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Neurological manifestations of coronavirus disease 2019: exploring past to understand present.
Neurol Sci. 2021 Mar; 42(3):773-785.NS

Abstract

SARS-CoV-2 infection, resulting in Coronavirus disease 2019 (COVID-19), has significantly affected the entire world. It was labelled a pandemic by World Health Organization. Although it commonly produces respiratory symptoms, neurological features have been described. Neurological manifestations may vary from non-specific symptoms such as headache, dizziness, myalgia and/or fatigue, olfactory or taste dysfunction to specific syndromes including meningitis, stroke, acute transverse myelitis and Guillain-Barre syndrome. This review describes potential pathogenetic mechanisms and neurological manifestations of COVID-19 along with its management. Considering structural and pathogenetic similarity of SARS-CoV-2 with SARS-CoV and MERS viruses, we compared their neurological manifestations and mentioned few features expected in COVID-19 in future. Interestingly, many COVID-19 cases may present with pure neurological manifestations at onset with non-neurological features manifesting few days later and we propose the term "Neuro-COVID syndrome" for such cases. Awareness of neurological manifestations may facilitate its management and improve outcome in such patients.

Authors+Show Affiliations

Department of Neurology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.Department of Neurology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.Department of Neurology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India. drnirajkumarsingh@gmail.com.Department of Neurology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.Department of Neurology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33428055

Citation

Desai, Ishita, et al. "Neurological Manifestations of Coronavirus Disease 2019: Exploring Past to Understand Present." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 42, no. 3, 2021, pp. 773-785.
Desai I, Manchanda R, Kumar N, et al. Neurological manifestations of coronavirus disease 2019: exploring past to understand present. Neurol Sci. 2021;42(3):773-785.
Desai, I., Manchanda, R., Kumar, N., Tiwari, A., & Kumar, M. (2021). Neurological manifestations of coronavirus disease 2019: exploring past to understand present. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 42(3), 773-785. https://doi.org/10.1007/s10072-020-04964-8
Desai I, et al. Neurological Manifestations of Coronavirus Disease 2019: Exploring Past to Understand Present. Neurol Sci. 2021;42(3):773-785. PubMed PMID: 33428055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurological manifestations of coronavirus disease 2019: exploring past to understand present. AU - Desai,Ishita, AU - Manchanda,Rajat, AU - Kumar,Niraj, AU - Tiwari,Ashutosh, AU - Kumar,Mritunjai, Y1 - 2021/01/11/ PY - 2020/10/13/received PY - 2020/12/04/accepted PY - 2021/1/12/pubmed PY - 2021/2/12/medline PY - 2021/1/11/entrez KW - COVID-19 KW - Coronavirus KW - Neuro-COVID syndrome KW - SARS-CoV-2 KW - neuroinvasion KW - neurological manifestations SP - 773 EP - 785 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 42 IS - 3 N2 - SARS-CoV-2 infection, resulting in Coronavirus disease 2019 (COVID-19), has significantly affected the entire world. It was labelled a pandemic by World Health Organization. Although it commonly produces respiratory symptoms, neurological features have been described. Neurological manifestations may vary from non-specific symptoms such as headache, dizziness, myalgia and/or fatigue, olfactory or taste dysfunction to specific syndromes including meningitis, stroke, acute transverse myelitis and Guillain-Barre syndrome. This review describes potential pathogenetic mechanisms and neurological manifestations of COVID-19 along with its management. Considering structural and pathogenetic similarity of SARS-CoV-2 with SARS-CoV and MERS viruses, we compared their neurological manifestations and mentioned few features expected in COVID-19 in future. Interestingly, many COVID-19 cases may present with pure neurological manifestations at onset with non-neurological features manifesting few days later and we propose the term "Neuro-COVID syndrome" for such cases. Awareness of neurological manifestations may facilitate its management and improve outcome in such patients. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/33428055/Neurological_manifestations_of_coronavirus_disease_2019:_exploring_past_to_understand_present_ L2 - https://link.springer.com/10.1007/s10072-020-04964-8 DB - PRIME DP - Unbound Medicine ER -