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Dual-tDCS over the right prefrontal cortex does not modulate stop-signal task performance.
Exp Brain Res. 2021 Mar; 239(3):811-820.EB

Abstract

Stopping an already initiated action is crucial for human everyday behavior and empirical evidence points toward the prefrontal cortex playing a key role in response inhibition. Two regions that have been consistently implicated in response inhibition are the right inferior frontal gyrus (IFG) and the more superior region of the dorsolateral prefrontal cortex (DLPFC). The present study targets both regions with non-invasive brain stimulation to investigate their role in response inhibition. Thus dual-prefrontal transcranial direct current stimulation (tDCS) was applied to both IFG and DLPFC in a repeated measures design and compared to sham tDCS. Specifically, 9 cm2 electrodes were positioned over both IFG and DLPFC in all groups. The active stimulation groups received off-line, anodal or cathodal tDCS over the IFG and opposite polarity tDCS of the DLPFC, while the sham stimulation group received short stimulation at the start, middle and end of the supposed 20-min stimulation period. Before and after tDCS, subjects' inhibition capabilities were probed using the stop-signal task (SST). In a final sample of N = 45, participants were randomly split into three groups and received three different stimulation protocols. Results indicated that dual-frontal tDCS did not influence performance as compared to sham stimulation. This null result was confirmed using Bayesian analysis. This result is discussed against the background of the limitations of the present study as well as the potential theoretical implications.

Authors+Show Affiliations

University of Trier, Trier, Germany. maximilian.friehs@ucd.ie. School of Psychology, University College Dublin, Belfield, Dublin 4, Dublin, Ireland. maximilian.friehs@ucd.ie.University of Trier, Trier, Germany.University of Trier, Trier, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33392696

Citation

Friehs, Maximilian A., et al. "Dual-tDCS Over the Right Prefrontal Cortex Does Not Modulate Stop-signal Task Performance." Experimental Brain Research, vol. 239, no. 3, 2021, pp. 811-820.
Friehs MA, Brauner L, Frings C. Dual-tDCS over the right prefrontal cortex does not modulate stop-signal task performance. Exp Brain Res. 2021;239(3):811-820.
Friehs, M. A., Brauner, L., & Frings, C. (2021). Dual-tDCS over the right prefrontal cortex does not modulate stop-signal task performance. Experimental Brain Research, 239(3), 811-820. https://doi.org/10.1007/s00221-020-05995-5
Friehs MA, Brauner L, Frings C. Dual-tDCS Over the Right Prefrontal Cortex Does Not Modulate Stop-signal Task Performance. Exp Brain Res. 2021;239(3):811-820. PubMed PMID: 33392696.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dual-tDCS over the right prefrontal cortex does not modulate stop-signal task performance. AU - Friehs,Maximilian A, AU - Brauner,Lisa, AU - Frings,Christian, Y1 - 2021/01/04/ PY - 2020/09/16/received PY - 2020/11/19/accepted PY - 2021/1/5/pubmed PY - 2021/7/14/medline PY - 2021/1/4/entrez KW - Dorsolateral prefrontal cortex KW - Network compensation KW - Response inhibition KW - Stop-signal task KW - Transcranial direct current stimulation SP - 811 EP - 820 JF - Experimental brain research JO - Exp Brain Res VL - 239 IS - 3 N2 - Stopping an already initiated action is crucial for human everyday behavior and empirical evidence points toward the prefrontal cortex playing a key role in response inhibition. Two regions that have been consistently implicated in response inhibition are the right inferior frontal gyrus (IFG) and the more superior region of the dorsolateral prefrontal cortex (DLPFC). The present study targets both regions with non-invasive brain stimulation to investigate their role in response inhibition. Thus dual-prefrontal transcranial direct current stimulation (tDCS) was applied to both IFG and DLPFC in a repeated measures design and compared to sham tDCS. Specifically, 9 cm2 electrodes were positioned over both IFG and DLPFC in all groups. The active stimulation groups received off-line, anodal or cathodal tDCS over the IFG and opposite polarity tDCS of the DLPFC, while the sham stimulation group received short stimulation at the start, middle and end of the supposed 20-min stimulation period. Before and after tDCS, subjects' inhibition capabilities were probed using the stop-signal task (SST). In a final sample of N = 45, participants were randomly split into three groups and received three different stimulation protocols. Results indicated that dual-frontal tDCS did not influence performance as compared to sham stimulation. This null result was confirmed using Bayesian analysis. This result is discussed against the background of the limitations of the present study as well as the potential theoretical implications. SN - 1432-1106 UR - https://www.unboundmedicine.com/medline/citation/33392696/Dual_tDCS_over_the_right_prefrontal_cortex_does_not_modulate_stop_signal_task_performance_ L2 - https://dx.doi.org/10.1007/s00221-020-05995-5 DB - PRIME DP - Unbound Medicine ER -