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Magnesium to prevent kidney disease-associated vascular calcification: crystal clear?
Nephrol Dial Transplant. 2022 02 25; 37(3):421-429.ND

Abstract

Vascular calcification is a prognostic marker for cardiovascular mortality in chronic kidney disease (CKD) patients. In these patients, magnesium balance is disturbed, mainly due to limited ultrafiltration of this mineral, changes in dietary intake and the use of diuretics. Observational studies in dialysis patients report that a higher blood magnesium concentration is associated with reduced risk to develop vascular calcification. Magnesium prevents osteogenic vascular smooth muscle cell transdifferentiation in in vitro and in vivo models. In addition, recent studies show that magnesium prevents calciprotein particle maturation, which may be the mechanism underlying the anti-calcification properties of magnesium. Magnesium is an essential protective factor in the calcification milieu, which helps to restore the mineral-buffering system that is overwhelmed by phosphate in CKD patients. The recognition that magnesium is a modifier of calciprotein particle maturation and mineralization of the extracellular matrix renders it a promising novel clinical tool to treat vascular calcification in CKD. Consequently, the optimal serum magnesium concentration for patients with CKD may be higher than in the general population.

Authors+Show Affiliations

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.Amsterdam Cardiovascular Sciences, Amsterdam UMC, Location VU University Medical Center, Amsterdam, The Netherlands.Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33374019

Citation

Ter Braake, Anique D., et al. "Magnesium to Prevent Kidney Disease-associated Vascular Calcification: Crystal Clear?" Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 37, no. 3, 2022, pp. 421-429.
Ter Braake AD, Vervloet MG, de Baaij JHF, et al. Magnesium to prevent kidney disease-associated vascular calcification: crystal clear? Nephrol Dial Transplant. 2022;37(3):421-429.
Ter Braake, A. D., Vervloet, M. G., de Baaij, J. H. F., & Hoenderop, J. G. J. (2022). Magnesium to prevent kidney disease-associated vascular calcification: crystal clear? Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 37(3), 421-429. https://doi.org/10.1093/ndt/gfaa222
Ter Braake AD, et al. Magnesium to Prevent Kidney Disease-associated Vascular Calcification: Crystal Clear. Nephrol Dial Transplant. 2022 02 25;37(3):421-429. PubMed PMID: 33374019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnesium to prevent kidney disease-associated vascular calcification: crystal clear? AU - Ter Braake,Anique D, AU - Vervloet,Marc G, AU - de Baaij,Jeroen H F, AU - Hoenderop,Joost G J, PY - 2020/03/07/received PY - 2020/12/30/pubmed PY - 2022/3/23/medline PY - 2020/12/29/entrez KW - calciprotein particle KW - chronic kidney disease KW - mineral homeostasis KW - phosphate KW - vascular smooth muscle cells SP - 421 EP - 429 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol Dial Transplant VL - 37 IS - 3 N2 - Vascular calcification is a prognostic marker for cardiovascular mortality in chronic kidney disease (CKD) patients. In these patients, magnesium balance is disturbed, mainly due to limited ultrafiltration of this mineral, changes in dietary intake and the use of diuretics. Observational studies in dialysis patients report that a higher blood magnesium concentration is associated with reduced risk to develop vascular calcification. Magnesium prevents osteogenic vascular smooth muscle cell transdifferentiation in in vitro and in vivo models. In addition, recent studies show that magnesium prevents calciprotein particle maturation, which may be the mechanism underlying the anti-calcification properties of magnesium. Magnesium is an essential protective factor in the calcification milieu, which helps to restore the mineral-buffering system that is overwhelmed by phosphate in CKD patients. The recognition that magnesium is a modifier of calciprotein particle maturation and mineralization of the extracellular matrix renders it a promising novel clinical tool to treat vascular calcification in CKD. Consequently, the optimal serum magnesium concentration for patients with CKD may be higher than in the general population. SN - 1460-2385 UR - https://www.unboundmedicine.com/medline/citation/33374019/Magnesium_to_prevent_kidney_disease_associated_vascular_calcification:_crystal_clear DB - PRIME DP - Unbound Medicine ER -