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Neurological features and outcome in COVID-19: dementia can predict severe disease.
J Neurovirol. 2021 02; 27(1):86-93.JN

Abstract

The COVID-19 pandemic has infected more than 22 million people worldwide. Although much has been learned about COVID-19, we do not know much about its neurological features and their outcome. This observational study was conducted on the patients of Imam Hossein Hospital, and 361 adult patients (214 males) with confirmed diagnosis of COVID-19 from March 5, 2020 to April 3, 2020, were enrolled. Data was gathered on age, sex, comorbidities, initial symptoms, symptoms during the disease course, neurological symptoms, and outcome. The mean age of the patients was 61.90 ± 16.76 years. The most common initial symptoms were cough, fever, and dyspnea. In 21 patients (5.8%), the initial symptom was neurological. History of dementia was associated with severe COVID-19 disease (odds ratio = 1.28). During the course of the disease, 186 patients (51.52%) had at least one neurological symptom, the most common being headache (109 [30.2%]), followed by anosmia/ageusia (69, [19.1%]), and dizziness (54, [15%]). Also, 31 patients had neurological complications (8.58%). Anosmia, ageusia, dizziness, and headache were associated with favorable outcome (P < 0.001), while altered mental status and hemiparesis were associated with poor outcome. The mortality rate of patients who had neurological complications was more than twice than that of patients without neurological complication (P = 0.008). Almost half of the patients experienced at least one neurological symptom, which may be the initial presentation of COVID-19. Dementia appears to be associated with severe COVID-19. Mortality was higher in patients with neurological complications, and these patients needed more intensive care.

Authors+Show Affiliations

Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Headache and Facial Pain Clinic, Kaizen Brain Center, San Diego, USA. Department of Neurology, University of California, San Diego, USA.Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Infectious Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Infectious Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Infectious Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. drbehnam_safarpour@yahoo.com. Imam Hossein Medical and Educational Center , Madani Street, Tehran, Iran. drbehnam_safarpour@yahoo.com.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

33417193

Citation

Ghaffari, Mehran, et al. "Neurological Features and Outcome in COVID-19: Dementia Can Predict Severe Disease." Journal of Neurovirology, vol. 27, no. 1, 2021, pp. 86-93.
Ghaffari M, Ansari H, Beladimoghadam N, et al. Neurological features and outcome in COVID-19: dementia can predict severe disease. J Neurovirol. 2021;27(1):86-93.
Ghaffari, M., Ansari, H., Beladimoghadam, N., Aghamiri, S. H., Haghighi, M., Nabavi, M., Mansouri, B., Mehrpour, M., Assarzadegan, F., Hesami, O., Sedaghat, M., Farahbakhsh, M., & Lima, B. S. (2021). Neurological features and outcome in COVID-19: dementia can predict severe disease. Journal of Neurovirology, 27(1), 86-93. https://doi.org/10.1007/s13365-020-00918-0
Ghaffari M, et al. Neurological Features and Outcome in COVID-19: Dementia Can Predict Severe Disease. J Neurovirol. 2021;27(1):86-93. PubMed PMID: 33417193.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurological features and outcome in COVID-19: dementia can predict severe disease. AU - Ghaffari,Mehran, AU - Ansari,Hossein, AU - Beladimoghadam,Nahid, AU - Aghamiri,Seyed Hossein, AU - Haghighi,Mehrdad, AU - Nabavi,Mahmoud, AU - Mansouri,Behnam, AU - Mehrpour,Masoud, AU - Assarzadegan,Farhad, AU - Hesami,Omid, AU - Sedaghat,Meghdad, AU - Farahbakhsh,Mohammad, AU - Lima,Behnam Safarpour, Y1 - 2021/01/08/ PY - 2020/08/24/received PY - 2020/10/01/accepted PY - 2020/09/21/revised PY - 2021/1/9/pubmed PY - 2021/3/13/medline PY - 2021/1/8/entrez KW - COVID-19 KW - Dementia KW - Mortality KW - Nervous system KW - Neurology KW - SARS-CoV-2 SP - 86 EP - 93 JF - Journal of neurovirology JO - J Neurovirol VL - 27 IS - 1 N2 - The COVID-19 pandemic has infected more than 22 million people worldwide. Although much has been learned about COVID-19, we do not know much about its neurological features and their outcome. This observational study was conducted on the patients of Imam Hossein Hospital, and 361 adult patients (214 males) with confirmed diagnosis of COVID-19 from March 5, 2020 to April 3, 2020, were enrolled. Data was gathered on age, sex, comorbidities, initial symptoms, symptoms during the disease course, neurological symptoms, and outcome. The mean age of the patients was 61.90 ± 16.76 years. The most common initial symptoms were cough, fever, and dyspnea. In 21 patients (5.8%), the initial symptom was neurological. History of dementia was associated with severe COVID-19 disease (odds ratio = 1.28). During the course of the disease, 186 patients (51.52%) had at least one neurological symptom, the most common being headache (109 [30.2%]), followed by anosmia/ageusia (69, [19.1%]), and dizziness (54, [15%]). Also, 31 patients had neurological complications (8.58%). Anosmia, ageusia, dizziness, and headache were associated with favorable outcome (P < 0.001), while altered mental status and hemiparesis were associated with poor outcome. The mortality rate of patients who had neurological complications was more than twice than that of patients without neurological complication (P = 0.008). Almost half of the patients experienced at least one neurological symptom, which may be the initial presentation of COVID-19. Dementia appears to be associated with severe COVID-19. Mortality was higher in patients with neurological complications, and these patients needed more intensive care. SN - 1538-2443 UR - https://www.unboundmedicine.com/medline/citation/33417193/Neurological_features_and_outcome_in_COVID_19:_dementia_can_predict_severe_disease_ L2 - https://dx.doi.org/10.1007/s13365-020-00918-0 DB - PRIME DP - Unbound Medicine ER -