TY - JOUR T1 - A chemo- and regioselective Pd(0)-catalyzed three-component spiroannulation. AU - Wu,Jiaoyu, AU - Bai,Lu, AU - Han,Lingbo, AU - Liu,Jingjing, AU - Luan,Xinjun, Y1 - 2021/01/07/ PY - 2021/1/8/pubmed PY - 2021/1/8/medline PY - 2021/1/7/entrez SP - 1117 EP - 1120 JF - Chemical communications (Cambridge, England) JO - Chem Commun (Camb) VL - 57 IS - 9 N2 - A chemo- and regioselective Pd(0)-catalyzed spiroannulation has been successfully developed. The key feature of this method is the use of readily available 1,2-dihaloarenes, alkynes and 2-naphthols for the rapid assembly of spirocarbocyclic molecules. Mechanistic studies revealed that this domino reaction proceeded through a cascade of oxidative addition to Pd(0), alkyne migratory insertion, and 2-naphthol-facilitated dearomatizing [4+1] spiroannulation. SN - 1364-548X UR - https://www.unboundmedicine.com/medline/citation/33410450/A_chemo__and_regioselective_Pd_0__catalyzed_three_component_spiroannulation_ DB - PRIME DP - Unbound Medicine ER -