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Trends in new prescription of gabapentinoids and of coprescription with opioids in the 4 nations of the UK, 1993-2017.
Br J Clin Pharmacol. 2021 08; 87(8):3349-3353.BJ

Abstract

We explored potential differences in time trends of gabapentinoid prescription and of opioid coprescription between 1993 and 2017 in the 4 UK nations using the Clinical Practice Research Datalink, a UK primary care database. There were distinct trends in annual rates of new gabapentin and pregabalin prescriptions in Northern Ireland. The rate of new gabapentin prescriptions rapidly increased after 2010 and exceeded that of the other nations by 2017 (rate of 836 [95% confidence interval: 787-887] per 100 000 person-years). Additionally, the rate of new pregabalin prescriptions was higher during the entire study period, reaching a peak of 1139 (95% confidence interval: 1088-1193) per 100 000 person-years in 2010, 5-fold higher than the other nations. Findings in Northern Ireland may be partly attributable to the high burden of anxiety disorders, an indication for pregabalin. Further exploration of reasons for discrepancies in gabapentinoid prescribing between UK nations is warranted.

Authors+Show Affiliations

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada. Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, UK.Department of Medical and Clinical Pharmacology, Centre of PharmacoVigilance and Pharmacoepidemiology, Toulouse University Hospital, Faculty of Medicine, Toulouse, France. INSERM, UMR 1027 Pharmacoepidemiology, Assessment of Drug Utilization and Drug Safety, CIC 1426 - University Paul Sabatier Toulouse, Toulouse, France.Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada. Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33393673

Citation

Rahman, Alvi, et al. "Trends in New Prescription of Gabapentinoids and of Coprescription With Opioids in the 4 Nations of the UK, 1993-2017." British Journal of Clinical Pharmacology, vol. 87, no. 8, 2021, pp. 3349-3353.
Rahman A, Kane J, Montastruc F, et al. Trends in new prescription of gabapentinoids and of coprescription with opioids in the 4 nations of the UK, 1993-2017. Br J Clin Pharmacol. 2021;87(8):3349-3353.
Rahman, A., Kane, J., Montastruc, F., & Renoux, C. (2021). Trends in new prescription of gabapentinoids and of coprescription with opioids in the 4 nations of the UK, 1993-2017. British Journal of Clinical Pharmacology, 87(8), 3349-3353. https://doi.org/10.1111/bcp.14727
Rahman A, et al. Trends in New Prescription of Gabapentinoids and of Coprescription With Opioids in the 4 Nations of the UK, 1993-2017. Br J Clin Pharmacol. 2021;87(8):3349-3353. PubMed PMID: 33393673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trends in new prescription of gabapentinoids and of coprescription with opioids in the 4 nations of the UK, 1993-2017. AU - Rahman,Alvi, AU - Kane,Joseph, AU - Montastruc,François, AU - Renoux,Christel, Y1 - 2021/01/19/ PY - 2020/11/24/revised PY - 2020/07/27/received PY - 2020/12/21/accepted PY - 2021/1/5/pubmed PY - 2021/10/28/medline PY - 2021/1/4/entrez KW - drug utilization KW - gabapentin KW - gabapentinoid KW - opioids KW - pregabalin SP - 3349 EP - 3353 JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 87 IS - 8 N2 - We explored potential differences in time trends of gabapentinoid prescription and of opioid coprescription between 1993 and 2017 in the 4 UK nations using the Clinical Practice Research Datalink, a UK primary care database. There were distinct trends in annual rates of new gabapentin and pregabalin prescriptions in Northern Ireland. The rate of new gabapentin prescriptions rapidly increased after 2010 and exceeded that of the other nations by 2017 (rate of 836 [95% confidence interval: 787-887] per 100 000 person-years). Additionally, the rate of new pregabalin prescriptions was higher during the entire study period, reaching a peak of 1139 (95% confidence interval: 1088-1193) per 100 000 person-years in 2010, 5-fold higher than the other nations. Findings in Northern Ireland may be partly attributable to the high burden of anxiety disorders, an indication for pregabalin. Further exploration of reasons for discrepancies in gabapentinoid prescribing between UK nations is warranted. SN - 1365-2125 UR - https://www.unboundmedicine.com/medline/citation/33393673/Trends_in_new_prescription_of_gabapentinoids_and_of_coprescription_with_opioids_in_the_4_nations_of_the_UK_1993_2017_ L2 - https://doi.org/10.1111/bcp.14727 DB - PRIME DP - Unbound Medicine ER -