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Chronic comorbidities and clinical outcomes in patients with and without COVID-19: a large population-based study using national administrative healthcare open data of Mexico.
Intern Emerg Med. 2021 09; 16(6):1507-1517.IE

Abstract

Coronavirus disease 2019 (COVID-19) was rapidly expanded worldwide within a short period. Its relationship with chronic comorbidities is still unclear. We aimed to determine the effects of chronic comorbidities on clinical outcomes of patients with and without COVID-19. This was an analysis of 65,535 patients with suspicion of viral respiratory disease (38,324 SARS-CoV-2 positive and 27,211 SARS-CoV-2 negative) from January 01 to May 12, 2020 using the national administrative healthcare open data of Mexico. SARS-CoV-2 infection was confirmed by reverse-transcriptase-polymerase-chain-reaction. General characteristics and chronic comorbidities were explored. Clinical outcomes of interest were hospital admission, pneumonia, intensive care unit admission, endotracheal intubation and mortality. Prevalence of chronic comorbidities was 49.4%. Multivariate logistic regression analysis showed that the effect of age, male sex, bronchial asthma, diabetes mellitus and chronic kidney disease on clinical outcomes was similar for both SARS-CoV-2 positive and negative patients. Adverse clinical outcomes were associated with the time from symptoms onset to medical contact, chronic obstructive pulmonary disease, hypertension and obesity in SARS-CoV-2 positive patients, but with cardiovascular disease in SARS-CoV-2 negative patients (p value < 0.01 for all comparisons). Chronic comorbidities are commonly found in patients with suspicion of viral respiratory disease. The knowledge of the impact of comorbidities on adverse clinical outcomes can better define those COVID-19 patients at higher risk. The different impact of the specific type of chronic comorbidity on clinical outcomes in patients with and without SARS-CoV-2 infection requires further researches. These findings need confirmation using other data sources.

Authors+Show Affiliations

Intensive Care Unit 8B, Hermanos Ameijeiras Hospital, 701 San Lázaro St., Havana Centre, 10300, Havana City, Cuba. fdmartos@infomed.sld.cu.Intensive Care Unit 8B, Hermanos Ameijeiras Hospital, 701 San Lázaro St., Havana Centre, 10300, Havana City, Cuba.Biomedical Research Division, Centre for Genetic Engineering and Biotechnology, 25th St., Playa, 10300, Havana City, Cuba.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33411264

Citation

Martos-Benítez, Frank Daniel, et al. "Chronic Comorbidities and Clinical Outcomes in Patients With and Without COVID-19: a Large Population-based Study Using National Administrative Healthcare Open Data of Mexico." Internal and Emergency Medicine, vol. 16, no. 6, 2021, pp. 1507-1517.
Martos-Benítez FD, Soler-Morejón CD, García-Del Barco D. Chronic comorbidities and clinical outcomes in patients with and without COVID-19: a large population-based study using national administrative healthcare open data of Mexico. Intern Emerg Med. 2021;16(6):1507-1517.
Martos-Benítez, F. D., Soler-Morejón, C. D., & García-Del Barco, D. (2021). Chronic comorbidities and clinical outcomes in patients with and without COVID-19: a large population-based study using national administrative healthcare open data of Mexico. Internal and Emergency Medicine, 16(6), 1507-1517. https://doi.org/10.1007/s11739-020-02597-5
Martos-Benítez FD, Soler-Morejón CD, García-Del Barco D. Chronic Comorbidities and Clinical Outcomes in Patients With and Without COVID-19: a Large Population-based Study Using National Administrative Healthcare Open Data of Mexico. Intern Emerg Med. 2021;16(6):1507-1517. PubMed PMID: 33411264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic comorbidities and clinical outcomes in patients with and without COVID-19: a large population-based study using national administrative healthcare open data of Mexico. AU - Martos-Benítez,Frank Daniel, AU - Soler-Morejón,Caridad Dios, AU - García-Del Barco,Diana, Y1 - 2021/01/07/ PY - 2020/08/19/received PY - 2020/12/02/accepted PY - 2021/1/8/pubmed PY - 2021/8/25/medline PY - 2021/1/7/entrez KW - COVID-19 KW - Diabetes mellitus KW - Hypertension KW - Mortality KW - Obesity KW - SARS-CoV-2 SP - 1507 EP - 1517 JF - Internal and emergency medicine JO - Intern Emerg Med VL - 16 IS - 6 N2 - Coronavirus disease 2019 (COVID-19) was rapidly expanded worldwide within a short period. Its relationship with chronic comorbidities is still unclear. We aimed to determine the effects of chronic comorbidities on clinical outcomes of patients with and without COVID-19. This was an analysis of 65,535 patients with suspicion of viral respiratory disease (38,324 SARS-CoV-2 positive and 27,211 SARS-CoV-2 negative) from January 01 to May 12, 2020 using the national administrative healthcare open data of Mexico. SARS-CoV-2 infection was confirmed by reverse-transcriptase-polymerase-chain-reaction. General characteristics and chronic comorbidities were explored. Clinical outcomes of interest were hospital admission, pneumonia, intensive care unit admission, endotracheal intubation and mortality. Prevalence of chronic comorbidities was 49.4%. Multivariate logistic regression analysis showed that the effect of age, male sex, bronchial asthma, diabetes mellitus and chronic kidney disease on clinical outcomes was similar for both SARS-CoV-2 positive and negative patients. Adverse clinical outcomes were associated with the time from symptoms onset to medical contact, chronic obstructive pulmonary disease, hypertension and obesity in SARS-CoV-2 positive patients, but with cardiovascular disease in SARS-CoV-2 negative patients (p value < 0.01 for all comparisons). Chronic comorbidities are commonly found in patients with suspicion of viral respiratory disease. The knowledge of the impact of comorbidities on adverse clinical outcomes can better define those COVID-19 patients at higher risk. The different impact of the specific type of chronic comorbidity on clinical outcomes in patients with and without SARS-CoV-2 infection requires further researches. These findings need confirmation using other data sources. SN - 1970-9366 UR - https://www.unboundmedicine.com/medline/citation/33411264/Chronic_comorbidities_and_clinical_outcomes_in_patients_with_and_without_COVID_19:_a_large_population_based_study_using_national_administrative_healthcare_open_data_of_Mexico_ L2 - https://dx.doi.org/10.1007/s11739-020-02597-5 DB - PRIME DP - Unbound Medicine ER -