595448. PubMed PMID: 33343511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship Between Anti-Müllerian Hormone and In Vitro Fertilization-Embryo Transfer in Clinical Pregnancy. AU - Sun,Xing Yu, AU - Lan,Yun Zhu, AU - Liu,Shuang, AU - Long,Xiao Ping, AU - Mao,Xi Guang, AU - Liu,Ling, Y1 - 2020/12/04/ PY - 2020/08/18/received PY - 2020/11/05/accepted PY - 2020/12/21/entrez PY - 2020/12/22/pubmed PY - 2021/5/22/medline KW - anti-Müllerian hormone KW - assisted reproductive technologies KW - in vitro fertilization-embryo transfer KW - infertile women KW - pregnancy SP - 595448 EP - 595448 JF - Frontiers in endocrinology JO - Front Endocrinol (Lausanne) VL - 11 N2 - Objectives: To retrospectively analyze the correlation between anti-Müllerian hormone (AMH) and the number of oocytes obtained by controlled ovarian hyperstimulation (COH) in women of different ages and explore the factors affecting in vitro fertilization and embryo transfer (IVF-ET) in clinical pregnancy of infertile women to provide evidence for infertile women to choose assisted reproduction strategies. Methods: Infertile women who received IVF-ET or intracytoplasmic sperm injection and embryo transfer (ICSI-ET) treatment in the reproductive center of XX hospital between October 2018 and September 2019 were included. Patient data on medical records, age, body mass index (BMI), years of infertility, basic follicle-stimulating hormone (FSH), basic luteinizing hormone (LH), basic estradiol (E2), anti-Müllerian hormone level (AMH), antral follicle count (AFC), gonadotropins (Gn) medication days, Gn dosage, endometrial thickness on transplantation day, the number of retrieved oocytes, the number of mature oocytes obtained, the number of embryos transferred, clinical pregnancy status, etc., were collected. Results: A total of 314 patients were enrolled in this study, with an average age of 31.0 ± 4.5 years. The infertility period ranged from 0-21 years. The AMH level showed a downward trend with increasing age. Overall, the AMH level of women of all ages was positively correlated with the number of retrieved oocytes (r = 0.335, p < 0.001). The AMH level of women between 22 and 28 years old was positively correlated with the number of retrieved oocytes (r = 0.164, p < 0.061) but it was not statistically significant. Similarly, the AMH level of women aged 29-35 and 36-43 was positively correlated with the number of retrieved oocytes (r = 0.356, p < 0.001; r = 0.461, p < 0.001). The average age of the pregnant group (30.6 ± 4.4 years) was lower than that of the non-pregnant group (32.2 ± 4.6 years) (p < 0.001). The number of oocytes obtained (9.8 ± 4.5) and the number of embryos transferred (1.9 ± 0.4) in the pregnant group was significantly higher than that in the non-pregnant group (9.2 ± 4.5; 1.7 ± 0.5); the difference was statistically significant. The multivariate logistic regression model showed that age (OR = 0.574 95% CI: 0.350-0.940), AMH (OR = 1.430 95% CI: 1.130-1.820) and the number of oocytes obtained (OR = 1.360 95% CI: 1.030-1.790) were factors affecting clinical pregnancy. Conclusion: We found that the level of AMH in infertile women decreased with age and the number of oocytes obtained in infertile women was positively correlated with AMH. Moreover, the number of oocytes and embryo transferred in the pregnant group was significantly higher than those in the non-pregnant group. Furthermore, age, AMH and the number of oocytes affected the clinical pregnancy. SN - 1664-2392 UR - https://www.unboundmedicine.com/medline/citation/33343511/Relationship_Between_Anti_Müllerian_Hormone_and_In_Vitro_Fertilization_Embryo_Transfer_in_Clinical_Pregnancy_ DB - PRIME DP - Unbound Medicine ER -