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Inactivation of Human Coronavirus by Titania Nanoparticle Coatings and UVC Radiation: Throwing Light on SARS-CoV-2.
Viruses. 2020 12 24; 13(1)V

Abstract

The newly identified pathogenic human coronavirus, SARS-CoV-2, led to an atypical pneumonia-like severe acute respiratory syndrome (SARS) outbreak called coronavirus disease 2019 (abbreviated as COVID-19). Currently, nearly 77 million cases have been confirmed worldwide with the highest numbers of COVID-19 cases in the United States. Individuals are getting vaccinated with recently approved vaccines, which are highly protective in suppressing COVID-19 symptoms but there will be a long way before the majority of individuals get vaccinated. In the meantime, safety precautions and effective disease control strategies appear to be vital for preventing the virus spread in public places. Due to the longevity of the virus on smooth surfaces, photocatalytic properties of "self-disinfecting/cleaning" surfaces appear to be a promising tool to help guide disinfection policies for controlling SARS-CoV-2 spread in high-traffic areas such as hospitals, grocery stores, airports, schools, and stadiums. Here, we explored the photocatalytic properties of nanosized TiO2 (TNPs) as induced by the UV radiation, towards virus deactivation. Our preliminary results using a close genetic relative of SAR-CoV-2, HCoV-NL63, showed the virucidal efficacy of photoactive TNPs deposited on glass coverslips, as examined by quantitative RT-qPCR and virus infectivity assays. Efforts to extrapolate the underlying concepts described in this study to SARS-CoV-2 are currently underway.

Authors+Show Affiliations

Department of Microbiology and Immunology, Reno School of Medicine, University of Nevada, 1664 N Virginia Street, Reno, NV 89557, USA.Department of Microbiology and Immunology, Reno School of Medicine, University of Nevada, 1664 N Virginia Street, Reno, NV 89557, USA.Chemical and Materials Engineering Department, University of Nevada, LME 309, MS 388, Reno, NV 89557, USA.Chemical and Materials Engineering Department, University of Nevada, LME 309, MS 388, Reno, NV 89557, USA. GenNEXT Materials and Technologies, LLC., Reno, NV 89511, USA.Department of Microbiology and Immunology, Reno School of Medicine, University of Nevada, 1664 N Virginia Street, Reno, NV 89557, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33374195

Citation

Khaiboullina, Svetlana, et al. "Inactivation of Human Coronavirus By Titania Nanoparticle Coatings and UVC Radiation: Throwing Light On SARS-CoV-2." Viruses, vol. 13, no. 1, 2020.
Khaiboullina S, Uppal T, Dhabarde N, et al. Inactivation of Human Coronavirus by Titania Nanoparticle Coatings and UVC Radiation: Throwing Light on SARS-CoV-2. Viruses. 2020;13(1).
Khaiboullina, S., Uppal, T., Dhabarde, N., Subramanian, V. R., & Verma, S. C. (2020). Inactivation of Human Coronavirus by Titania Nanoparticle Coatings and UVC Radiation: Throwing Light on SARS-CoV-2. Viruses, 13(1). https://doi.org/10.3390/v13010019
Khaiboullina S, et al. Inactivation of Human Coronavirus By Titania Nanoparticle Coatings and UVC Radiation: Throwing Light On SARS-CoV-2. Viruses. 2020 12 24;13(1) PubMed PMID: 33374195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inactivation of Human Coronavirus by Titania Nanoparticle Coatings and UVC Radiation: Throwing Light on SARS-CoV-2. AU - Khaiboullina,Svetlana, AU - Uppal,Timsy, AU - Dhabarde,Nikhil, AU - Subramanian,Vaidyanathan Ravi, AU - Verma,Subhash C, Y1 - 2020/12/24/ PY - 2020/08/24/received PY - 2020/12/17/revised PY - 2020/12/19/accepted PY - 2020/12/30/entrez PY - 2020/12/31/pubmed PY - 2021/1/20/medline KW - COVID-19 KW - SARS-CoV-2 KW - TNP coating KW - UV KW - virus inactivation JF - Viruses JO - Viruses VL - 13 IS - 1 N2 - The newly identified pathogenic human coronavirus, SARS-CoV-2, led to an atypical pneumonia-like severe acute respiratory syndrome (SARS) outbreak called coronavirus disease 2019 (abbreviated as COVID-19). Currently, nearly 77 million cases have been confirmed worldwide with the highest numbers of COVID-19 cases in the United States. Individuals are getting vaccinated with recently approved vaccines, which are highly protective in suppressing COVID-19 symptoms but there will be a long way before the majority of individuals get vaccinated. In the meantime, safety precautions and effective disease control strategies appear to be vital for preventing the virus spread in public places. Due to the longevity of the virus on smooth surfaces, photocatalytic properties of "self-disinfecting/cleaning" surfaces appear to be a promising tool to help guide disinfection policies for controlling SARS-CoV-2 spread in high-traffic areas such as hospitals, grocery stores, airports, schools, and stadiums. Here, we explored the photocatalytic properties of nanosized TiO2 (TNPs) as induced by the UV radiation, towards virus deactivation. Our preliminary results using a close genetic relative of SAR-CoV-2, HCoV-NL63, showed the virucidal efficacy of photoactive TNPs deposited on glass coverslips, as examined by quantitative RT-qPCR and virus infectivity assays. Efforts to extrapolate the underlying concepts described in this study to SARS-CoV-2 are currently underway. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/33374195/Inactivation_of_Human_Coronavirus_by_Titania_Nanoparticle_Coatings_and_UVC_Radiation:_Throwing_Light_on_SARS_CoV_2_ L2 - https://www.mdpi.com/resolver?pii=v13010019 DB - PRIME DP - Unbound Medicine ER -