TY - JOUR T1 - Network Localization of Central Hypoventilation Syndrome in Lateral Medullary Infarction. AU - Prabhakar,Appaswamy, AU - Sivadasan,Ajith, AU - Shaikh,Atif, AU - Aaron,Sanjith, AU - Benjamin,Rohit, AU - Mani,Arun Mathai, AU - Mathew,Vivek, Y1 - 2020/08/17/ PY - 2020/06/10/received PY - 2020/07/16/revised PY - 2020/07/21/accepted PY - 2021/1/6/entrez PY - 2021/1/7/pubmed PY - 2021/6/4/medline KW - Lateral medullary infarction KW - Ondine's curse KW - central apnea KW - lesion network symptom mapping KW - pre‐Bötzinger complex SP - 875 EP - 881 JF - Journal of neuroimaging : official journal of the American Society of Neuroimaging JO - J Neuroimaging VL - 30 IS - 6 N2 - BACKGROUND AND PURPOSE: The brainstem plays a key role in the control of respiration. Strokes involving the lateral medulla can rarely produce a central hypoventilation syndrome (CHS) characterized by loss of automatic respiration called Ondine's curse. In this study, we investigated the neuroanatomical correlates of CHS in patients with lateral medullary infarction (LMI). METHODS: Cases of CHS following LMI were identified from searching our medical records and literature. Voxel-based lesion-symptom mapping and lesion network-symptom-mapping (LNSM) analysis was performed to identify the regions connected to the lesion sites based on normative functional connectome data. RESULTS: Sixteen patients with CHS and 32 controls were included. The ventro-lateral region of the rostral medulla showed a significant association with CHS. LNSM analysis showed connections of this region to the rostral ventro-lateral medulla and caudal pons. CONCLUSIONS: In patients with LMI, disruption of the respiratory control network, at the level of ventro-lateral region of the rostral medulla, could result in CHS. SN - 1552-6569 UR - https://www.unboundmedicine.com/medline/citation/33405315/Network_Localization_of_Central_Hypoventilation_Syndrome_in_Lateral_Medullary_Infarction_ DB - PRIME DP - Unbound Medicine ER -