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Is There Justification to Treat Neurodegenerative Disorders by Repurposing Drugs? The Case of Alzheimer's Disease, Lithium, and Autophagy.
Int J Mol Sci. 2020 Dec 27; 22(1)IJ

Abstract

Lithium is the prototype mood-stabilizer used for acute and long-term treatment of bipolar disorder. Cumulated translational research of lithium indicated the drug's neuroprotective characteristics and, thereby, has raised the option of repurposing it as a drug for neurodegenerative diseases. Lithium's neuroprotective properties rely on its modulation of homeostatic mechanisms such as inflammation, mitochondrial function, oxidative stress, autophagy, and apoptosis. This myriad of intracellular responses are, possibly, consequences of the drug's inhibition of the enzymes inositol-monophosphatase (IMPase) and glycogen-synthase-kinase (GSK)-3. Here we review lithium's neurobiological properties as evidenced by its neurotrophic and neuroprotective properties, as well as translational studies in cells in culture, in animal models of Alzheimer's disease (AD) and in patients, discussing the rationale for the drug's use in the treatment of AD.

Authors+Show Affiliations

Department of Clinical Biochemistry and Pharmacology and Psychiatry Research Unit, Faculty of Health Sciences, Ben-Gurion University of the Negev and Mental Health Center, Beer-Sheva 8461166, Israel.Department of Clinical Biochemistry and Pharmacology and Psychiatry Research Unit, Faculty of Health Sciences, Ben-Gurion University of the Negev and Mental Health Center, Beer-Sheva 8461166, Israel.Department of Clinical Biochemistry and Pharmacology and Psychiatry Research Unit, Faculty of Health Sciences, Ben-Gurion University of the Negev and Mental Health Center, Beer-Sheva 8461166, Israel.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33375448

Citation

Damri, Odeya, et al. "Is There Justification to Treat Neurodegenerative Disorders By Repurposing Drugs? the Case of Alzheimer's Disease, Lithium, and Autophagy." International Journal of Molecular Sciences, vol. 22, no. 1, 2020.
Damri O, Shemesh N, Agam G. Is There Justification to Treat Neurodegenerative Disorders by Repurposing Drugs? The Case of Alzheimer's Disease, Lithium, and Autophagy. Int J Mol Sci. 2020;22(1).
Damri, O., Shemesh, N., & Agam, G. (2020). Is There Justification to Treat Neurodegenerative Disorders by Repurposing Drugs? The Case of Alzheimer's Disease, Lithium, and Autophagy. International Journal of Molecular Sciences, 22(1). https://doi.org/10.3390/ijms22010189
Damri O, Shemesh N, Agam G. Is There Justification to Treat Neurodegenerative Disorders By Repurposing Drugs? the Case of Alzheimer's Disease, Lithium, and Autophagy. Int J Mol Sci. 2020 Dec 27;22(1) PubMed PMID: 33375448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is There Justification to Treat Neurodegenerative Disorders by Repurposing Drugs? The Case of Alzheimer's Disease, Lithium, and Autophagy. AU - Damri,Odeya, AU - Shemesh,Nofar, AU - Agam,Galila, Y1 - 2020/12/27/ PY - 2020/12/02/received PY - 2020/12/16/revised PY - 2020/12/23/accepted PY - 2020/12/30/entrez PY - 2020/12/31/pubmed PY - 2021/4/1/medline KW - Alzheimer’s disease KW - lithium KW - neurodegenerative disorders KW - repurposing drugs KW - treatment JF - International journal of molecular sciences JO - Int J Mol Sci VL - 22 IS - 1 N2 - Lithium is the prototype mood-stabilizer used for acute and long-term treatment of bipolar disorder. Cumulated translational research of lithium indicated the drug's neuroprotective characteristics and, thereby, has raised the option of repurposing it as a drug for neurodegenerative diseases. Lithium's neuroprotective properties rely on its modulation of homeostatic mechanisms such as inflammation, mitochondrial function, oxidative stress, autophagy, and apoptosis. This myriad of intracellular responses are, possibly, consequences of the drug's inhibition of the enzymes inositol-monophosphatase (IMPase) and glycogen-synthase-kinase (GSK)-3. Here we review lithium's neurobiological properties as evidenced by its neurotrophic and neuroprotective properties, as well as translational studies in cells in culture, in animal models of Alzheimer's disease (AD) and in patients, discussing the rationale for the drug's use in the treatment of AD. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/33375448/Is_There_Justification_to_Treat_Neurodegenerative_Disorders_by_Repurposing_Drugs_The_Case_of_Alzheimer's_Disease_Lithium_and_Autophagy_ DB - PRIME DP - Unbound Medicine ER -