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Altered neural responses to social fairness in bipolar disorder.
Neuroimage Clin. 2020; 28:102487.NC

Abstract

Bipolar Disorder (BD) has a debilitating impact on psychosocial functioning and social decision-making. Recent evidence using the Ultimatum Game (UG) has shown increased rejection of moderately unfair offers in BD, suggesting impaired processing of ambiguous social information related to fairness. The present study builds upon this finding to investigate the neural substrates of fairness processing in BD. During functional magnetic resonance imaging scanning, euthymic BD patients (n = 41) and matched healthy controls (HC; n = 41) accepted or rejected very unfair, moderately unfair, or fair offers in the UG. Acceptance rates of moderately unfair offers were significantly lower in BD patients. This aberrant behavior co-occurred with abnormal brain responses to moderately unfair offers. Compared to HC, BD patients exhibited hypoactivation of right anterior insula in response to moderately unfair offers suggesting impaired integration of affective and contextual information. BD patients also displayed stronger deactivation of posterior and middle insula in response to moderately unfair offers reflecting impaired processing of the contextual aspects of fairness. The level of impulsivity of BD patients positively correlated with the abnormal deactivation of posterior and middle insula. A separate analysis revealed increased activation of dorsal ACC and left ventrolateral PFC in response to rejected compared to accepted offers in BD patients. Taken together, our findings suggest impaired processing of ambiguous social information in euthymic BD patients which is associated with increased rejection of moderately unfair offers. This impairment may reflect a failure to integrate contextual information and may be related to increased trait impulsivity.

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Authors+Show Affiliations

Lois G
Department of Clinical Psychology and Neuropsychology, Institute of Psychology, Johannes Gutenberg-University Mainz, Germany; Department of Microeconomics and Public Economics, School of Business and Economics, Maastricht University, The Netherlands. Electronic address: i.lois@maastrichtuniversity.nl.
Schneider EE
Department of Clinical Psychology and Neuropsychology, Institute of Psychology, Johannes Gutenberg-University Mainz, Germany.
Kaurin A
Department of Clinical Psychology and Neuropsychology, Institute of Psychology, Johannes Gutenberg-University Mainz, Germany; German Resilience Center, Mainz, Germany; Department of Psychology, University of Pittsburgh, USA.
Wessa M
Department of Clinical Psychology and Neuropsychology, Institute of Psychology, Johannes Gutenberg-University Mainz, Germany; German Resilience Center, Mainz, Germany.

MeSH

Bipolar DisorderBrain MappingDecision MakingGames, ExperimentalHumansMagnetic Resonance ImagingSocial Behavior

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33395978

Citation

Lois, Giannis, et al. "Altered Neural Responses to Social Fairness in Bipolar Disorder." NeuroImage. Clinical, vol. 28, 2020, p. 102487.
Lois G, Schneider EE, Kaurin A, et al. Altered neural responses to social fairness in bipolar disorder. Neuroimage Clin. 2020;28:102487.
Lois, G., Schneider, E. E., Kaurin, A., & Wessa, M. (2020). Altered neural responses to social fairness in bipolar disorder. NeuroImage. Clinical, 28, 102487. https://doi.org/10.1016/j.nicl.2020.102487
Lois G, et al. Altered Neural Responses to Social Fairness in Bipolar Disorder. Neuroimage Clin. 2020;28:102487. PubMed PMID: 33395978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered neural responses to social fairness in bipolar disorder. AU - Lois,Giannis, AU - Schneider,Eva E, AU - Kaurin,Aleksandra, AU - Wessa,Michèle, Y1 - 2020/11/03/ PY - 2020/07/15/received PY - 2020/10/23/revised PY - 2020/10/25/accepted PY - 2021/1/5/entrez PY - 2021/1/6/pubmed PY - 2021/6/29/medline KW - Ambiguity KW - Bipolar disorder KW - Fairness KW - Social decision-making KW - Ultimatum game SP - 102487 EP - 102487 JF - NeuroImage. Clinical JO - Neuroimage Clin VL - 28 N2 - Bipolar Disorder (BD) has a debilitating impact on psychosocial functioning and social decision-making. Recent evidence using the Ultimatum Game (UG) has shown increased rejection of moderately unfair offers in BD, suggesting impaired processing of ambiguous social information related to fairness. The present study builds upon this finding to investigate the neural substrates of fairness processing in BD. During functional magnetic resonance imaging scanning, euthymic BD patients (n = 41) and matched healthy controls (HC; n = 41) accepted or rejected very unfair, moderately unfair, or fair offers in the UG. Acceptance rates of moderately unfair offers were significantly lower in BD patients. This aberrant behavior co-occurred with abnormal brain responses to moderately unfair offers. Compared to HC, BD patients exhibited hypoactivation of right anterior insula in response to moderately unfair offers suggesting impaired integration of affective and contextual information. BD patients also displayed stronger deactivation of posterior and middle insula in response to moderately unfair offers reflecting impaired processing of the contextual aspects of fairness. The level of impulsivity of BD patients positively correlated with the abnormal deactivation of posterior and middle insula. A separate analysis revealed increased activation of dorsal ACC and left ventrolateral PFC in response to rejected compared to accepted offers in BD patients. Taken together, our findings suggest impaired processing of ambiguous social information in euthymic BD patients which is associated with increased rejection of moderately unfair offers. This impairment may reflect a failure to integrate contextual information and may be related to increased trait impulsivity. SN - 2213-1582 UR - https://www.unboundmedicine.com/medline/citation/33395978/Altered_neural_responses_to_social_fairness_in_bipolar_disorder_ DB - PRIME DP - Unbound Medicine ER -