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The potential mechanism of N-acetylcysteine in treating COVID-19.
Curr Pharm Biotechnol. 2020 Dec 28 [Online ahead of print]CP

Abstract

N-Acetylcysteine (NAC) has been proposed and used to treat coronavirus disease 2019 (COVID-19). By reviewing the existing pathological studies of COVID-19, it was found that abundant mucus secretion, formation of a hyaline membrane (supportive of acute respiratory distress syndrome), and interstitial fibrous exudation may be important characteristics of COVID-19 and may be pathological targets of drug therapy. In addition, multiple extrapulmonary organ injuries in COVID-19 may be associated with cytokine storm. NAC is an important antioxidant and anti-inflammatory drug. NAC has been demonstrated to have mucolytic effects in bronchitis, relieve respiratory failure in acute respiratory distress syndrome, and inhibit fibrous exudation in interstitial lung disease in clinical studies. These findings suggest that NAC may have a therapeutic effect on the pathological targets of COVID-19. Furthermore, NAC decreases TNF-α, IL-1β, IL-6, IL-8, IL-10, and IL-17 serum levels in patients with sepsis, severe burns, acute liver failure, or peritoneal dialysis and may also reduce cytokine storm in COVID-19. The antiviral effect of NAC on other respiratory viruses may also benefit COVID-19 patients. Summarizing the potential mechanisms of NAC in treating COVID-19 suggests that the role of NAC in COVID-19 treatment is worthy of further research.

Authors+Show Affiliations

Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022,. China.Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022,. China.The Second People's Hospital of Yichang, Yichang 443000,. China.Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022,. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33371832

Citation

Zhou, Nan, et al. "The Potential Mechanism of N-acetylcysteine in Treating COVID-19." Current Pharmaceutical Biotechnology, 2020.
Zhou N, Yang X, Huang A, et al. The potential mechanism of N-acetylcysteine in treating COVID-19. Curr Pharm Biotechnol. 2020.
Zhou, N., Yang, X., Huang, A., & Chen, Z. (2020). The potential mechanism of N-acetylcysteine in treating COVID-19. Current Pharmaceutical Biotechnology. https://doi.org/10.2174/1389201021999201228212043
Zhou N, et al. The Potential Mechanism of N-acetylcysteine in Treating COVID-19. Curr Pharm Biotechnol. 2020 Dec 28; PubMed PMID: 33371832.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The potential mechanism of N-acetylcysteine in treating COVID-19. AU - Zhou,Nan, AU - Yang,Xiaofan, AU - Huang,Aie, AU - Chen,Zhenbing, Y1 - 2020/12/28/ PY - 2020/08/10/received PY - 2020/11/12/revised PY - 2020/11/23/accepted PY - 2020/12/29/entrez PY - 2020/12/30/pubmed PY - 2020/12/30/medline KW - COVID-19 KW - N-acetylcysteine KW - SARS-CoV-2 KW - drug KW - mechanism KW - treatment JF - Current pharmaceutical biotechnology JO - Curr Pharm Biotechnol N2 - N-Acetylcysteine (NAC) has been proposed and used to treat coronavirus disease 2019 (COVID-19). By reviewing the existing pathological studies of COVID-19, it was found that abundant mucus secretion, formation of a hyaline membrane (supportive of acute respiratory distress syndrome), and interstitial fibrous exudation may be important characteristics of COVID-19 and may be pathological targets of drug therapy. In addition, multiple extrapulmonary organ injuries in COVID-19 may be associated with cytokine storm. NAC is an important antioxidant and anti-inflammatory drug. NAC has been demonstrated to have mucolytic effects in bronchitis, relieve respiratory failure in acute respiratory distress syndrome, and inhibit fibrous exudation in interstitial lung disease in clinical studies. These findings suggest that NAC may have a therapeutic effect on the pathological targets of COVID-19. Furthermore, NAC decreases TNF-α, IL-1β, IL-6, IL-8, IL-10, and IL-17 serum levels in patients with sepsis, severe burns, acute liver failure, or peritoneal dialysis and may also reduce cytokine storm in COVID-19. The antiviral effect of NAC on other respiratory viruses may also benefit COVID-19 patients. Summarizing the potential mechanisms of NAC in treating COVID-19 suggests that the role of NAC in COVID-19 treatment is worthy of further research. SN - 1873-4316 UR - https://www.unboundmedicine.com/medline/citation/33371832/The_potential_mechanism_of_N_acetylcysteine_in_treating_COVID_19_ L2 - https://www.eurekaselect.com/189560/article DB - PRIME DP - Unbound Medicine ER -
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