Tags

Type your tag names separated by a space and hit enter

Relationship Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Etiology of Acute Kidney Injury (AKI).
Am J Med Sci. 2021 03; 361(3):287-296.AJ

Abstract

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since it was first recognized in December 2019, it has resulted in the ongoing worldwide pandemic. Although acute hypoxic respiratory failure (AHRF) and acute respiratory distress syndrome (ARDS) are the main features of the disease, the involvement of other organs needs to be explored. There has been a growing concern regarding the association between acute kidney injury (AKI) and poor outcomes in SARS-CoV-2 patients. Based on current observational data, AKI is the 2nd most common cause of morbidity and mortality behind ARDS in SARS-CoV-2 patients. Angiotensin-converting enzyme 2 (ACE2) receptor has been shown to be the cornerstone of SARS-CoV-2 infection and possibly plays a significant role in the occurrence of renal injury. The pathogenesis of AKI is likely multifactorial that involves not only direct viral invasion but also dysregulated immune response in the form of cytokine storm, ischemia to kidneys, hypercoagulable state, and rhabdomyolysis, among others. We performed a literature search of the Pubmed and Google Scholar database from 1996 to 2020 using the following keywords: severe acute respiratory syndrome coronavirus 2, coronavirus disease 2019, angiotensin-converting enzyme 2 receptor, and acute kidney injury to find the most pertinent and highest-quality of evidence. Any cited references were reviewed to identify relevant literature. The purpose of this review is to discuss, explore, and summarize the relationship between AKI in SARS-CoV-2 patients, with a focus on its epidemiology, association with ACE2 receptors, and pathophysiology of AKI.

Authors+Show Affiliations

Department of Pulmonary and Critical Care Medicine; Albany Medical Center, Albany, New York, USA. Electronic address: Keenanchong15@gmail.com.Department of Pulmonary and Critical Care; Ozarks Medical Center, West Plains, Missouri, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33358501

Citation

Chong, Woon H., and Biplab K. Saha. "Relationship Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Etiology of Acute Kidney Injury (AKI)." The American Journal of the Medical Sciences, vol. 361, no. 3, 2021, pp. 287-296.
Chong WH, Saha BK. Relationship Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Etiology of Acute Kidney Injury (AKI). Am J Med Sci. 2021;361(3):287-296.
Chong, W. H., & Saha, B. K. (2021). Relationship Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Etiology of Acute Kidney Injury (AKI). The American Journal of the Medical Sciences, 361(3), 287-296. https://doi.org/10.1016/j.amjms.2020.10.025
Chong WH, Saha BK. Relationship Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Etiology of Acute Kidney Injury (AKI). Am J Med Sci. 2021;361(3):287-296. PubMed PMID: 33358501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Etiology of Acute Kidney Injury (AKI). AU - Chong,Woon H, AU - Saha,Biplab K, Y1 - 2020/10/27/ PY - 2020/05/20/received PY - 2020/10/23/accepted PY - 2020/12/29/pubmed PY - 2021/3/27/medline PY - 2020/12/28/entrez KW - Acute Kidney Injury KW - COVID-19 KW - Etiology KW - SARS-CoV-2 KW - Severe Acute Respiratory Syndrome Coronavirus 2 SP - 287 EP - 296 JF - The American journal of the medical sciences JO - Am J Med Sci VL - 361 IS - 3 N2 - Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since it was first recognized in December 2019, it has resulted in the ongoing worldwide pandemic. Although acute hypoxic respiratory failure (AHRF) and acute respiratory distress syndrome (ARDS) are the main features of the disease, the involvement of other organs needs to be explored. There has been a growing concern regarding the association between acute kidney injury (AKI) and poor outcomes in SARS-CoV-2 patients. Based on current observational data, AKI is the 2nd most common cause of morbidity and mortality behind ARDS in SARS-CoV-2 patients. Angiotensin-converting enzyme 2 (ACE2) receptor has been shown to be the cornerstone of SARS-CoV-2 infection and possibly plays a significant role in the occurrence of renal injury. The pathogenesis of AKI is likely multifactorial that involves not only direct viral invasion but also dysregulated immune response in the form of cytokine storm, ischemia to kidneys, hypercoagulable state, and rhabdomyolysis, among others. We performed a literature search of the Pubmed and Google Scholar database from 1996 to 2020 using the following keywords: severe acute respiratory syndrome coronavirus 2, coronavirus disease 2019, angiotensin-converting enzyme 2 receptor, and acute kidney injury to find the most pertinent and highest-quality of evidence. Any cited references were reviewed to identify relevant literature. The purpose of this review is to discuss, explore, and summarize the relationship between AKI in SARS-CoV-2 patients, with a focus on its epidemiology, association with ACE2 receptors, and pathophysiology of AKI. SN - 1538-2990 UR - https://www.unboundmedicine.com/medline/citation/33358501/Relationship_Between_Severe_Acute_Respiratory_Syndrome_Coronavirus_2__SARS_CoV_2__and_the_Etiology_of_Acute_Kidney_Injury__AKI__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9629(20)30478-X DB - PRIME DP - Unbound Medicine ER -