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Coronavirus 229E with Rhinovirus co-infection causing severe acute respiratory distress syndrome with thrombotic microangiopathy and death during Covid-19 pandemic: lessons to be learnt.
Autops Case Rep. 2020 Aug 14; 10(3):e2020194.AC

Abstract

We report on a 3-month old infant male who had a seven-days history of fever and rhinorrhea associated with wheezing prior to his death, during the Covid-19 pandemic. Viral testing for Covid-19 (SARS-CoV-2) was negative but was positive for Coronavirus 229E and RP Human Rhinovirus. The pulmonary histological examination showed diffuse alveolar damage along with thrombotic microangiopathy affecting alveolar capillaries. Also, thrombotic microangiopathy was evident in the heart, lungs, brain, kidneys and liver. Thrombotic microangiopathy is a major pathologic finding in Acute Respiratory Distress Syndrome and in the multiorgan failure. This is the first report that illustrates thrombotic microangiopathy occurring in lung, heart, liver, kidney and brain in Acute Respiratory Distress Syndrome with Coronavirus 229E with Rhinovirus co-infection. The clinical presentation and pathological findings in our case share common features with Covid-19.

Authors+Show Affiliations

General Hospital San Fernando, Department of Pathology, Trinidad, West Indies.General Hospital San Fernando, Department of Pathology, Trinidad, West Indies.Scarborough General Hospital, Department of Accident and Emergency, Tobago, West Indies.General Hospital San Fernando, Department of Pathology, Trinidad, West Indies.General Hospital San Fernando, Department of Pathology, Trinidad, West Indies.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

33344304

Citation

Daisley, Hubert, et al. "Coronavirus 229E With Rhinovirus Co-infection Causing Severe Acute Respiratory Distress Syndrome With Thrombotic Microangiopathy and Death During Covid-19 Pandemic: Lessons to Be Learnt." Autopsy & Case Reports, vol. 10, no. 3, 2020, pp. e2020194.
Daisley H, Rampersad A, Daisley M, et al. Coronavirus 229E with Rhinovirus co-infection causing severe acute respiratory distress syndrome with thrombotic microangiopathy and death during Covid-19 pandemic: lessons to be learnt. Autops Case Rep. 2020;10(3):e2020194.
Daisley, H., Rampersad, A., Daisley, M., Ramdin, A., & Acco, O. (2020). Coronavirus 229E with Rhinovirus co-infection causing severe acute respiratory distress syndrome with thrombotic microangiopathy and death during Covid-19 pandemic: lessons to be learnt. Autopsy & Case Reports, 10(3), e2020194. https://doi.org/10.4322/acr.2020.194
Daisley H, et al. Coronavirus 229E With Rhinovirus Co-infection Causing Severe Acute Respiratory Distress Syndrome With Thrombotic Microangiopathy and Death During Covid-19 Pandemic: Lessons to Be Learnt. Autops Case Rep. 2020 Aug 14;10(3):e2020194. PubMed PMID: 33344304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coronavirus 229E with Rhinovirus co-infection causing severe acute respiratory distress syndrome with thrombotic microangiopathy and death during Covid-19 pandemic: lessons to be learnt. AU - Daisley,Hubert,Jr AU - Rampersad,Arlene, AU - Daisley,Martina, AU - Ramdin,Amit, AU - Acco,Oneka, Y1 - 2020/08/14/ PY - 2020/12/21/entrez PY - 2020/12/22/pubmed PY - 2020/12/22/medline KW - Coronavirus infections KW - Respiratory Distress Syndrome, Adult KW - Rhinovirus KW - SARS virus KW - Thrombotic Microangiopathies SP - e2020194 EP - e2020194 JF - Autopsy & case reports JO - Autops Case Rep VL - 10 IS - 3 N2 - We report on a 3-month old infant male who had a seven-days history of fever and rhinorrhea associated with wheezing prior to his death, during the Covid-19 pandemic. Viral testing for Covid-19 (SARS-CoV-2) was negative but was positive for Coronavirus 229E and RP Human Rhinovirus. The pulmonary histological examination showed diffuse alveolar damage along with thrombotic microangiopathy affecting alveolar capillaries. Also, thrombotic microangiopathy was evident in the heart, lungs, brain, kidneys and liver. Thrombotic microangiopathy is a major pathologic finding in Acute Respiratory Distress Syndrome and in the multiorgan failure. This is the first report that illustrates thrombotic microangiopathy occurring in lung, heart, liver, kidney and brain in Acute Respiratory Distress Syndrome with Coronavirus 229E with Rhinovirus co-infection. The clinical presentation and pathological findings in our case share common features with Covid-19. SN - 2236-1960 UR - https://www.unboundmedicine.com/medline/citation/33344304/Coronavirus_229E_with_Rhinovirus_co_infection_causing_severe_acute_respiratory_distress_syndrome_with_thrombotic_microangiopathy_and_death_during_Covid_19_pandemic:_lessons_to_be_learnt_ L2 - https://doi.org/10.4322/acr.2020.194 DB - PRIME DP - Unbound Medicine ER -
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