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The Current Status of Drug Repositioning and Vaccine Developments for the COVID-19 Pandemic.
Int J Mol Sci. 2020 Dec 21; 21(24)IJ

Abstract

Since the outbreak of coronavirus disease 2019 (COVID-19) was first identified, the world has vehemently worked to develop treatments and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at an unprecedented speed. Few of the repositioned drugs for COVID-19 have shown that they were efficacious and safe. In contrast, a couple of vaccines against SARS-CoV-2 will be ready for mass rollout early next year. Despite successful vaccine development for COVID-19, the world will face a whole new set of challenges including scale-up manufacturing, cold-chain logistics, long-term safety, and low vaccine acceptance. We highlighted the importance of knowledge sharing and collaboration to find innovative answers to these challenges and to prepare for newly emerging viruses.

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Authors+Show Affiliations

Won JH
Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Korea. Center for Convergence Approaches in Drug Development, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Korea.
Lee H
Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Korea. Center for Convergence Approaches in Drug Development, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Korea. Department of Clinical Pharmacology and Therapeutics, College of Medicine, Seoul National University, Seoul 03080, Korea. Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul 03080, Korea. Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 16229, Korea.

MeSH

AntimalarialsAntiviral AgentsCOVID-19COVID-19 VaccinesChloroquineDrug RepositioningHumansHydroxychloroquineNucleosidesPandemicsProtease InhibitorsPublic HealthSARS-CoV-2COVID-19 Drug Treatment

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33371468

Citation

Won, Jung-Hyun, and Howard Lee. "The Current Status of Drug Repositioning and Vaccine Developments for the COVID-19 Pandemic." International Journal of Molecular Sciences, vol. 21, no. 24, 2020.
Won JH, Lee H. The Current Status of Drug Repositioning and Vaccine Developments for the COVID-19 Pandemic. Int J Mol Sci. 2020;21(24).
Won, J. H., & Lee, H. (2020). The Current Status of Drug Repositioning and Vaccine Developments for the COVID-19 Pandemic. International Journal of Molecular Sciences, 21(24). https://doi.org/10.3390/ijms21249775
Won JH, Lee H. The Current Status of Drug Repositioning and Vaccine Developments for the COVID-19 Pandemic. Int J Mol Sci. 2020 Dec 21;21(24) PubMed PMID: 33371468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Current Status of Drug Repositioning and Vaccine Developments for the COVID-19 Pandemic. AU - Won,Jung-Hyun, AU - Lee,Howard, Y1 - 2020/12/21/ PY - 2020/11/30/received PY - 2020/12/15/revised PY - 2020/12/18/accepted PY - 2020/12/29/entrez PY - 2020/12/30/pubmed PY - 2021/1/6/medline KW - COVID-19 KW - SARS-CoV-2 KW - drug repositioning KW - public health crisis KW - vaccine JF - International journal of molecular sciences JO - Int J Mol Sci VL - 21 IS - 24 N2 - Since the outbreak of coronavirus disease 2019 (COVID-19) was first identified, the world has vehemently worked to develop treatments and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at an unprecedented speed. Few of the repositioned drugs for COVID-19 have shown that they were efficacious and safe. In contrast, a couple of vaccines against SARS-CoV-2 will be ready for mass rollout early next year. Despite successful vaccine development for COVID-19, the world will face a whole new set of challenges including scale-up manufacturing, cold-chain logistics, long-term safety, and low vaccine acceptance. We highlighted the importance of knowledge sharing and collaboration to find innovative answers to these challenges and to prepare for newly emerging viruses. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/33371468/The_Current_Status_of_Drug_Repositioning_and_Vaccine_Developments_for_the_COVID_19_Pandemic_ DB - PRIME DP - Unbound Medicine ER -