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Effects of soy intake on circulating levels of TNF-α and interleukin-6: a systematic review and meta-analysis of randomized controlled trials.
Eur J Nutr. 2021 Mar; 60(2):581-601.EJ

Abstract

PURPOSE

Pro-inflammatory mediators, including serum tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6), can be used as biomarkers to indicate or monitor disease. This study was designed to ascertain the effects of soy products on TNF-α and IL-6 levels.

METHODS

PubMed, EMBASE, Science Direct, Web of Science, Google Scholar and the Cochrane Central Register of Controlled Trials were searched to November 2019 for RCTs around the effects of soy-based products on TNF-α and IL-6. A random effects model was used to calculate overall effect size.

RESULTS

In total, 29 eligible publications were considered in the present systematic review, of which 25 were included in this meta-analysis. The overall effect of soy products on TNF-α and IL-6 levels failed to reach statistical significance (MD = - 0.07; 95% CI - 0.22-0.09; I2 50.9; MD = 0.03; 95% CI - 0.07-0.14; I2 42.1, respectively). According to a subgroup analysis, natural soy products led to a reduction in TNF-α concentration compared with processed soy products (MD = - 0.32; 95% CI - 0.45 to - 0.19; I2 0.0). Moreover, IL-6 reduction was stronger in participants who were affected by different diseases (MD = - 0.04; 95% CI - 0.07 to - 0.02; I2 0.0).

CONCLUSIONS

A review of RCTs published to November 2019 found that natural soy products are effective in lowering TNF-α levels. While the beneficial effects on reduction of IL-6 appeared stronger in individuals affected by different diseases, this finding cannot be generalized to all individuals affected by different diseases.

Authors+Show Affiliations

Nutrition Research Center, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Mahdieh_Khodarahmi@yahoo.com. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. Mahdieh_Khodarahmi@yahoo.com.Nutrition Research Center, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Department of Epidemiology and Biostatistics, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

33399974

Citation

Khodarahmi, Mahdieh, et al. "Effects of Soy Intake On Circulating Levels of TNF-α and Interleukin-6: a Systematic Review and Meta-analysis of Randomized Controlled Trials." European Journal of Nutrition, vol. 60, no. 2, 2021, pp. 581-601.
Khodarahmi M, Foroumandi E, Asghari Jafarabadi M. Effects of soy intake on circulating levels of TNF-α and interleukin-6: a systematic review and meta-analysis of randomized controlled trials. Eur J Nutr. 2021;60(2):581-601.
Khodarahmi, M., Foroumandi, E., & Asghari Jafarabadi, M. (2021). Effects of soy intake on circulating levels of TNF-α and interleukin-6: a systematic review and meta-analysis of randomized controlled trials. European Journal of Nutrition, 60(2), 581-601. https://doi.org/10.1007/s00394-020-02458-z
Khodarahmi M, Foroumandi E, Asghari Jafarabadi M. Effects of Soy Intake On Circulating Levels of TNF-α and Interleukin-6: a Systematic Review and Meta-analysis of Randomized Controlled Trials. Eur J Nutr. 2021;60(2):581-601. PubMed PMID: 33399974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of soy intake on circulating levels of TNF-α and interleukin-6: a systematic review and meta-analysis of randomized controlled trials. AU - Khodarahmi,Mahdieh, AU - Foroumandi,Elaheh, AU - Asghari Jafarabadi,Mohammad, Y1 - 2021/01/05/ PY - 2020/02/03/received PY - 2020/12/07/accepted PY - 2021/1/6/pubmed PY - 2021/6/1/medline PY - 2021/1/5/entrez KW - Inflammation KW - Interleukin-6 KW - Isoflavone KW - Meta-analysis KW - Soy KW - TNF-α SP - 581 EP - 601 JF - European journal of nutrition JO - Eur J Nutr VL - 60 IS - 2 N2 - PURPOSE: Pro-inflammatory mediators, including serum tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6), can be used as biomarkers to indicate or monitor disease. This study was designed to ascertain the effects of soy products on TNF-α and IL-6 levels. METHODS: PubMed, EMBASE, Science Direct, Web of Science, Google Scholar and the Cochrane Central Register of Controlled Trials were searched to November 2019 for RCTs around the effects of soy-based products on TNF-α and IL-6. A random effects model was used to calculate overall effect size. RESULTS: In total, 29 eligible publications were considered in the present systematic review, of which 25 were included in this meta-analysis. The overall effect of soy products on TNF-α and IL-6 levels failed to reach statistical significance (MD = - 0.07; 95% CI - 0.22-0.09; I2 50.9; MD = 0.03; 95% CI - 0.07-0.14; I2 42.1, respectively). According to a subgroup analysis, natural soy products led to a reduction in TNF-α concentration compared with processed soy products (MD = - 0.32; 95% CI - 0.45 to - 0.19; I2 0.0). Moreover, IL-6 reduction was stronger in participants who were affected by different diseases (MD = - 0.04; 95% CI - 0.07 to - 0.02; I2 0.0). CONCLUSIONS: A review of RCTs published to November 2019 found that natural soy products are effective in lowering TNF-α levels. While the beneficial effects on reduction of IL-6 appeared stronger in individuals affected by different diseases, this finding cannot be generalized to all individuals affected by different diseases. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/33399974/Effects_of_soy_intake_on_circulating_levels_of_TNF_α_and_interleukin_6:_a_systematic_review_and_meta_analysis_of_randomized_controlled_trials_ DB - PRIME DP - Unbound Medicine ER -